Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"neutralization escape"”.
-
Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
… in early infection, and the impact of humoral escape on viral fitness. It remains an open question whether different geographically distinct population groups vary in their neutralization responses to HIV-1. We compared neutralizing antibody responses in two African cohorts and found 35% of the …
-
Virus tropism and neutralization response in SIV infection
… response was accompanied by early appearance of neutralization resistant variants. The majority of monkeys with progressive disease showed broadening of coreceptor use, stable coreceptor use or fluctuation in the use of different coreceptors. Viruses maintained effective replication in …
-
Effects of variation in N-linked glycosylation site on antibody mediated neutralization in PRRSV
… this immune response is to have mutants that can escape the neutralization antibody response. Various studies have been done to indicate that the envelope glycoprotein 5 bears a major neutralizing epitope. The ectodomain of glycoprotein 5 in PRRSV has a neutralization epitope which is flanked by …
-
Development, Characterization, and Use of Molecular Tools to Study Immune-Driven Zika Virus Evolution
… and mosquito models and their sensitivity to neutralization. We observed that while both E-V355I and NS1-T139A have increased fitness in mammalian cells, they had reduced fitness in mosquitoes. These results align with the trade-off hypothesis, which states that in a multi-host system, …
-
Structure-function of Dengue 2 virus envelope protein domain III with neutralizing antibodies
… (E) protein is the primary target. Potency of neutralization has been correlated with the particular domain on the E protein recognized by a neutralizing antibody, with domain III of the E protein (ED3) being the target of the most potent neutralizing antibodies. The objective of this …