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Showing 1 to 20 of 34 for “"nitrosative stress"”.

  1. Oxidative stress and nitrosative stress, their interaction and implications for bioprocessing

    Kretzers, IvoUniversity of Strathclyde2014

    … of physiological studies to study oxidative and nitrosative stress and online monitoring of fungal biomass growth in submerged batch cultures of the filamentous fungus Aspergillus niger B1-D, modified to secrete lysozyme. The results of the undertaken studies described here show that increasing …

    strathclyde Repository record

  2. DEVELOPMENT OF MICROCHIP ELECTROPHORESIS BASED METHODS TO PROFILE CELLULAR NITROSATIVE STRESS

    Gunasekara, Dulan B.University of Kansas2014

    … To help maintain cellular redox homeostasis in nitrosative and oxidative stress, antioxidant molecules are present in the cells. However, excessive nitrosative stress can alter the balance between antioxidants and prooxidants and therefore it plays an important role in cancer, cardiovascular and …

    ku Repository record

  3. Studies of dietary nitrate induced nitrosative stress in the upper gastrointestinal tract

    Paterson, StuartUniversity of Glasgow2008

    … phase in the absence of ascorbic acid generated nitrosative stress within the aqueous phase. The addition of physiological concentrations of ascorbic acid to the aqueous phase prevents nitrosative stress within the aqueous phase but in so doing generates nitrosative stress within the lipid phase. …

    glasgow Repository record

  4. Studies of in situ nitrosative stress following nitrate ingestion in the human upper gastrointestinal tract

    Winter, Jack WestwoodUniversity of Glasgow2008

    … meets gastric acid. Nitric oxide generates N-nitrosative stress on reacting with oxygen at neutral pH. We aimed to ascertain if luminal nitric oxide exerts nitrosative stress in the upper GI tract, and to assess the influence of acid reflux. We utilised a specialised silicone tube as an …

    glasgow Repository record

  5. Cytochrome c peroxidase : its role in nitrosative stress and purification as a GST-fusion protein

    Bakas, Iolie C1999

    … roles is to protect the cell against oxidative stress by reducing mitochondrial H 2 O 2 to H 2 O. Titration of CCP with peroxynitrite [ONOO(H)] formed a species with an absorption spectrum identical to compound I/II at a ONOO(H)/CCP ratio of 1.65 ± 0.10. Titration of the CCP species formed with …

    concordia Repository record

  6. Regulation of flagellin glycosylation genes in Campylobacter jejuni: influence of NssR, the nitrosative stress response regulator.

    Blackwell, GemmaUniversity of Birmingham2010

    … remain unclear. The response to nitric oxide stress in C. jejuni is regulated by NssR, which also regulates a small number of genes in the flagellin glycosylation locus; an nssR mutant has defective motility. This work aims to elucidate the mechanisms by which NssR regulates these genes and …

    birmingham Repository record

  7. <i>Plasmodium</i>-Induced Nitrosative Stress in <i>Anopheles stephensi</i>: The Cost of Host Defense

    Peterson, Tina Marie LoaneVirginia Tech2005

    … nitrogen intermediates (RNIs) that may impose a nitrosative stress. These RNIs are proposed to be responsible for the AsNOS-dependent inhibition of <i>Plasmodium</i> development. In my studies, I identified several RNIs that are induced in the blood-filled midgut in response to <i>Plasmodium</i> …

    vt Repository record

  8. Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury

    Aimalohi EsechieThe University of Texas Medical Branch2008

    … counteract pulmonary dysfunction associated with nitrosative stress generated after B + S inhalation injury in an ovine and murine model of ALI. \r\nIn our time course experiment, sheep were sacrificed at 4, 8, 12, 18 and 24 hours post B + S injury. From 4 through 24 hours, there was a progressive …

    utmb Repository record

  9. THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES

    Alfarawati, Obada 1993-The University of Texas Medical Branch at Galveston2025

    … assays to characterize oxidative stress levels via measurement of glutathione peroxidase activity, nitrosative stress levels by measuring nitrite concentrations, and lipid peroxidation damage by measuring malondialdehyde in bronchoalveolar lavage fluid. The results showed that …

