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Showing 1 to 20 of 38 for “"neutron capture therapy"”.
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Computer simulation of neutron capture therapy.
… computer the production and use of reactor neutron beams f or boron capture therapy of brain tumors. The simulation accounts for radiation dose distributions in tissue produced by fast neutrons and by neutron capture reaction products such as gamma rays, C -particles, protons, and heavy …
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Accelerator-based boron neutron capture therapy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1997.
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Boron neutron capture therapy treatment planning improvements
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations …
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Hypoxia-selective compounds for boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal …
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Computational aspects of treatment planning for neutron capture therapy
Boron Neutron Capture Therapy (BNCT) is a biochemically targeted form of binary radiation therapy that has the potential to deliver radiation to cancers with cellular dose selectivity. Accurate and efficient treatment planning calculations are essential to maximizing the efficacy of BNCT and …
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High-power target development for accelerator-based neutron capture therapy
… sufficient dose rates in Accelerator-based Neutron Capture Therapies (ABNCT) requires targets that can withstand ion beams of 2-10 kW or higher. Designing such a target requires knowledge of the current density profile which can exceed 1 mA/cm². A method has been developed to quantify the …
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
Boron Neutron Capture Therapy (BNCT) is a binary cancer radiation therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal …
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Microdosimetric studies for neutron capture therapy and techniques for capture element selection
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1995.
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Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy
… (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and boronophenylalanine (BPA). In vitro evaluations utilized a colorimetric assay and 96-well plates to …
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Engineering design of a fission converter-based epithermal beam for neutron capture therapy
… high intensity and low contamination epithermal neutron beams, for boron neutron capture therapy research and for routine treatment if this becomes a successful modality for treating cancers. A fission converter based design for high performance epithermal neutron beam was developed at the …
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Medical room design for a fission converter-based boron neutron capture therapy facility
… of a shielded medical room to be used in Boron Neutron Capture Therapy was developed. The design included analytical shielding calculations, computational methods using the Monte Carlo N-particle transport code, and experimental measurements using the current medical room. The design included …
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Neutron dosimetry, moderated energy spectrum, and neutron capture therapy for ²⁵{45}R²Cf medical sources
Examination of neutron dosimetry for 252Cf has been conducted using calculative and experimental means. Monte Carlo N-ParticIe (MCNP) transport code was used in a distributed computing environment as a parallel virtual machine (PVM) to determine the absorbed neutron dose and neutron energy spectrum …
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Lithium-6 filter for a fission converter-based Boron Neutron Capture Therapy irradiation facility beam
… method was used to measure the photon, thermal neutron and fast neutron dose. The measured advantage depth is 9.3 ± 0.1cm without filter and 9.9 ± 0.1cm with 8mm lithium-6 filter. The result is consistent with the result of Monte Carlo calculation.
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Beam characterization for accelerator-based boron neutron capture therapy using the ⁹Be(d,n) nuclear reaction
… nuclear reaction for accelerator-based boron neutron capture therapies (AB-BNCT) was investigated. The moderated neutron spectra produced at several deuteron bombarding energies were evaluated in terms of dose rates and dosimetric profiles in a water-filled brain phantom using an existing …
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Safety analysis report and technical specifications of the MITR fission converter facility for neutron capture therapy
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1997.
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High Resolution Quantitative Auto-Radiography to determine microscopic distributions of B-10 in neutron capture therapy
The success of Boron Neutron Capture Therapy (BNCT) is heavily dependent on the microscopic distribution of B-10 in tissue. High Resolution Quantitative Auto-Radiography (HRQAR) is a potentially valuable analytical tool due to its ability to simultaneously visualize boron distributions and tissue …
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The Final Computational and Experimental Performance Characterization of the Washington State University Neutron Capture Therapy Facility Neutron Beam
Made available in DSpace on 2017-07-06T18:58:50Z (GMT). No. of bitstreams: 3 Sloan_Patrick_E_MS.pdf: 1273678 bytes, checksum: 95f2d08e5eb9d3a8f60f64d5de4a9287 (MD5) Sloan_Patrick_E_MS_ABS.pdf: 10663 bytes, checksum: 87674aed7fac77777dd5b15c9f3af7fd (MD5) license.txt: 4813 bytes, checksum: …
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Sensitivity studies of the neutronic design of a fission converter-based ephithermal beam for boron neutron capture therapy
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1997.
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