Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 462 for “"neutrophils"”.
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Role of Monocytes and Neutrophils in Thrombosis
… closely with leukocytes such as monocytes and neutrophils and modify their activity. This thesis aims to identify novel mechanisms through which leukocytes and platelet-leukocyte interactions might contribute to thrombosis. The thesis focused on rapid interactions between these cells (on the …
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Neutrophils in advanced non-small cell lung cancer
… responses contribute to cancer progression. Neutrophils are active players in the metastatic environment, but there is limited data regarding human neutrophil populations in advanced lung cancer. Greater understanding of the interplay between extrinsic cell signals and intrinsic cell features …
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Resolvin E1 actions on polymorphonuclear neutrophils in diabetes
Diabetes and periodontal disease exhibit a bidirectional relationship centered on an enhanced inflammatory response manifested both locally and systemically. The observation that hyperglycemia by itself, in the absence of additional inflammatory signals, promotes a proinflammatory environment …
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Human neutrophils generate extracellular vesicles that modulate their functional responses
Neutrophils influence innate and adaptive immunity by releasing various cytokines and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed ectosomes, which influence the function of other …
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The Effect of Acute Exercise on Neutrophils and Oxidative Stress.
<p>This study tested the hypothesis that high intensity exercise, independent of total oxygen consumption, results in the most significant elevations in neutrophil (PMN) counts and blood oxidative stress (OS). This study also tested the hypothesis that active individuals have a blunted PMN and OS …
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Efficient Methods for Ex Vivo Generation of Gene-edited Neutrophils
Neutrophils are the most numerous circulating leukocyte in humans and are key first responders to invading pathogens and effectors of tissue repair and homeostasis. The potent antimicrobial functions of mature neutrophils are tightly controlled due to their potential for tissue damage, and thus …
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Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade
Acute Respiratory Distress Syndrome (ARDS), an age-old clinical problem facing the Emergency Department and Intensive Care Units of all health systems, is a common debilitating lung condition consequent upon severe systemic inflammation. Although several studies have gone into understanding the …
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Understanding the Effect of BVDV on Innate Immune Response of Neutrophils
… has been done to determine the effect of BVDV on neutrophils. Neutrophils are one of the most abundant while blood cells (WBC) in the peripheral blood, which play a critical role in the innate as well as adaptive immune response. The current study measured the effect of BVDV infection on viability …
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An unbiased proteomic approach to identifying cell surface markers in neutrophils
… engulfment of dead cells by phagocytes such as neutrophils and macrophages and culminates in the beneficial removal of inflammatory cargo and auto-reactive material. While many of the mechanisms involved in efferocytosis have been described, the critically important ‘apoptotic-cell-associated …
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
… paradoxical increase in the adhesion of Tiam1–/– neutrophils (unpublished). This was surprising, as deficiencies in other neutrophil Rac-GEFs impair adhesion. I showed deregulated neutrophil polarisation, Filamentous-actin (F-actin) polarity, F-actin dynamics and focal adhesion structures in …
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… (PMN-MDSC) gene signature in tumor associated neutrophils (TANs). Importantly, in vivo treatment with αGalCer restored tumor control and iNKT cell cytotoxic functions. Survival analyses of human CRC patients showed that co-infiltration by iNKT cells and TANs led to unfavorable prognosis. Our …
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Doxorubicin-Induced Cardiotoxicity Is Mediated By Neutrophils Through Release of Neutrophil Elastase
… and innate immune cells, in particular neutrophils. Recognizing that neutrophils have been implicated in a number of heart diseases, we evaluated the role of neutrophils in Dox-induced cardiotoxicity. Here, using echocardiography, flow cytometry and immunofluorescence staining, we …
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Investigating the role of endoplasmic reticulum stress in neutrophils during tumour initiation
Neutrophils are pivotal innate immune cells conventionally recognised for their rapid response to infection sites. In recent years, immune suppressive and tumourpromoting neutrophils were found enriched in the tumour microenvironment, suggesting their role in driving the development of cancer. …
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Modulation of Brain Inflammation Induced by Interaction between Astrocytes, Neutrophils and Monocytes
… RESULTS 16 A. Interaction between astrocytes and neutrophils 16 1. Effect of neutrophils on morphology of astrocytes 16 2. Effect of neutrophils on inflammatory responses of astrocytes 18 B. Interaction between astrocytes and monocytes 20 1. Effect of THP1 cells on morphology of astrocytes 20 2. …
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Multi-omic Studies of Neutrophils Reveal Programmed Deactivation Phenotypes After Inflammatory Stimulus
Neutrophils serve as a critical first line of defence against bacterial invasion, and their dysfunction is associated with unfavourable clinical outcomes. A detailed understanding of the activation and resolution pathways that modulate neutrophil interactions with bacteria, as well as the …
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The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro
… model by elucidating its effects, in isolated neutrophils and monocyte-derived macrophages from piglets. Our findings indicate that TYL increases porcine neutrophil and macrophage apoptosis in a dose-dependent and time-dependent manners, without affecting levels of necrosis. TYL also modulates …
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Understanding how neutrophils self-organise their migration to sites of inflammation in vivo
Neutrophils are major effectors of acute inflammation and microbial defence. Their infiltration and migration in injured tissue are critical for the inflammatory response. They are often observed navigating in a highly co-ordinated and directed manner leading to their aggregation at the target site …
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Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
… bacterial killing and phagocytosis by isolated neutrophils, through mechanisms that do not rely on its catalytic function. Specifically, P-Rex1 promotes the phagocytosis of IgG-opsonised zymosan particles and supports both integrin- and Fc receptor-dependent uptake independently of its Rac-GEF …
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