Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"nicotinic receptor"”.
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Elucidating the Role of the α7 Nicotinic Receptor in the Etiology of Schizophrenia.
<p>The α7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
The effects of intravenous (i.v.) anaesthetics on nicotinic acetylcholine receptor (nAChR)-mediated transients in intracellular free Ca2+ concentration ([Ca2+]i) and currents were investigated in neonatal rat intracardiac neurons using fura-2 photometry and patch-clamp recordings. Extensive …
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Identification and Characterization of Rare Variants in Cholinergic Nicotinic Receptor Genes and their Contribution to Substance Dependence
… in risk for substance dependence in these nicotinic receptor genes has not been studied.</p><p>In order to investigate the role rare variants play in the development of nicotine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of the <italic>CHRNA5, …
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Neuronal Nicotinic Receptor Dynamics in Medial Geniculate Body Neurons of Young and Aged Fischer Brown Norway Rats
… may then act at pre- and postsynaptic receptors at the level of MGB and function to assign salience to auditory stimuli. The central goal of these studies is to examine the location of nAChRs in the local MGB circuitry, their subunit composition, physiology, and how these properties are …
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The Influence of Alpha7 and Alpha4 Beta2 Nicotinic Receptor Agonists on Feature Based Reversal Learning in Macaque Monkeys
Selective and non-selective nicotinic agonists are associated with improvements in higher order cognitive functions. However, the effects of selectively activating nicotinic sub-receptors on attention and learning are not well understood. In my project, I used two agonists selective for alpha7 (7) …
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Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
… decrease. Cholinergic signals activate the α7 nicotinic receptor in BM mesenchymal stromal cells (BMSCs), leading to increased CXCL12 expression and HSC quiescence. In vivo, exposure to nicotine increases endosteal HSC quiescence and impairs haematopoietic regeneration after HSC transplantation …
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Development of Novel Nicotinic Receptor Mediated Therapeutic Agents: Synthesis and Biological Evaluation of Novel Epibatidine Analogs and the First Total Synthesis of Anabasamine and Related Analogs
… search for a more selective, less toxic neuronal nicotinic acetylcholine receptor analgesic agent in comparison to epibatidine, a series of analogs with hybrid structures of epibatidine and ABT-594 were designed and synthesized. The 1-(pyridyloxymethyl)-7-azabicyclo[2.2.1]heptane ring systems were …
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Single-Channel Studies of Agonist Interactions With the Neurotransmitter-Binding and Pore Domains of the Muscle Nicotinic Acetylcholine Receptor
The nicotinic acetylcholine receptor, a ligand-gated ion channel, is activated by a variety of naturally occurring and synthetic ligands. The overall 'response' elicited by any ligand of the nicotinic receptor is not only a consequence of its binding to the extracellular neurotransmitter-binding …
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Neuronal plasticity in the enteric nervous system motor pathways
… are not yet known. Acetylcholine acting on nicotinic receptors mediates the majority of fast synaptic transmission between enteric neurons, however, recent studies suggest that the peristaltic motor pattern can occur during nicotinic receptor blockade. The aim of this thesis was to determine …
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Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
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Targeted Disruption of Lynx2 Reveals Distinct Functions for Lynx Homologues in Learning and Behavior
… of binding to and functionally modulating nicotinic cetylcholine receptors (nAChR). Lynx1 is a member of the Ly6-α—neurotoxin superfamily (Ly6SF) of genes. Through extensive database searches, I identified 85 members of this superfamily including previously unidentified vertebrate and …
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Examining the Behavioral and Molecular Aspects of Adolescent Nicotine Dependence: Implications for Vulnerability to Drugs of Abuse
… a greater contribution. Specifically, increased nicotinic receptor function is likely to be a substantial contributor to age-related disparities. In addition, nicotine is one of the first and most commonly abused drugs in adolescence and is known to be a strong predictor of subsequent alcohol and …
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Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels. These receptors are present in the central and peripheral nervous systems where they mediate fast synaptic transmission by allowing the flux of cations through the plasma membrane. The heteropentameric α4β2 subtype is the …
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INVESTIGATING THE ROLE OF α6 and α4 CONTAINING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NICOTINE AND COCAINE CONDITIONED PLACE PREFERENCE TESTS IN MICE.
<p>Neuronal nicotinic acetylcholine receptors modulate both cholinergic and non-cholinergic synaptic transmission. Our research concerns α6 and α4 neuronal nicotinic subunits because they often co-assemble with the β2 subunit, which has abundant expression in the CNS and previous work has …
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5 ns Electric pulses evoke longer-lived calcium responses in adrenal chromaffin cells than the physiological stimulus: an experimental and computational study
… pulses evoke longer-lived calcium responses than nicotinic cholinergic receptor activation, the physiological stimulus. In vivo, stimulation of chromaffin cells by acetylcholine causes calcium influx through voltage-gated calcium channels (VGCCs) that increases the concentration of calcium at …
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Modulation of Signal Transduction in the Nervous System by Protein Phosphorylation
… molecular mechanisms by which neurotransmitter receptors transduce their signals: chemically-gated ion channels, receptor-linked ion channels and receptor-linked ion pumps. The nicotinic acetylcholine receptor, a neurotransmitter-gated ion channel, is phosphorylated by a protein tyrosine kinase …
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Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
… alkaloids and certain previously identified nicotinic receptor (nAChR) antagonists, along with growing evidence to support the involvement of nAChRs in various aspects of cancer, provided a rationale to examine the effects of the isolates on nAChRs (Egleton et al., 2008; Schuller, 2009; …
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The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment
… systems in the brain. Arc is involved in AMPA receptor endocytosis in LTD and late phase LTP consolidation at the dendritic fields. NMDA receptor activation increases Arc expression to facilitate synaptic activities and promote remodeling of dendritic spines. AD pathologies can be found in …
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Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs
… having off-target interaction with muscarinic receptors, was performed. Prototypical drugs olanzapine, diphenhydramine, paroxetine were selected for the analysis. Scopolamine and darifenacin were included as positive and negative controls, respectively. Physiochemical properties, …