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Showing 1 to 3 of 3 for “"nhaa"”.
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Observing molecular interactions that determine stability, folding, and functional states of single Na+/H+ antiporters
… stability of the sodium/proton antiporter NhaA of Escherichia coli, which serves as a model system for this class of proteins. Mechanical pulling of NhaA molecules embedded in the native lipid bilayer caused a step-wise unfolding of the protein and provided insights into its stability. …
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Mechanical unfolding of membrane proteins captured with single-molecule AFM techniques
… of the membrane protein, i. e. Na+/H+-antiporter NhaA from Escherichia coli. Performed here experiments on NhaA in its functionally active and inactive states demonstrated the advantages of examining unfolding kinetics at the single-molecule level. It was possible to observe unfolding events for …
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Investigation of biological macromolecules using atomic force microscope-based techniques
… Ig25 construct and the membrane protein NhaA. In the latter case, short-lived unfolding intermediates that were populated for less than 10 ms, could be revealed. Conventional single-molecule dynamic force spectroscopy was used to unfold the serine:threonine antiporter SteT from Bacillus …