Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"nfkb"”.
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LncRNA Nostrill Facilitates Neuronal Antiviral Responses by Promoting NFkB-Mediated Irf7 Transcription
… positive neurons in the hippocampus and cortex. NFkB p65-mediated antiviral gene transcription was upregulated by TMEV infection and was correlated with Nostrill expression. In vitro, knockdown studies in neuronal cell lines showed that Nostrill regulated NFkB p65-mediated gene transcription and …
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Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.
Diabetes mellitus (DM) is the most common metabolic disease worldwide. This condition accounts for the majority of renal failure and blindness in adults aged between 20 to 74 years of age. After 20 years, some of type 1 diabetic patients and around 60% of type 2 diabetic patients will be diagnosed …
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Expressão imunoistoquímica de ácido retinóico, CRABP2, NFkB p100 e p105, TRAP1 e TWEAK em nefroblastomas
Resumo: O nefroblastoma, ou tumor de Wilms, é a neoplasia renal mais freqüente na infância correspondendo a 98% dos tumores renais nesta faixa etária. Apesar do prognóstico favorável uma parcela dos pacientes evolui para recidiva e óbito. Biomarcadores atuantes na progressão tumoral, proliferação, …
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The partial characterisation of an NFKB homologue from the South African abalone haliotis midae utilising in vivo and in vitro techniques
Haliotis midae is an important marine gastropod that is commercially farmed along the South African coastline. The demand for the edible foot of the abalone far exceeds the supply, as such monitoring the health status of commercially farmed abalone is important if the demand is to be met. In …
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Charakterisierung von HSS-2, einer B-zellspezifischen, regulatorischen DNA-Sequenz im Bereich des Ig(lambda)-Enhancers des Menschen
… mit Punktmutationen in den beiden NFkB-Bindungsstellen von HSS-2 oder mit 5’- bzw. 3’-Deletionen in HSS-2 eingesetzt. Die Auswertung der Daten ergab, daß der Transkriptionsfaktor NFkB eine sehr wichtige Rolle in der Regulierung des humanen Igl-Locus spielt. Die …
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Muscle catabolism in cancer and its attenuation by eicosapentaenic acid
… involvement of the signal transduction family NFKB in response to PIF in the liver. It has been demonstrated here that both PIF and 15-HETE increased nuclear translocation of NFKB in the skeletal muscle of tumour bearing mice and that EPA inhibited this process by its ability to prevent the …
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The effect of inhibiting KPNB1-mediated nuclear import on cancer cell biology and inflammatory transcription factor signalling
… activity of key transcription factors; NFkB and AP-1, both having been implicated in many of the hallmarks of cancer. Immunofluorescent analysis and nuclear/cytoplasmic fractionation assays showed that KPNB1 inhibition blocked the nuclear localisation of NFkB. Electromobility shift …
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Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays
… expressed nuclear factor κB response element (<i>Nfkb</i>-RE)/GFP, fatty acid binding protein 4 promoter (<i>Fabp4</i>-P)/CFP, and nuclear factor erythroid 2-related factor2 promoter (<i>Nrf2</i>-P)/YFP fluorescent reporters. We hypothesized that fluorescent signals directly correlated to …
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Inhibition des 26s Proteasoms : molekularer Mechanismus der Hyperthermie in Prostatakarzinomzellen?
