Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"neurovascular unit"”.
-
The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… the functional and structural integrity of the neurovascular unit (NVU). <br/><br/><b>Methods.</b> <i>Experimental Study 1: </i>In a randomised, single-blind cross-over design, 12 healthy, physically active male participants (age, 23 ± 2 yrs; BMI, 25 ± 4 kg/m<sup>2</sup>) were exposed to 6 hours …
-
Development and characterisation of a human in vitro model of the Neurovascular Unit using a biomimetic tissue engineered system
The neurovascular unit (NVU) is a complex structure comprising endothelial cells, pericytes, astrocytes, neurons, and extracellular matrix (ECM) elements. It plays an essential role in regulating cerebral blood flow and maintaining the integrity of the blood-brain barrier (BBB). Over the years, …
-
Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… the circulatory and central nervous systems, the neurovascular unit is vital to the development and survival of tumors. The malignant brain cancer glioblastoma multiforme (GBM) displays invasive growth behaviors that are major impediments to surgical resection and targeted therapies. Adhesion and …
-
The Effect of Chronic Hypertension on Neuropathology in the TGSWDI Mouse Model of Alzheimer's Disease
… structures altered cellular morphology at the neurovascular unit and compromised the blood brain barrier in hypertensive mice. Additionally, midlife hypertension induced hippocampal neurodegeneration at an early age in TgSwDI mice. Neuronal loss is a defining characteristic of pathology in …
-
Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… to widespread defects in homeostasis of the neurovascular unit, including increased intracerebral blood vessels with enhanced perivascular astrogliosis. Additionally, β8 integrin dependent defects in NSC proliferation, survival, and differentiation, as well as neuroblast migration in the RMS …
-
Understanding The Role Of Transforming Growth Factor-β Activated Kinase-1 During Inflammation in Diabetic Retinopathy
… understood but is known to affect the health of neurovascular units through the activation of inflammatory factors and cytokines. Loss in barrier activity in the neurovascular unit leads to leukocyte infiltration leading to the activation of microglia. The role of TAK1 was investigated in murine …
-
Investigating peripheral inflammation induced neuroinflammation in the absence of blood-brain barrier breakdown in relation to Alzheimer’s disease
… inflammatory signals can propagate to the neurovascular unit (NVU), an in vitro BBB model was developed using brain endothelial cells, pericytes, and astrocytes cultured above a secondary compartment containing astrocytes, neurons, and microglia. An acute peripheral inflammatory stimulus …
-
Vertex-Based Analysis of Cerebral Blood Flow and Fractional Amplitude of Low-Frequency Fluctuations (CBF-fALFF) Coupling in Moderate-to-Severe Traumatic Brain Injury During the First Year Post-Injury
… injury (TBI) is known to involve damage in the neurovascular unit. TBI may disrupt the brain’s neurovascular coupling–the relationship between cerebral blood flow and neural activity–that can lead to cognitive and functional impairments. This study attempted to non-invasively investigate …
-
Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
… The blood-spinal cord barrier (BSCB), a neurovascular unit that limits passage of most agents from systemic circulation to the central nervous system, breaks down, resulting in inflammation, scar formation, and other sequelae. Protracted BSCB disruption may exacerbate cellular injury and …
-
Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
… vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, which is significantly impacted by the diabetic milieu. It has now been established that the endothelium relies on glycolytic metabolism predominantly for ATP generation, however the degree of flux …
-
Modeling Post Stroke Respiratory Dysfunction, Apneas and Cognitive Decline
… pathophysiology of SIRD and provide the opportunity to test potential pharmacological agents.</p> <p>We developed and characterized an animal model of stroke induced respiratory dysfunction recapitulating the respiratory phenotype witnessed in the clinical population, characterized by …
-
Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
… cells, astrocytes, and neurons, comprise the neurovascular unit. Brain pericytes are required for neurovascular regulation, and BBB integrity. Pericyte dysfunction is also an early pathology associated with diabetic retinopathy indicating these cells are exposed to systemic conditions. For the …
-
The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
P-glycoprotein (P-gp; encoded by Abcb1) at the blood-brain barrier (BBB) plays an important role in regulating the movement of exogenous and endogenous substrates into the developing brain. P-gp levels in brain endothelial cells (BECs), which form the capillaries of the BBB, increase dramatically …
-
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… area, the physiology and pathophysiology of the neurovascular unit, the complex network of endothelial cells, smooth muscle cells, inflammatory cells and mediators are not fully understood, which is necessary in order to develop effective therapies. The aim of the present thesis was to examine …