Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"neutrophilia"”.
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Comparative efficacy of three common treatments for equine recurrent airway obstruction
… ENV resulted in a significant decrease in airway neutrophilia that was maintained throughout the treatment period. In contrast, treatment with DEX caused a reduction in airway neutrophilia initially followed by a rebound neutrophilia as the period between administrations of dexamethasone …
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Lithium-Carbonate as a Protectant Against Chemotherapy-Induced Myelosuppression
… of action have been considered. Lithium causes a neutrophilia and may protect the bone marrow against the toxic effects of myelosuppressive drugs.
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Characterisation of physiological and immune-related biomarkers of weaning stress in beef cattle
… for 35 days post weaning. In cows, transitory neutrophilia (increase in neutrophil number) and lymphopenia (decrease in lymphocyte number), reduced interferon-γ production, and increased concentrations of acute phase proteins were evident post weaning, whereas post-housing, changes were less …
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Effects of Daily Oral Injections of Quercetin on Implanted Colon-25 Tumor Growth in Balb-C Mice
… same dosages of quercetin all produce a profound neutrophilia combined with a significant lymphopenia at day 20 post-implantation, and (3) there was relatively little evidence of histological changes in the quercetin-treated tumor section which would indicate that the action(s) of quercetin is …
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Determinants of smoke induced lung damage and relationship with metabolic syndrome
… measures of lung density/emphysema, only sputum neutrophilia (both absolute and percentage counts) predicted the annual decline in FEV1. In summary, this study suggests that there is an increased prevalence of MeS in smokers associated with insulin resistance caused by smoking but it fails to …
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The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice
… differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators.
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Comparison of Airway Response in Recurrent Airway Obstruction-Affected Horses Fed Steamed Versus Non-steamed Hay
… in clinical score and a trend towards airway neutrophilia, while parameters were unchanged in horses fed steamed hay. Only horses fed non-steamed hay experienced a significant increase in tracheal mucous score. Horses fed steamed hay gained significantly more weight compared to horses fed …
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Development of a Murine Model of Severe Scrub Typhus And Its Use to Elucidate the Immune Response to and The Pathology that Occurs during Orientia Tsutsugamushi Infection.
… studies that report blood cell counts, describe neutrophilia during the course of infection and observed in our model, suggesting key a role in scrub typhus. To determine the role of neutrophils in this infection, mice were lethally challenged, and neutrophils were depleted one day prior to and …
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Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal Pneumonia Virus of Mice.
… nasal discharge, and difficulty breathing due to neutrophilia, edema and alveolitis in the lower airways. Also, these mice will succumb to the infection between days 6 and 7 p.i. Immunomodulation mediated by a novel formulation composed of the toll-like receptor 3 agonist poly I:C, an innate …
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Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
… mice. Results demonstrate OPN-mediated pulmonary neutrophilia and airway destruction in Ada -/- mice. Furthermore, patients with COPD exhibit increased OPN in airways which correlate with clinical airway obstruction. These results suggest OPN represents a novel biomarker or therapeutic target for …
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Optimization and analysis of lipid nanoparticles for in vivo mRNA delivery
… innate immune response to mRNA-LNPs, including neutrophilia, myeloid cell activation, and up-regulation of four serum cytokines. Although we have developed a more efficacious liver-targeting LNP, many mRNA therapies will require delivery to non-liver tissues. Using trial-and-error approaches, we …
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Relationship between surfactant alterations and severity of disease in horses with recurrent airway obstruction (RAO)
… Supernatant protein content was related to BALF neutrophilia in RAO crisis and overall ΔPplmax . In conclusion, our study demonstrated that surfactant alterations in RAO horses are present in remission and are exacerbated following exposure to hay. It is conceivable that a lower amount of …
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The host response to cancer and cancer-associated cachexia
… tumour growth. In the second chapter I describe neutrophilia as an early event during cancer progression. Transcriptomic and metabolic assessment reveals that neutrophils in tumour-bearing animals utilize aerobic glycolysis, similar to cancer cells. Although pharmacological inhibition of aerobic …
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The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… (HSPC) expansion that underlies monocytosis and neutrophilia, coinciding with increased cell surface expression of the common β subunit of the Granulocyte-macrophage colony-stimulating factor (GM-CSF) /Interleukine 3 (IL-3 receptor (CBS) in the bone marrow HSPCs and increased GM-CSF production in …
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Soy isoflavones and swine health
… PRRSV infection by reducing PRRSV-induced band neutrophilia and improving cytotoxic-to-helper T-cell ratios with only a few interactions occurring between soy protein type and isoflavones supplementation across all remaining immune measures collected. These results suggested that isoflavones, …
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Cellular innate immune responses to lung resection via video- assisted thoracoscopic surgery (VATS) and thoracotomy : predictors of post-operative pneumonia
… post-operative leucocytosis due principally to neutrophilia. A relative blood lymphopenia and thrombocytopenia developed postoperatively (p<0.0005). VATS was associated with a lower fall in serum albumin (p=0.001). BALF from the non-operated lung became more pro-inflammatory immediately …
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Respiratory complications of organophosphorus pesticide poisoning
… oedema, pulmonary haemorrhage and modest neutrophilia with increased concentrations of protein, IL-6 and IL-8 when compared with controls, but with low concentrations of TNF-α and IL-10 in bronchoalveolar lavage fluid (BALF). In a second study, OP poisoned minipigs had increased …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… This response is consistent with the short-term neutrophilia and leukocyte activation that has been observed in response to multiple stressors such as weaning and transportation in cattle. Similar responses were observed in activated neutrophils in response to NE. My research also demonstrated a …
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The Comparison of Airway Responses of Normal Horses Fed Round Bale versus Square Bale Hay
Background – Feeding horses round bale hay (RBH) has been associated with airway inflammation. The purpose of this study was to determine if horses fed RBH for a 6-week period demonstrated more evidence of airway inflammation than horses fed square bale hay (SBH) of comparable quality. Hypothesis - …