Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 99 for “"neutralisation"”.
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Rhinovirus neutralisation and the role of TRIM21
To be added
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Modelling the neutralisation process in neutral beam injectors
… failure to achieve near maximum theoretical neutralisation efficiency, has given motivation to those concerned to endeavour to understand the reason thereof. This neutralisation efficiency deficit is almost certainly due to gas target depletion, while the general consensus is that indirect …
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Enzyme and Directed Evolution Technologies For Nerve Agent Neutralisation
Owing to the magnitude of the utilisation of organophosphorus (OPs) insecticides and the possibility of using OPs nerve agents (NA) against civilian populations, the research and development of enzymes involved in the biotransformation and detoxification of OPs has attracted considerable attention …
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The Neutralisation of acid mine drainage by fly ash
… due to the lower Cao concentration. Batch neutralisation experiments were conducted with a series of fly ash: AMO ratios, ii and equilibrated on a reciprocating shaker for 72 hours. The results showed that the r------~----·---··· higher lime concentration of the Arnot fly ash results in a …
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Active neutralisation and amelioration of acid mine drainage with fly ash
… fly ash could be successfully applied for the neutralisation of acid mine drainage (AMD) and effectively attenuate the sulphate load in the treated water. The critical parameters to this technology are the variations of chemical composition and mineralogy of fly ash, which could influence the …
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The role of virus neutralisation in immunity to feline immunodeficiency virus infection
… this project a robust and reproducible in vitro neutralisation assay was developed and optimised, permitting the assessment of the NAb response in naturally infected cats and with the potential to evaluate candidate vaccines. It was demonstrated that, in general, primary FIV strains in the UK …
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Characterisation of functional properties of Envelopes of highly neutralisation resistant HIV-1 isolates
… important to study and better understand highly neutralisation resistant viruses. To this effect, we characterized sets of subtype C and CRF02_AG viruses whose neutralisation phenotype were well defined using within subtype neutralisation (neutralisation by subtype matched sera). Our main aim was …
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
Antibody dependent intracellular neutralisation (ADIN) mediates the rapid proteasomal degradation of antibody-bound viruses. It requires TRIM21, an Fc receptor and E3 ubiquitin ligase that resides in the cytosol. Binding of TRIM21 to the exposed Fc portion of an antibody that is bound to an …
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Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses
… the mechanisms used by HIV-1 to evade antibody neutralisation may contribute to the design of a high-coverage vaccine. This thesis explores the mechanism used by a Tier 3 virus leading to its high antibody neutralisation resistance phenotype. This thesis also describes how the glycans at the …
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Justifications for the Implementation of Shadow IT Solutions by Functional Departments in an Organisation
… approach. The study was guided by the 'Neutralisation Theory’ from the social deviance discipline. The study examined whether an organisation had an IT policy which prevents end-users from implementing SIT, and also assessed the 'Neutralisation’ techniques employed by end-users to …
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High quality high current ion beam generation and transport systems including plasma-based space charge neutraliser
… the desired plasma conditions.3. Space charge neutralisation: Space charge neutralisation is essential to transport high perveance beams because a beam without neutralisation develops a high electric potential in itself that would scatter beam ions away. A plasma based charge neutraliser …
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Characterisation and improvement of the rehydration behaviour of high-protein milk powder
… of MPI was studied in a different sequence of neutralisation. Our results showed that as the porous structure modified the gas distribution in agglomerated MPI, interstitial air within agglomerates and vacuole air within agglomerates determined the gas release behaviour of agglomerated powder, …
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Separation and purification of mucins and tenascin-C in breast milk of patients and the investigation of the role of mucins and tenascin-C in the inhibition of HIV-1
… was tested in this assay showing strong HIV-1 neutralisation. Pasteurisation (80°C for 10 minutes) of both HIV positive and negative breast milk indicated good neutralisation of HIV-1 in our laboratory. Another breast milk protein, tenascin-C (TNC), was recently shown to strongly neutralise …
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Un répertoire du vocabulaire oral des enfants francophones de 6 à 12 ans au Québec
… dans notre corpus, il faut chercher une neutralisation des différences individuelles ou thématiques». En effet, pour être valable, un essai de listing du vocabulaire oral doit tenir compte de nombreux paramètres, tels que: -la langue spécifiquement orale; -la dispersion géographique des …
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Generation and characterization of HIV-1 subtype C candidate vaccines that will induce high titre antibody responses to HIV-1 envelope glycoprotein
… which resulted in robust autologous Tier 2 neutralisation of CAP256_SU pseudovirions. The envelope glycoprotein sequence was modified so as to replace the native leader sequence with the tissue plasminogen activator leader, the furin cleavage site with a glycine rich flexible linker, and to …
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Neutralising antibody responses in acute hepatitis C and SARS-CoV-2 infection
… clearers were also more susceptible to neutralisation compared to chronic progressors. The second part of this thesis describes how the techniques utilised to study nAb responses in HCV were adapted to study Severe acute respiratory syndrome (SARS) coronavirus (CoV) -2, hoping to unravel …
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Justifications for re-sharing non-consensual pornography on social media platforms: A case of South Africa
… understand how these justifications are used as neutralisations to continue to perpetuate this behaviour. Research Design/Methodology: This study employed a qualitative approach, which is interpretive. Primary data was collected using semi-structured interviews, and the participants were provided …
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HPV pseudovirion production in plants
… of a robust and sensitive pseudovirion-based neutralisation assay (PBNA), which has become the gold standard neutralisation assay for the testing of candidate HPV vaccines. The currently accepted PsV production method utilises mammalian cell culture to produce HPV PsVs, encapsidating a SEAP …
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Evaluating the effect of alternative neutralising agent and seeding on the zinc recovery through the Zincor iron removal circuit
… much room for improvement. The calcine used for neutralisation in the Iron Removal Stage contained a portion of insoluble zinc ferrite. The insoluble zinc loss through the iron residue was associated with the presence of the insoluble zinc ferrite, as well as the phenomenon of coating of …
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