Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"neurovirulence"”.
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UNDERSTANDING THE NEUROVIRULENCE OF ENTEROVIRUS 71
NITD008, an adenosine nucleoside analog, was shown to fully protect EV71-infected two-week old AG129 mice from morbidity and mortality. NSC-34, a murine motor neuron cell line, was found to be susceptible and permissive to EV71 infection, with S41 strain being the most infectious in NSC-34 cells …
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The pathogenesis of murine retroviral-induced noninflammatory spongiform polioencephalomyelopathy: Neuronal degeneration is indirectly mediated by resident microglial cells
… To determine the biologic basis of ts1 MoMuLV neurovirulence, newborn CFW/D mice were inoculated with neurovirulent ts1 MoMuLV, non-neurovirulent wt MoMuLV, or conditioned media from control cell cultures, and the temporal response to virus infection in the CNS, spleen, and thymus studied …
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Autophagy in Antiviral Immunity
… pathway. We found that the HSV-1 encoded neurovirulence protein ICP34.5 interacted with the host autophagy protein Beclin 1, and that this interaction was essential for HSV-1 neurovirulence. This was the first example of a viral virulence protein that targets host autophagy, and provided …
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Characterizing the Cellular Response to Astrovirus Infection in the Central Nervous System
… insights into the mechanisms of AstV-induced neurovirulence, essential for developing therapeutic strategies to manage AstV-associated CNS diseases.</p>
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… of E glycosylation did not significantly affect neurovirulence. Mice immunized with the E mutant virus developed a robust neutralizing antibody response and were completely protected from wild-type ZIKV challenge. In mosquitoes, the mutant virus exhibited diminished oral infectivity for the Aedes …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… of E glycosylation did not significantly affect neurovirulence. Mice immunized with the E mutant virus developed a robust neutralizing antibody response and were completely protected from wild-type ZIKV challenge. In mosquitoes, the mutant virus exhibited diminished oral infectivity for the Aedes …
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Population Structure of Yellow Fever Virus: Influence of Viral Diversity on Vaccine Attenuation
… concurrently to 17D. FNV strains with high neurovirulence contained homogeneity in their population structures, showing that the neurotropic adverse events caused by FNV were the result of mouse brain adaptation to attenuate. A deep sequencing study of an adapted strain of Asibi which causes …
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Cell tropism of maedi-visna virus
… this extended cell tropism is associated with neurovirulence. LTR is the virus promoter region and contains enhancer sequences that cellular transcription factors can bind to. It is therefore likely that this difference between the two virus strains is because of transcription regulation. The …
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The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
… damage. Mechanistic analyses identify the viral neurovirulence factor ICP34.5 as a key driver of this process through the JNK-EGR-1-HPSE axis, leading to glycocalyx remodeling and enhanced viral spread. Importantly, pharmacological inhibition of JNK signaling significantly reduces SDC1 shedding, …
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DENVax live attenuated chimeric dengue vaccine
… peak titers, efficiency of replication, and neurovirulence, showed that the ehimeric viruses for each serotype were attenuated in comparison to the wild type parental viruses. Tetravalent formulations with the chimeric D2/1, D2/3 and D2/4 viruses as well as the D2-PDK53 virus were tested for …
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Die Bedeutung von Mutationen im Hämagglutinin des Masernvirus für Neurovirulenz und Antikörpererkennung
Masernvirus (MV) ist ein negativ-strängiges RNA-Virus, das im Menschen und im Nagermodell zu akuten und subakuten Enzephalitiden führen kann. Es wurde beschrieben, dass bestimmte Antikörperescape-Mutanten des MV neurovirulent, andere nicht neurovirulent sind (Liebert et al., 1994). Mit Hilfe von …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
Cache Valley virus (CVV) is an emerging mosquito-borne orthobunyavirus of significant concern to One Health. CVV was first isolated from Culiseta inornata mosquitoes in Cache Valley, Utah in 1956 and has sporadically emerged to cause epizootics in livestock, particularly affecting small ruminants. …