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Showing 1 to 6 of 6 for “"nifS"”.
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Characterization and site-directed mutagenesis of NifU from Azotobacter vinelandii
… Q (MoFe protein). Two additional genes, nifU and nifS, are required for the maturation of both nitrogenase component proteins. It has been proposed that they may somehow be involved in metallocluster biosynthesis (Jacobson et al., 1989b). Our laboratory has determined that the nifS gene product …
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Biosynthesis of Iron-Sulfur Clusters
… nitrogenase system, it has been proposed that NifS and NifU are involved in the mobilization of sulfur and iron necessary for nitrogenase-specific [Fe-S] cluster assembly. The NifS protein has been shown to have cysteine desulfurase activity and can be used to supply sulfur for the <I>in</I> …
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The Biosynthesis and Function of Nitrogenase Metalloclusters
… point of interest. Inactivation of NifU or NifS has been shown to affect the activity of both nitrogenase components. NifS is a cysteine desulfurase that provides the sulfur for cluster formation and NifU serves as a molecular scaffold during [Fe-S] cluster assembly. Genetic and biochemical …
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Cysteine Desulfurases Mediating Sulfur Trafficking for the Biosynthesis of Fe-S Clusters
… two groups of cysteine desulfurases: group I - NifS and IscS and group II - SufS and CsdA. Tertiary structural signature motifs within these groups provide a rationale for their catalytic differences and specific interactions that occurs between the cysteine desulfurases and sulfur acceptors.
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Role of Gigaxonin in the Regulation of Intermediate Filaments: a Study Using Giant Axonal Neuropathy Patient-Derived Induced Pluripotent Stem Cell-Motor Neurons
… recapitulate this key phenotype. Accumulation of nIFs can be rescued by reintroduction of gigaxonin, by viral delivery or genetic correction. GAN iPS-MNs do not display survival vulnerability in the presence of trophic factors, but do display increased cell death in the presence of oxidative …
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Genes from Arabidopsis involved in iron-sulfur cluster biogenesis
… yeast, and mammals. The key players are the NifS/IscS/SufS proteins, which act as the sulfur donor, and the NifU/IscU/SufU proteins, which serve as a scaffold that binds Fe and upon which the cluster is assembled. Additional proteins are involved in the maturation and transport of the …