Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"nipah"”.
-
The spread of Nipah and chikungunya viruses: implications for control
… to cause a substantial burden on public health. Nipah and chikungunya have been identified as two emerging viruses that pose a significant threat with pandemic potential. This has led to considerable investment in the development of vaccines against the two pathogens, especially by the Coalition …
-
Nipah: The history, and future, of one of the world’s most lethal viruses
The Nipah virus kills around three quarters of people who contract it, making it one of the most lethal viruses known to infect humans. The virus first emerged in 1998, when hundreds of pig farmers in Malaysia fell ill with fevers and encephalitis, or brain inflammation. Nipah has caused smaller …
-
Elucidating Mechanisms of Immunity to Nipah Virus Infection through Generation of Attenuated Viruses and a Single-Cycle Vectored Vaccine
Nipah virus (NiV) is an emerging paramyxovirus that has caused outbreaks with high case-fatality rates in South and Southeast Asia. Mechanisms of NiV virulence are poorly understood, and there is no licensed vaccine nor treatment. Accessory proteins produced from the NiV P gene through …
-
Exploring Nipah virus strain differences through use of recombinant and chimeric viruses as well as utilization of a novel 3D human lung model
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis and respiratory illness in humans. There are two variants of NiV - NiV Malaysia (NiVM) and NiV Bangladesh (NiVB). Despite high sequence homology between the strains, there are several key differences in …
-
Characterization of soft soil using multi-channel analysis of surface waves (MASW) and electrical resistivity method (ERM)
… data. The research was conducted at Parit Nipah and RECESS UTHM. The Vs obtained for peat and soft clay at Parit Nipah was in the range of 29.7 to 34.9 m/s and 36.8 to 76.9 m/s respectively. While, the soft clay Vs obtained at RECESS was in the range of 64.4 to 124.0 m/s. The lower Vs …
-
A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
… Comparison of the IFN antagonist V protein from Nipah virus, a member of the paramyxovirus family showed sequence similarity to the STAT1-binding region of 018. We showed, like 018, Nipah V protein blocks STAT1 association with the active IFN receptor. Furthermore, we provide mechanistic detail …
-
Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… We also engineered NDV M based particles with nipah virus surface glycorporteins to target ephrin B receptors. NDV based nipah Virus BNPs (NiV-ndBNP) were morphologically similar to authentic NiV virions. NiV glycoproteins were incorporated into the NDV M based particles, despite poor sequence …
-
Comparative Respiratory Tract Pathology of Emerging Viral Infections
… our studies on two recently emerged viruses, Nipah virus and the Middle East respiratory syndrome coronavirus (MERS-CoV), which have caused significant respiratory disease and death in humans.
-
Learning from pre-pandemic data to forecast viral antibody escape
… with pandemic potential such as Lassa and Nipah. We provide continually updated escape scores for all current strains of SARS-CoV-2 and predict likely additional mutations to forecast emerging strains as a tool for ongoing vaccine development (evescape.org).
-
Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
… manage to host highly pathogenic viruses such a Nipah and Marburg without showing clinical symptoms remains unclear. One of the earliest defenses vertebrates use to control viral infections is the interferon response. Upon viral infection, cells produce interferon which inhibits viral infection …
-
VIRUS-HOST INTERACTIONS AND THE IMPACT ON HOST CELLULAR MECHANISMS
… family that includes the emergent and deadly Nipah (NiV) and Hendra (HeV) viruses. These viruses possess substantial pandemic potential and exhibit an expansive host range, a characteristic underpinned by their conserved ephrin receptors. Being a highly virulent zoonotic pathogen, NiV has …
-
The performance of polyurethane grout to stabilise hemic peat
… material with very short curing time. The Parit Nipah hemic peat has high natural moisture content (> 500%) with high initial void ratio (6.72-10.11) and compression index, cc between 3.17 to 4.57. Optimum mixing ratio for PU of 1:2 (polyol:isocyanate) was established to be used for PU grouting …
-
Learning from pre-pandemic data to design and test future-proof therapeutics
… with pandemic potential such as Lassa and Nipah. We investigate both alignment-based and protein language models to explore the best model of mutation effects across pandemic-threat viral families. We demonstrate the utility of EVEscape in three critical applications: (1) Surveillance …
-
Performance of hot mix asphalt using peat modified asphalt binder
… was conducted to investigate the use of parit Nipah peat (PNpt) to be mixed with asphalt, both of unaged and aged conditions to improve the performance of asphalt mix. The physical properties, storage stability and rheological properties of base asphalt and PNpt modified asphalt (PNpt.M.A.) …
-
Regulation of the Human Parainfluenza Virus (hPIV3) Fusion Protein
… several animal pathogens, such as Sendai virus, Nipah virus and Hendra virus. The creation of effective drugs and vaccines against this family of viruses would play an important role in decreasing the prevalence of these viruses and contributing to the health of both humans and animals worldwide. …
-
Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… including SARS-CoV-2, SARS, Ebola virus and Nipah virus. Genetic positive selection analysis conducted in a recent study has revealed a pattern of antiviral immune genes under positive selection across various bat species. One of these genes is the antiviral restriction factor SERINC3. The …
-
Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… using this system, La Crosse virus (LACV) and Nipah virus (NiV). LACV causes pediatric encephalitis in the United States, while NiV causes severe encephalitic and respiratory disease in Southern Asia. Neuron/astrocyte co-cultures were susceptible to LACV infection and displayed apoptotic …
-
Influence of post-cyclic loading on hemic peat
… and 100 kPa with different location from Parit Nipah, Johor, Parit Sulong, Batu Pahat, Johor and Beaufort, Sabah. These specimens tested using GDS Enterprise Level Dynamic Triaxial Testing System (ELDYN) apparatus. Whereas, dynamic load tests are carried out in different frequencies to simulate …
-
On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… spectrum ranges from emerging viruses such as Nipah virus (NiV), which appear sporadically as local zoonotic outbreaks with high mortality, to continually-evolving endemic viruses such as influenza A (flu). Meanwhile, SARS-CoV-2 is currently transitioning from an emerging to an endemic virus …
-
Spillover and emergence of bat-origin viral infections
This thesis describes four years of research to quantify and characterise the system dynamics of bat-origin viral emergence events. Chapters 2–5 are comprised of four quantitative analyses: a compartmental model comparison of stochastic henipavirus serological dynamics in captive bats (Eidolon …