    utmb Repository record

  10. The regulation of genes of unknown function implicated in nitrosative stress tolerance in Escherichia coli K-12

    Squire, Derrick J.P.University of Birmingham2009

    … \(yeaR-yoaG\) and another operon implicated in nitrosative stress management, \(hcp-hcr\), were unknown. Strains carrying a chromosomal \(yeaR-yoaG\) deletion were not more sensitive to nitric oxide or hydroxylamine compared with the parental strain, suggesting that the products of this operon …

    birmingham Repository record

  11. Characterization of the MexT Regulator of the mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa

    Fetar, Hossam2011

    … As nitration is a well-known result of nitrosative stress, a role for xenB (and the co-regulated mexEF-oprN and PA2813-2812-2811) in a nitrosative stress response was hypothesized and tested. Using S-nitrosoglutathione (GSNO) as a source of nitrosative stress, expression of mexEF-oprN, …

    queens Repository record

  12. HcpR of Porphyromonas gingivalis utilizes heme to bind NO

    Belvin, Benjamin2019

    … mechanisms allowing for protection against such stress remain poorly understand. HcpR is an FNR-CRP family regulator that has been implicated in regulation of the nitrosative stress response. In this study we characterize the biochemical properties of HcpR. It is a homo-dimer that is composed of …

    vcu Repository record

  13. Oxidative stress markers in neurological diseases and disorders: electrochemical detection of hydrogen peroxide and nitric oxide

    O'Riordan, SaidhbheNational University of Ireland Maynooth2013

    … is the detection of NO and H2O2 as oxidative/nitrosative stress markers in neurological disease and dysfunction. As such the role of oxidative/nitrosative stress in Parkinson’s disease (PD) and autism spectrum disorders (ASDs) is investigated in this thesis. The novel detection of NO in a …

    maynooth Repository record

  14. Investigation of the potential bacterial proteasome homologue Anbu

    Suknaic, Stephen R.2014

    … wild type and mutants. Cultures were grown under stress conditions including the oxidative stress of diamide and the nitrosative stress of S-nitrosoglutathione. Growth rates were monitored in an attempt to detect a phenotypic difference between the wild type and the mutants lacking Anbu, HslV, and …

    iupui Repository record

  15. Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis

    Williams, Monique JDivision of Medical Microbiology2007

    … protecting M tuberculosis against oxidative and nitrosative stress. To date, no ergothioneine-deficient mutants have been identified and the role of ergothioneine in mycobacteria remains unknown. The work in this thesis was performed with the aim of better understanding the function of …

    cape-town Repository record

  16. Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)

    Lim, JunghwaVirginia Tech2004

    … defense genes that may defend parasites against nitrosative stress caused by AsNOS induction, expression of several antioxidant defense genes known to function in nitrosative stress defense in a variety of organisms were examined during sporogonic development. Notably, increased expression levels …

    vt Repository record

  17. Analysis of resistance nodulation division efflux pumps in Acinetobacter baumannii

    Fernando, Dinesh MalindaUniversity of Ontario Institute of Technology2015

    … peptide formation and not DNA synthesis error or nitrosative stress. In addition strain specific differences likely also account for differences in phenotypic observations since nitrosative stress has improved tolerance and induced adeFGH expression in ATCC19606 and AB031. Finally analysis of …

    uoit Repository record

  18. Understanding the physiological role of cofactor F 420 in mycobacterium

    RAO MARTIN VIJAYAKUMAR2009

    … were very highly susceptible to death by nitrosative stress and unable to rejuvenate as robustly as wild type BCG after exposure to hypoxic conditions. Due to time constraints, we could not proceed with molecular anaylsis of the mechanisms underlying our findings. Nevertheless, this opens …

    nus Repository record

  19. Interdomain Repression in the Enhancer Binding Protein NorR

    Bush, MatthewUniversity of East Anglia2011

    … of the norVW genes under conditions of nitrosative stress. Binding of NorR to three conserved enhancer sites upstream of the norVW promoter is essential for transcriptional activation and promotes the formation of a stable higher-order nucleoprotein complex. NorR falls into a class of …

    east-anglia Repository record

  20. The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation

    Chuang, Dennis Yi-Lun, 1985-University of Missouri--Columbia2016

    Oxidative and nitrosative stress is known to play an important role in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease, Parkinson's disease, ischemic[slash]hemorrhagic stroke, and traumatic brain injury. Microglia are the primary innate immune cells in the central …

    missouri Repository record

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