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Showing 1 to 10 of 10 for “"nitric oxide reductase"”.
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Characterization of the quinol nitric oxide reductase from Peresephonella marina
qNOR is a nitric oxide reductase in the heme-copper oxidoreductase superfamily that catalyzes the two electron reduction of NO to N2O using electrons derived from quinol. In this study, we heterologously expressed and characterized the qNOR from the thermophilic, denitrifying bacteria Persephonella …
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Engineering Myoglobin Into Both a Structural and Functional Model of Nitric Oxide Reductase
To date, FeBMb is the first protein model of the FeB site of NOR and provides the first evidence, from an NOR model, that the identity of the metal in analogous non-heme metal binding sites of HCO (i.e., CuB) and NOR (i.e., FeB) can tune NO activity. In summary, FeBMb is both a structural and …
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Studies on the cytochrome bd-type oxygen reductase superfamily and the discovery of a novel nitric oxide reductase
… respiration on the planet– the bd-type oxygen reductase superfamily and the heme-copper oxidoreductase superfamily. The bd-type oxygen reductases are present in bacteria and archaea and catalyze the 4-electron reduction of oxygen to water. Electrons from membrane bound quinols first reduce a …
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Characterizing a structural and functional model of nitric oxide reductase performing NO and O2 reduction in engineered myoglobin
Nitric oxide reductase (NOR) is a membrane-bound metalloenzyme in the denitrification pathway of many bacteria. NORs are structurally homologous to subunit I of HCOs (heme-copper oxidases); however, the copper site (CuB) in HCOs is replaced with a non-heme iron site (FeB) in NOR, and each metal …
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The Heme -Copper Oxidoreductase Superfamily: Genomics and Structural Analyses
… the sequence diversity of the heme-copper oxidoreductase superfamily by analyzing over 1100 microbial genomes (Bacteria and Archaea) and nine microbial environmental metagenomic datasets. Over 2000 new putative members were found which we classify into eight oxygen reductase families (A-, B-, …
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The electron transport chains of Neisseria meningitidis
… with the oxidation of a b-haem containing nitric oxide reductase. Nitrite inhibits the oxidation of cytochromes by oxygen in a nitrite reductase-independent manner, indicating that nitrite may inhibit oxidase activity directly, as well as via the intermediate of denitrification, nitric …
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Optimizing electrogenic activity from photosynthetic bacteria in bioelectrochemical systems
… deletion of a bi-directional hydrogenase – HoxH, nitric oxide reductase – NorB, cytochrome-c oxidase – COX, bd-quinol oxidase – cyd, and the respiratory terminal oxidase – ARTO, roughly doubled light driven electron flux to EET. Deletion of nitrate reductase – NarB, and nitrite reductase – NirA, …
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The evolution and diversity of noncanonical microbial nitrogen metabolisms
… I report a novel cytochrome-type nitrite reductase (nirS) structure within members of Phylum Chloroflexi, which includes a cytochrome superfamily domain in addition to functional domains conserved in Proteobacterial nirS. Phylogenetic domain mapping reveals that this gene resulted from a …
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Microscopic description of gas permeation and delivery pathways in biological macromolecules
… of inorganic molecules such as dioxygen (O2), nitric oxide (NO), carbon dioxide (CO2) and ammonia (NH3). These chemical species often act as substrates of enzymes and/or as ligands modulating biochemical cascades, so elucidating their delivery and transport is imminent towards understanding …
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Understanding structure-function relations in heme-copper oxidase using myoglobin-based enzyme models
Heme-copper oxygen reductases (HCOs) are respiratory enzymes that utilize a heme-copper center to perform the four-electron reduction of oxygen to water. The HCOs share significant structural and sequence homology to another class of metalloenzyme, nitric oxide reductase (NOR), that in turn, …