Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"new therapeutics"”.
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A Financial Model to Assist New Therapeutics Development Decision Making
Biotech is an industry that is heavily reliant on the risky Research and Development process. While the biotech projects are most often valued with Discounted Cash Flow (DCF) methods, the risk and the phased development process of the biotech industry make it an ideal process to be valued by a real …
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Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse
… and pharmacokinetics in the development of new pharmacotherapies, CM304 (sigma-1 receptor antagonist), mitragynine and 7-hydroxymitragynine (μ-opioid receptor agonists), for the treatment of drug abuse. The affinity of cocaine to sigma-1 receptors render the hypothesis that targeting sigma-1 …
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In Silico-Guided Design of Novel-Scaffold Therapeutics Targeting the Dopamine D3 Receptor
… of relevant drug receptors in the brain. A new computational technique, de novo fragment-based drug design (DFDD), was evaluated employing a dopamine D3 receptor (D3R) crystal structure. Three DFDD approaches - scaffold replacement, ligand building, and MedChem Transformations - were …
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The conformational landscape of RNA translational regulators and their potential as drug discovery targets
… will increasingly become integral to designing new therapeutics targeting RNA.
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Modeling of Therapeutic Drugs, Polymers, and Self-Assembling Peptides
… experimental groups on designing and testing of new therapeutics and peptide-based materials. In particular, we conducted atomistic molecular dynamics simulations to study systems in three main areas: A) small drugs and therapeutic polymers, B) therapeutic peptides, and C) materials based on …
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The Interictal State In Epilepsy And Behavior
… a molecularly-accurate model on which to test new therapeutics. Finally, we show that interictal spikes are associated with behavioral changes in this animal model and that a targeted inhibitor can both prevent the development of a spiking focus and normalize behavior.</p>
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Studies on a bioactive peptide QUB-2044 from the skin secretion of the Chinese frog, Odorrana schmackeri
… been recognised as the most bountiful source for new therapeutics, among which amphibians have been the focus of research in the search for new compounds with biological activities as a result of the abundant bioactive contents of their skins. So far, a great number of pharmacological and …
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Microfluidic platforms for studying cell behavior
… the two processes will aid in the development of new therapeutics. However, conventional methods used to study chemotaxis and intercellular signaling have limited control over the microenvironment. Control over the microenvironment is required to generate multiple independent gradients and …
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Cell-free platform for the functional characterization of intracellular ion transporters
… used as invaluable tools for the development of new therapeutics. However, honing down on the structural and functional properties of membrane proteins is no easy feat, owing to challenges in expression, purification, and the availability of high-throughput functional readout methods. …
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Non-conventional Regulation of Treg Development and Function
… surgical treatment. Hence, the development of new therapeutics is an utmost priority. Tregs are vital in maintaining immunological tolerance and preventing inappropriate inflammatory responses. Despite having no obvious functional defects, Tregs are unable to regulate inflammation in human IBD …
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Molecular recognition from atomic interactions: insights into drug discovery
… industry to increase the delivery of new drugs into the market is driving a re-assessment of practices and methods in drug discovery and development. In particular alternative strategies are being pursued to find therapeutics that are more selective, including small molecules that …
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Novel Immunometabolic Therapies and Prognostic Markers for Lymphedema
… chronic irreversibility of this clinical entity. New therapeutics are needed to target lymphedema fibrosis, and improved prognostic models are required to reliably predict who will develop chronic, severe lymphedema to appropriately triage and monitor patients for timely diagnosis and treatment. …
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Ultrafast infrared spectroscopy investigation of DNA-ligand interactions
… DNA is relevant in the development of potential new therapeutics that target specific DNA sequences to influence a biological process. The conception of a 2D-IR screening experiment will therefore allow for an assessment of sequence-specific ligand interactions across multiple different binding …
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Characterization and Inhibition of the Dimer Interface in Bacterial Small Multidrug Resistance Proteins
… represent a valuable route to the discovery of new therapeutics.
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Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)
… with small molecules has been identified as a new method to directly influence the phosphoinositide 3-kinase (PI3K) cell signaling pathway. Modulation of this pathway may be utilized in the development of interesting new therapeutics. A better understanding of the role that SHIP phosphatase …
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Molecular Mechanisms and Host Factors Involved in HIV-1 Latency
… latency and further help in the development of new therapeutics.
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Design and Synthesis of Antimycobacterial Agents
… compound libraries failing to produce new therapeutics. This has led to a renewed interest in utilising phenotypic screens, but rather than applying them to natural product libraries and running the risk of rediscovering known antibiotics, applying them to novel compound libraries which …
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Efficacy of Antibody and T cell Therapies for Highly Mutable Viruses like Human Immunodeficiency
… Our results will help guide the design of new therapeutics, and provide a platform for future computational screening of of the efficacy of new treatment regimes.
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A multilayer network approach to quantifying biologically-derived systematic risk in biomedical finance
… evidenced by the stagnation and even decline of new therapeutics development success rates. Recent work in the MIT Laboratory for Financial Engineering has explored the potential of using financial engineering in the form of biomedical "megafunds" to help tackle this problem. New methods will be …
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Identifying and Inhibiting Cholesterol-Protein Interactions for Therapeutic Development
… and inflammatory bowel disease and develop new therapeutics designed to target specific cholesterol-protein interactions. First, we introduce a new method using Turbo ID proximity labeling paired with site-specific modulation of the cholesterol concentration to identify new …
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