Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"nicotine addiction"”.
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Nicotine Addiction and Impulsive Behaviour: Disentangling the Relationship
Drug addiction can now be considered a global epidemic with considerable psychological, physical, social and economicc osts. Substantial research remains focused upon furthering our understating of the disorder, for which current treatments are limited in their effectiveness. More recently there …
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Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction
Nicotine is the primary addictive substance in tobacco, and most smokers who quit will relapse within a year. Evidence shows that cigarette craving increases over time, termed “incubation.” The purpose of these studies was to see if protracted abstinence from chronic nicotine increases rat …
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Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction
… with severe side effects. As an alternative, nicotine vaccines have emerged as a promising strategy to combating nicotine addiction. However, conventional conjugate nicotine vaccines have shown limited ability to induce a sufficiently strong immune response due to their intrinsic shortfalls. …
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Strain-dependent and age-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.
… in both humans and animals demonstrates that nicotine addiction is a complex disorder that can be influenced by several factors. For instance, individual differences in genetics can impact sensitivity to nicotine and can modulate the severity of nicotine withdrawal. Although nicotine alters …
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NICOTINE WITHDRAWAL AND DEFICITS IN COGNITIVE FLEXIBILITY: POSSIBLE TIES TO ABERRATIONS IN FRONTOSTRIATAL BDNF SIGNALING
Nicotine addiction continues to be a leading cause of preventable death worldwide. Despite the plethora of available treatments for smoking cessation, smoking relapse after attempts to quit remains high. It is possible that impairments in cognitive flexibility and underlying neurochemical circuits …
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THE EFFECT OF NALTREXONE ON NICOTINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS
<p>Nicotine is the central active ingredient in tobacco. The reinforcing effects of nicotine can be studied in animals through self-administration, conditioned place preference, and other approaches that enable researchers to assess nicotine cessation strategies. One strategy involves the use of …
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Effects of Nicotine Pharmacology and Stimulus Expectancies on Withdrawal and Attentional Processing
… of which go beyond the simple pharmacology of nicotine. The current study sought to clarify the independent and potentially interactive effects of nicotine pharmacology and smoking expectancies on self-reported withdrawal symptoms and sustained attention. To this end, the study employed a mixed …
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Haze in the Headlines: Definitional Struggle and the Social Construction of Canada's Vape Mediascape
… for those struggling with tobacco and nicotine addiction and can be seen as an effective smoking cessation tool. This dissertation examines the social construction of vaping. Through the qualitative analysis of media texts, political discourse, and in-depth interviews, this research …
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Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
… disease, epilepsy, Parkinson's disease and nicotine addiction. Because of its key role in the brain and connection to diseases, I sought to understand the basic principles underlying gating, subunit assembly, ligand recognition and ion selectivity of the human α4β2 nicotinic acetylcholine …
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Vaping insights perceptions and experiences on a college campus
… and resources available to prevent a lifetime of nicotine addiction or other tobacco related harm to health. The study addressed research questions in a mixed-methods design. Quantitative research questions included: Does a relationship exist between gender and tobacco consumption following a …
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Predictors of Adolescent E-cigarette Use
… that adolescents may be at particular risk for nicotine addiction, as well as for the neurological, developmental, and behavioral problems caused by nicotine use. The objective of the present study was to identify potential risk factors for adolescent e-cigarette use, particularly those related …
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Neural Mapping of Pain and Addiction: Visualizing Dopaminergic Modulation in the Mesocorticolimbic System
… dictating integral faculties responsible for addiction and nociception, which are heavily intertwined on a fundamental level, primarily due to the dichotomic role of dopamine (DA). The mesocorticolimbic pathway serves as a crucial network for the dissemination of DA, with the dopaminergic hub …
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Computational Evaluation and Structure-based Design for Potentiation of Nicotine Vaccines
… therapeutic options for the alleviation of nicotine addiction have been largely ineffective at stemming the tide of tobacco use. Immunopharmacotherapy, or vaccination, is a promising, alternate therapy that is currently being explored. Results from previous studies indicate that nicotine …
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NICOTINE MODULATION OF THYROID HORMONE SIGNALING AND ITS CONTRIBUTION TO COGNITION
… Thyroid hormones may specifically be affected by nicotine exposure through cigarette smoke. The present work begins with a thorough analysis of the literature on thyroid hormones, their contribution to cognition and synaptic plasticity as well as evidence supporting an interaction between nicotine …
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Cigarette smoking amongst Rheumatoid Arthritis patients in a tertiary centre in South Africa
… about smoking and Fagerström test for nicotine dependence were collated. (1) Results: Of 632 patients (536 females), the mean (SD) age and disease duration were 55.4 (13.0) and 10.1 (9.3) years. The mean (SD) Clinical Disease Activity Index (CDAI) and HAQ-DI were 14.3 (11.8) and 1.5 …
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Development of nanoparticle based nicotine vaccines for smoking cessation
… loss, in recent decades. In recent years, nicotine vaccines that can induce production of nicotine specific antibodies in human have emerged as a promising medicine to treat tobacco addiction. In the past decade, there have been numerous nicotine vaccine candidates evaluated in human …
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS
… approaches to the therapy of nicotinic addiction on one hand and of Parkinson’s disease on the other. Methods - A common strategy was applied to the synthesis of two classes of designed bifunctional derivatives, that is we linked the chosen monovalent fragments with spacers of different …
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