Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"nicotinic acetylcholine receptor (nAChR)"”.
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
… that certain ligands that interact with DAT, nAChRs, and mGlu2 have tremendous potential as anti-addiction therapeutics. However, understanding how these promising anti-addiction compounds interact with their major drug targets at the molecular level is limited because of the absence of human …
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Expression and Function of Alpha3 and Beta2 Neuronal Nicotinic Acetylcholine Receptor Subunits in HEK-293 Cells
… characterize the mRNA expression of rat neuronal nicotinic acetylcholine receptor (nAChR) subunits α3 and β2 in CA1 hippocampus stratum radiatum and stratum oriens interneurons. α3β2 co-expression was detected in 43% of interneurons analyzed. The nAChR subtype α3β2 was transiently expressed in …
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Synthesis and Evaluation of the Aristotelia Alkaloids at the α3β4 Nicotinic Acetylcholine Receptor
… treatment for stimulant use disorders, the α3β4 nicotinic acetylcholine receptor (nAChR), a key modulator of the brain’s reward pathway, has proven promising. Antagonists for the α3β4 nAChR reduce drug-seeking behavior and withdrawal symptoms in rodent models, but a lack of selective ligands has …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… calbindin, calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real time RT-PCR. …
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CARATTERIZZAZIONE FARMACOLOGICA E FUNZIONALE DI NUOVI LIGANDI DEI RECETTORI COLINERGICI NICOTINICI NEURONALI CHE MODULANO IL RILASCIO DI DOPAMINA NELLA VIA MESOSTRIATALE, UNA VIA IMPORTANTE PER GLI EFFETTI COMPORTAMENTALI DELLA NICOTINA.
The α6β2∗ neuronal nicotinic acetylcholine receptor (nAChR) subtype expressed in the dopaminergic mesostriatal pathway mediates many behavioural effects of nicotine, and is selectively blocked by the small disulfide-rich α-conotoxins PIA and MII. Both share a "ω-shaped" topology but PIA bears a …
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
The a4~2 nicotinic acetylcholine receptor (nAChR) assembles in two alternate forms, (a4p2ha4 and (a4~2hP2, which display stoichiometry-specific agonist sensitivity. Being heteromeric pentameric ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at …
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
… studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, with the nAChR adopting a novel uncoupled conformation in membranes lacking activating anionic and neutral lipids. The lipid-exposed transmembrane alpha-helix, …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
The effects of intravenous (i.v.) anaesthetics on nicotinic acetylcholine receptor (nAChR)-mediated transients in intracellular free Ca2+ concentration ([Ca2+]i) and currents were investigated in neonatal rat intracardiac neurons using fura-2 photometry and patch-clamp recordings. Extensive …
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Computational modeling and simulation of ligand-gated ion channels
… disciplines for more than a century. The muscle nicotinic acetylcholine receptor (nAChR), a member of the pLGIC superfamily, was the first ion channel to be extracted and thus became a model system not only for pLGICs but for all ligand-gated ion channels. Thanks to decades of electrophysiology …
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Atomistic insights into the structure, dynamics, and regulation of integral membrane proteins
… its effective interaction with the surface receptors on the host cell, highlighting functional roles of glycans beyond surface shielding. My second project focuses on the transport mechanism of the human anion exchanger 1 (AE1), a membrane transporter that mediates rapid exchange of …
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Interactions of insecticidal spider peptide neurotoxins with insect voltage- and neurotransmitter-gated ion channels
… and glutamate (Glu-Cl) channel currents and nAChR channel currents. It was revealed that 1 µM ƙ-HXTX-Hv1c failed to modify GABAA channel currents while causing only a moderate 21% increase in Glu-Cl channel currents. Alternately, it was found that ƙ-HXTX-Hv1c caused a concentration-dependent …
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Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
… alkaloids and certain previously identified nicotinic receptor (nAChR) antagonists, along with growing evidence to support the involvement of nAChRs in various aspects of cancer, provided a rationale to examine the effects of the isolates on nAChRs (Egleton et al., 2008; Schuller, 2009; …