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Showing 1 to 20 of 128 for “"nicotinic"”.
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Nicotinic regulation of hematopoiesis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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The Characterisation Of Bee Nicotinic Acetylcholine Receptors
… of commercially important insecticides are the nicotinic acetylcholine receptors. In this study we clone the majority of the Apis mellifera nAChR gene family and putative nAChR chaperones in an attempt to functionally characterise the pharmacological effects of these insecticides. Through the …
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Modulation of Bordetella pertussis by nicotinic acid
Summary available: p. i-iii
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
… suggest that the two major CNS cholinergic nicotinic acetylcholine receptor subtypes a4p2 and a7 may interact directly with Ap and therefore, a multidisciplinary approach has been used to evaluate the reported interaction.
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Nicotinic Acid and Tryptophan Metabolism in the Chick
Made available in DSpace on 2014-12-05T17:47:20Z (GMT). No. of bitstreams: 1 0010474.pdf: 3461934 bytes, checksum: b2bd54ead012d8a3b6a641499b30de51 (MD5) Previous issue date: 1954
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Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
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Regulation and desensitisation studies on the nicotinic acid receptors
The lipid-modifying qualities of nicotinic acid, a B3 vitamin, have been exploited for many years to prevent cardiovascular disease and its associated mortality. Despite its widespread availability and clinical use, the clinical target and precise molecular mechanism by which nicotinic acid acts …
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BETA 2 NICOTINIC ACETYLCHOLINE RECEPTOR CONTRIBUTIONS TO ANXIETY-LIKE BEHAVIOR
… that is thought to promote smoking behavior via nicotinic acetylcholine receptors (nAChRs) in the brain. Given reports that people smoke to relieve anxiety and that anxiety precipitates relapse, the overarching goal of this dissertation research is to assess beta 2 subunit containing nAChR …
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Searching for structural determinants of agonist selectivity in nicotinic acetylcholine receptors
The α4β2 and α7 receptors are the most abundant nicotinic acetylcholine receptors (nAChRs) in the brain, where they contribute to cognition, reward, nociception and mood. They are also implicated in depression, schizophrenia, cognitive deficit and in addiction to nicotine (Nic). Activation of these …
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Influence of a Nicotinic Treatment on Auditory Sensory Processing in Schizophrenia
… stabilization. Nicotine, a non-selective nicotinic acetylcholinergic receptor (nAChR) agonist and the main psychoactive compound in tobacco smoking, is consumed by 60-80% of individuals with SCZ and shown with acute dosing to improve cognitive performance and early auditory information …
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Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
… alkaloids and certain previously identified nicotinic receptor (nAChR) antagonists, along with growing evidence to support the involvement of nAChRs in various aspects of cancer, provided a rationale to examine the effects of the isolates on nAChRs (Egleton et al., 2008; Schuller, 2009; …
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Quantitative Relations Between Tryptophan and Nicotinic Acid in the Baby Pig
Made available in DSpace on 2014-12-04T17:33:06Z (GMT). No. of bitstreams: 1 0013476.pdf: 7522428 bytes, checksum: f2776268008a78f509972aa4c689490f (MD5) Previous issue date: 1955
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Regulation of Expression and Function of Neuronal Nicotinic Receptors by Accessory Subunits
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) and perturbs the biogenesis and trafficking of these channels. The α4β2 and α3β4 subtypes are the most abundantly expressed nAChRs in the central and peripheral nervous system, respectively, and are key mediators of nicotine dependence …
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The role of subunit interfaces in the function of nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors (nAChR) containing α4 and β2 nAChR subunits are the most prevalent type of nAChR in the brain, where they modulate an assortment of physiological functions such as cognition, mood, reward and analgesia. α4β2 nAChRs have been implicated in a wide range of diseases …
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Synthesis and Evaluation of the Aristotelia Alkaloids at the α3β4 Nicotinic Acetylcholine Receptor
… treatment for stimulant use disorders, the α3β4 nicotinic acetylcholine receptor (nAChR), a key modulator of the brain’s reward pathway, has proven promising. Antagonists for the α3β4 nAChR reduce drug-seeking behavior and withdrawal symptoms in rodent models, but a lack of selective ligands has …
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Elucidating the Role of the α7 Nicotinic Receptor in the Etiology of Schizophrenia.
<p>The α7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully …
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