Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"next-gen sequencing"”.
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Investigating how bat ectoparasites influence the skin microbiome diversity and composition in Washington State bats
… Syndrome (WNS), caused by the psychrophilic pathogenic fungus Pseudogymnoascus destructans (Pd), has killed millions of bats in the eastern United States since its initial introduction in 2006 and recent expansion into the western U.S. Understanding factors that contribute to the spread of Pd and …
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Microfluidic platforms for Transcriptomics and Epigenomics
… life, stores a plethora of information in its genome, epigenome, and transcriptome which needs to be analyzed via various Omic studies. The heterogeneity in a seemingly similar group of cells is an important factor to consider and it could lead us to better understand processes such as cancer …
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Engineered microsystems and their application in the culture and characterization of three-dimensional (3D) breast tumor models
… blank-slate matrix consisting of thiolated collagen, hyaluronic acid and heparin, cross-linked chemically via Michael addition reaction using diacrylate functionalized poly (ethylene glycol). The hydrogel network was used with triple-negative breast cancer cells and showed significant changes in …
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The spatial and temporal regulation of the transcriptome during plant development
… seedling undergoes organ-specific photomorphogenic development when exposed to light. The cotyledons open and expand, the apical hook opens and the hypocotyl ceases to elongate. Using the large and easily dissected seedlings of soybean (Glycine max cv. Williams 82), we show that genes involved …
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Evolution of the aquatic beetle family Noteridae (Coleoptera: Adephaga): integrating methods to examine patterns of diversification across temporal scales.
… old. Adephaga has been the subject of many phylogenetic investigations using a variety of data types, without strong consensus on the relationships of its aquatic members. We conducted the first phylogenomic study of Adephaga with ultraconserved elements (UCEs). UCEs are captured by targeted, …
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Somatic microsatellite variability as a measure of DNA stability in cancer and DNA repair disorders
… developed a novel approach to extract MSTs from next-gen sequencing data that can robustly detect signatures of MST mutation bias and somatic variation occurring in next-gen data including a high frequency of in-phase indels. Somatic variability, novel genomic polymorphisms that arise within a …
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Nutrient Cycling Between Litters and Soil after Fire in Native Woodland and Pinus radiata Plantations
… thermal alteration of pine needles on soil nitrogen cycling and the soil microbial biomass. The materials for this work were generated from forestry reserves that had recently been exposed to an uncontrolled fire. These reserves included Eucalyptus woodlands (‘native’) and Pinus radiata …
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Comparative Analysis of Heterochromatin in the Anopheles gambiae Complex
… health and quality of life. Advances in the genome sequencing in the past decade have helped to uncover numerous secrets of diverse genomes. The genome of malaria mosquito Anopheles gambiae was first sequenced in 2002 and since then has been updated to include additional scaffolds, their …
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Population genetic frameworks and functional genomics of Mycobacterium bovis
… or M. bovis, "the world's most successful pathogen", the majority in developing countries. The global spread and increasing severity of tuberculosis are due in part to the high number of individuals infected with HIV, and in part to the increasing intensity of human-animal interactions as land …