… die 26s Proteasomenaktivität, die NFkB-Signaltransduktion und die Androgen-Rezeptor-Expression von Prostatakarzinomzellen beeinflußt. <br>Humane PK- (PC-3, LNCaP, DU-145), Glioblastom- (A172), Melanom- (A375) und Bronchialkarzinomzellen (A549) und murine PK-Zellen (TRAMP C1, TRAMP …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… protein tyrosine nitration, activation of the NFkB, and upregulation of ICAM-1/VCAM-1 expression. To test the role of caveolae in this process, cultured cells were depleted of caveolin-1 (siRNA). Similar to inhibitors, TNFα failed to induce protein-tyrosine nitration, activate NFkB or enhance …
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Studies of TNF- α-induced -GSIS Inhibition in INS-1 β-cell
… inhibition. Decreased GSIS was recoverd by SN50, NFkB inhibitor. TNF-α-induced NFkB activation is thought to be reponsible for TNF-α-induced GSIS inhibition. CONCLUSION: Glucose and insulinotropic stimuli-aminoacid, sulfonylurea, imidazolin-induced insulin secretion was significantly suppressed by …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… of IL-1α-induced nuclear localisation of the NFkB transcription factor p65 but significantly increased IL-1α-induced p65 binding to the IL6 promoter, correlating with reduced H3K9me2 levels. In contrast, enrichment of p65 was not observed at reported NFkB sites within the MMP3 promoter after …
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Expresión y significación clínica de las citoquinas en el cáncer de mama
… las citoquinas IL-1, IL-5, IL-6, IL-17, IFN-ß y NFkB en carcinomas ductales invasivos de mama de 108 pacientes por un método inmunohistoquímico, analizando su expresión por las células tumorales, los fibroblastos y las células mononucleares inflamatorias (CMIs) del estroma tumoral, y su …
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Identifizierung und Charakterisierung von Zielgenen des Epstein-Barr Virus nukleären Antigens 2 (EBNA2)
… Proliferation ist sowohl mit der Aktivierung des NFkB-Signalwegs assoziiert, als auch mit der verstärkten Expression zentraler Komponenten der Interferon (IFN)-Antwort (insbesondere STAT1) und mit der Repression von Komponenten des B-Zell-Rezeptors (BCR) und der BCR-Signaltransduktion. Die …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… on MAP kinases p38, ERK and JNK as well as NFkB transcription factor, whereas CCL5 production required PI3/Akt and NFkB
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Klonierung der cDNA des Protein A Kinase-Adaptor-Proteins-2 und Untersuchungen zur Regulation seiner mRNA in humanen fötalen Osteoblasten
… Stoffe wirken u.a. über den Transkriptionsfaktor NFkB. Andere Faktoren wie die Phosphatidylinositol-3-Kinase und cAMP dagegen scheinen keine Relevanz für die Expressionsinduktion der mRNA zu haben. TNFa spielt im Knochenstoffwechsel eine wichtige Rolle bei Osteoklastenaktivierung, …
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Charakterisierung und in vitro - Wirkung agonistischer AT1-Rezeptor Autoantikörper bei Präeklampsie-Patienten
… die Transkriptionsfaktoren AP-1 und NFkB aktivieren. Die Aktivierung des Transkriptionsfaktors NFkB wurde vornehmlich in den Nicht-Myozyten der Rattenherzzellkultur nachgewiesen. Generell wurde festgestellt, dass sich die AT1-AAK pharmakologisch wie der natürliche Agonist des …
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Genetic analysis of thymocyte apoptosis
… regulation of GSTM1 and Nur77 transcription, and NFkB function was also tested in the Dex-resistant cell lines. GSTM1 expression was not induced in the Apt- cell lines by Dex. TNF a -induced activation of NFkB function was not observed in Apt3.8, and GR-dependent repression of Nur77 expression is …
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Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… Tollip may serve as a negative regulator of NFkB signaling pathway in cells challenged with higher dosages of LPS, it acts as a positive regulator for low-grade chronic inflammation in leukocytes programmed by subclinical low-dosages of LPS. We aim to show recent progress in our understanding …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… publizierten Daten konnten wir eine Hemmung der NFkB-Aktivität durch das C-terminale HPK1-Peptid nachweisen, das die IkBalpha-Degradation inhibiert. Die erzielten Ergebnisse führten uns in ihrer Gesamtheit zu folgendem Modell: während der Initiationsphase der T-Zell-Stimulierung werden nach …
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