Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 448 for “"neutrophil"”.
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Neutrophil Regulation of Colitis
… a crucial component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial barrier is breached and gut microbiota invade. Although accumulation of neutrophils in the intestine is correlated with inflammatory bowel disease (IBD), …
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Quantitative Image Analysis in the Study of Neutrophil and Neutrophil-Like HL-60 Chemotaxis
Neutrophils are fast-moving first responders of the innate immune system. External chemoattractant signals result in neutrophil polarization: the neutrophil forms a leading edge (front) which constantly protrudes and retracts actin-rich pseudopods, and a contractile myosin-enriched trailing edge …
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Neutrophil extracellular traps in periodontitis
This thesis has investigated the role of neutrophil extracellular traps (NETs) in the pathogenesis of periodontitis. A fluorometric assay was developed for the in vitro quantification of NET release and used to assess relative levels in chronic periodontitis patients, indicating elevated release …
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Human Cytomegalovirus and the Neutrophil
… and release of new virions, but not the neutrophil. This cell is the first immune cell to engage most pathogens, engulfing and killing them before undergoing apoptosis and clearance by macrophages. However certain viruses and bacteria are able to evade host defences and use the neutrophil …
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Neutrophil diversity in immunity and inflammation
Contains fulltext : 239947.pdf (Publisher’s version ) (Open Access)
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Roles of Neutrophil Activation in Asthma
Background: Neutrophilic inflammation has been implicated in allergic asthma as well as occupational asthma, which is usually associated with severe phenotype. Autophagy plays crucial roles in innate as well as adaptive immune responses by contributing to the proliferation, activation and …
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Bovine Neutrophil Functions and Periparturient Disorders
Neutrophil functions in periparturient normal cows (n = 46), and their relationship with the occurrence of retained placenta and metritis complex (RPM, n = 20), metritis (n = 18) and mastitis (n = 13), were studied by collecting blood samples via jugular vein twice weekly from 1 week before to 4 …
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Neutrophil Chemotaxis in Multiple Chemoattractant Gradients
… class of leukocytes (white blood cells) known as neutrophils, which normally circulate in the bloodstream. Upon activation, these cells emigrate out of the vasculature and navigate through interstitial tissues toward target sites. There they phagocytose bacteria and release a number of proteases …
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Modulation of neutrophil degranulation by hypoxia
Neutrophils are key effector cells of the innate immune system. They employ a number of powerful ‘weapons’ to eliminate pathogens, including an array of destructive proteins packaged into distinctive granule subsets. In addition to their microbicidal activity, these granule proteins are capable of …
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Mechanisms of Neutrophil Exhaustion and Resolution
… complications due to chronic immune dysfunction. Neutrophils, the most dominant leukocytes in human circulatory systems, play a critical role in not only promoting inflammation to fight against microbe invasion but also facilitating inflammation resolution to restore immune homeostasis. While …
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Aging Exacerbates Neutrophil Pathogenicity In Ischemic Stroke
… unknown.</p> <p>Bone marrow is the main site of neutrophil differentiation, maturation and storage. Neutrophils, innate immune cells with a rich arsenal of anti-bacterial functions, traffic to the brain in large numbers following ischemic stroke. Age has previously been reported to impair …
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Neutrophil Responses to Mixed-Species Anaerobic Biofilms
… necrophorum and Porphyromonas levii and measure neutrophil responses. Neutrophils are a vital component of the innate immune system and the results show that neutrophils exposed to mixed-species planktonic bacteria exhibit a more extensive oxidative response than neutrophils exposed to biofilms …
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Neutrophil localization during C. rodentium-induced colitis
… in this project to understand the activity of neutrophils, often the first cell line of defense, during infection. While it is known that neutrophils are involved in the eradication of C. rodentium, their presence during different phases of C. rodentium infection and functions at these time …
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An in vitro study of neutrophil chemotaxis
When, at the beginning of 1972, my scientific attention was first drawn to the subject of cellular participation in the inflanunatory response, I was struck by the need for an understanding of the cellular and molecular mechanisms whereby blood leucocytes are attracted to an area of injury. The …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… initiation of autoimmune reactions. One form of neutrophil cell death deserves attention because it occurs as a consequence of neutrophil activation, requires the post-translational modification of histones and results in the extracellular release of chromatin. The extracellular chromatin …
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Mechanisms of neutrophil recruitment in septic lung injury
… intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. The aim of thesis was to prevent excessive neutrophil …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
Neutrophils adopt a highly polarized morphology and integrate many matrix-specific signals to undergo specialized migratory events to pursue invading pathogens. While these matrix-specific signaling events have emerged as crucial elements for proper migration and recruitment of neutrophil cells, …
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