Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"ngn-1"”.
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Validating ngn-1 transcriptome targets in C. elegans
… a multitude if genetic targets. Neurogenins (Ngns) are a class of deeply conserved basic-helix-loop-helix transcription factor required for fate specification of multiple neuron types and brain structures. Despite its importance in nervous system development and function, the immediate …
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Unraveling the neurogenin/ngn-1 gene regulatory network of C. elegans using classical genetics and comparative transcriptomics
… established regulatory targets of neurogenin(<em>ngn-1</em>) and to identify unknown downstream targets, using the nematode <em>Caenorhabditis elegans</em> as a model for these studies. We find that in <em>C. elegans,</em> neurogenin is required for axon outgrowth, cell fate specification, and …
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A Developmental Pathway for Epithelial-to-Motoneuron Transformation in C. Elegans
… proneural bHLH transcription factors Olig2 and Ngn2, leading to adherens junction loss, delamination from the epithelium, cell migration, and neuronal maturation. A similar sequence of events characterizes formation of pancreatic insulin-secreting β-cells, which are innervated and express genes …
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Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
… CEH-36 and two basic helix-loop-helix proteins NGN-1 and HLH-2 promote the generation of the MI neuron and are required to establish the bilateral asymmetry in this cell lineage. We found that CEH-36 is asymmetrically expressed and is present in an MI precursor cell on the right but not in an …