Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"nextgeneration sequencing"”.
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Innovative molecular methods for fish species differentiation
… L. erythropterus (Bloch, 1790) were analyzed by nextgeneration sequencing. The mitochondrial DNA sequences of both museum type specimens were found to be 99.77% similar. These results suggest that both investigated type specimens belong to the same species. For the authentication of the snapper …
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CRISPRI-based high-throughput functional genomic approaches for use in mycobacteria
… functional genome, such as transposon-insertion sequencing, have been developed and applied to mycobacteria in a variety of conditions; however, they have several limitations, particularly in their ability to study genes essential for viability. The recent optimisation of inducible …
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A Census of Human RNA-Binding Proteins and Characterization of the DEDDh RNA Exonuclease NEF-sp in the 3' End Maturation of 28S Ribosomal RNA
… Recent large-scale quantitative methods such as nextgeneration sequencing and modern protein mass spectrometry enabled new approaches to dissect PTGR networks and renewed interest in investigations of factors involved in PTGR at a genomewide level. A census of all coding and noncoding RBPs has …
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The chromatin landscape of colorectal cancer cells
… technological advances in next-generation sequencing approaches have offered unprecedented opportunities to interrogate the genomic landscape in multiple pathological and clinical presentations. Historically, mutations and alterations at the genomic loci of protein-coding genes were thought …
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Lymphoma: Understanding the diagnostic challenges and improving outcomes in a TBand HIV-endemic area
… diagnostic modalities, including the use of nextgeneration sequencing, are evolving rapidly and informing both prognosis and therapy in the field of lymphoma. These modalities of testing are likely to mean that less tissue is needed for assessment, or even that diagnosis can be made from …
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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes
… understanding of gene function. High throughput sequencing now makes it practical to exploit reverse genetics to simultaneously study functions of thousands of normal sequence variants and spontaneous mutations that segregate in intercross and backcross progeny generated by mating completely …