Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"neutrophil recruitment"”.
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Mechanisms of neutrophil recruitment in septic lung injury
… intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. The aim of thesis was to prevent excessive neutrophil …
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
Neutrophils are innate immune cells and the first to be recruited to sites of injury, where they are essential for host defence. Defective neutrophil recruitment can inhibit pathogen clearance, while impaired neutrophil resolution can lead to chronic inflammation. Therefore, it is essential that …
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Role of interleukin-8 monomer-dimer equilibrium and glycosaminoglycan interactions in neutrophil recruitment
… (IL-8) is a proinflammatory chemokine, recruits neutrophils as a host response to infection and tissue injury.. An imbalance in the recruitment process has been attributed to a variety of autoimmune and inflammatory diseases. Knowledge of in vivo IL-8„ŸGAG interactions is one of the first steps …
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Inflammation and neutrophil recruitment in ageing subjects and patients with chronic obstructive pulmonary disease
The neutrophil is central to the development of COPD. To enter lung, neutrophils must migrate accurately from the circulation to inflamed tissue. It is unclear which migratory stimuli are important and whether COPD neutrophils vary in their migratory behaviour, either to controls or patients with …
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In Vivo Imaging of Neutrophil Responses to Localized S. aureus Infection
… majority of soft tissue infections. The role of neutrophils in S. aureus soft tissue infections is currently unclear. The objective of this thesis was to characterize early neutrophil recruitment to a localized MRSA infection. Using spinning disk confocal microscopy, we developed a mouse model to …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… Lm infection, CysLTR1 deletion led to increased recruitment of neutrophils to the liver and spleen, while in female Cysltr1-/- mice during Mtb infection, lung neutrophil recruitment was elevated. In Balb/C mice, CysLTR1 deletion during Lm infection affected survival in a sex-dependent manner, …
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Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis
… pathogenic bacteria from the host. Early neutrophil recruitment is a critical step in a multistep requence leading to bacterial clearance. Pattern recognition receptors (PRRs) play a critical role in the innate immune system. Receptor interacting protein 2 (RIP-2) is an adaptor for the …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… by fibrosis. Previous studies revealed that neutrophils are recruited into the lung via a MyD88- dependent pathway and regulate disease severity through cytokine production. Toll-like receptors (TLRs) 2 and 9 recognize conserved molecular patterns present in bacteria, and signal through the …
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The role of mast cells in a mouse model of focal cerebral ischaemia
… brain barrier (BBB) permeability, oedema and neutrophil recruitment. Therefore the hypothesis of this thesis was that mast cells are active in the acute phase of experimental focal cerebral ischaemia, and interact with the brain to potentiate ischaemic pathology by release of a plethora of …
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Rgg2/Rgg3 Quorum Sensing in Streptococcus pyogenes and Innate Immune Cell Responses
… species production, chemokine production, and neutrophil recruitment are all suppressed. Expression of the Rgg2/Rgg3 quorum sensing system allows S. pyogenes to suppress these innate immune responses. Altogether, the results from these chapters explores how the immune system and microbial …
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Cathepsin S as a mediator of acute lung inflammation
… strategies in ARDS have focussed on the neutrophil serine protease, neutrophil elastase (NE). Although in clinical use in Japan, NE inhibitors have not proven effective and other protease targets warrant investigation. The cysteine protease, cathepsin S (CTSS), is emerging as an …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… in ion transport, antibacterial defense, and neutrophil recruitment. At the functional level, bronchial epithelia treated in vitro with the cytokine combination showed upregulation of ENaC channel, ATP12A proton pump, ADRB2 β-adrenergic receptor, and SLC26A4 anion exchanger. The overall result …
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Immune Mediators of Murine Lyme Arthritis
… found that the chemokine KC is responsible for neutrophil recruitment and subsequent development of Lyme arthritis and carditis. This was the first study to describe an immunological regulatory mechanism mediating disease susceptibility to murine Lyme disease, as resistant mice (B6) produce less …
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Development of a direct photochemical method for the generation of biomolecular interfaces for applications in leukocyte biology
… endothelium, were applied to flow assays with neutrophils isolated from whole blood for investigating the effects of bromelain, an alternative anti-inflammatory treatment, on neutrophil recruitment in vitro under conditions of physiological shear stress. Beyond applications in leukocyte …
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Adhesive and signaling mechanisms in abdominal sepsis
… of LFA-1 or Mac-1 not only reduced neutrophil infiltration but also protected against sepsis-caused lung damage. We observed that HMG-CoA reductase inhibitor regulates pulmonary accumulation of neutrophils via antagonizing CD40 ligand secretion from platelets and via decreasing CXC …
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A Larval Zebrafish (Danio Rerio) Model of Adherent-Invasive Escherichia Coli Infections
… further exacerbated by AIEC, resulting in higher neutrophil recruitment to the gut and increased relative expression of the genes that encode proinflammatory cytokines. In addition, we showed that two AIEC virulence factors, FimH and IbeA, play a role in AIEC colonization and contribute to …
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The role of vector-derived microbiota and co-localization in the dissemination of vector transmitted pathogens
… of sand fly gut-derived (SFGD) bacteria on neutrophil recruitment, IL-1β production, and parasite dissemination in both wild-type and IL-1β-deficient mice. Our findings reveal an enhanced influx of neutrophils IL-1β+ in the early stages of infection, underscoring the importance of …
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TOWARDS AN IN VITRO MODEL FOR RNA INTERFERENCE- MEDIATED SUPPRESSION OF S100A8
… heterodimeric partner, S100A9, are expressed by neutrophils and monocytes and secreted to the extracellular milieu during inflammation where they act as potent chemokines for neutrophil recruitment. The aim of this study was to assess the efficacy of short-hairpin RNAs (shRNAs) in suppressing …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… mechanistic process which is triggered by neutrophils and tissue resident macrophages releasing various factors or cytokines to restore lung homeostasis. Recent research has highlighted some important evidence that the inflammasome may be a key player in lung injury progression. …
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