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Showing 1 to 12 of 12 for “"neurotrophin-3"”.
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Functional recovery in young adult and aged rats following delayed, intramuscular treatment with neurotrophin-3 after focal stroke injury.
… in adult and aged rats following treatment with neurotrophin-3 (NTS). Endothelin-1 produces a reduction in local blood flow to levels that produce ischemic injury when applied to areas of the brain. Due to the reproducible nature and location of this injury, we can qualitatively and …
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Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
… by the inhibitor BMS-453 and have identified neurotrophin-3 (NT-3), activated leukocyte cell adhesion molecule (ALCAM) and Semaphorin 4B (Sema4B). We have analyzed the expression patterns of Sema4B and NT-3 by in situ hybridization and have found NT-3 expression in the eye and Sema4B in the …
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Der Einfluss von neurotrophen Faktoren auf das biologische Verhalten von Medulloblastomen
… Faktoren untersucht. Diese verwendeten Neurotrophine wirken innerhalb der untersuchten Medulloblastom-Zellinien und –Primärkulturen in unterschiedlicher Weise auf Proliferation, Migration und das Invasionsverhalten der Tumorzellen. Dies geschieht in Abhängigkeit der exprimierten …
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Charakterisierung der Auswirkungen einer pathogenen Mutation im Neurotrophinrezeptorgen trkA im Zellkulturmodell
… the exact timing and location of the action of neurotrophins and their receptors plays an important role. They support survival and differentiation of neuronal cells. The prototypic neurotrophin NGF (nerve growth factor) specifically stimulates the transmembrane receptor TrkA. The TrkA Isoform …
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Calcium signalling in the nervous system
… GDNF, vascular endothelial growth factor (VEGF), neurotrophin - 3 (NT - 3) and nerve growth factor (NGF)) could lead to an increased internal Ca2+ concentration due to the continuous stimulation of the PLC dependent signalling pathway(s). I investigated if long - term elevated Ca2+ concentration …
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Development of Combinatorial Strategies Employing Neural Stem Cells and Polymer Scaffold for Spinal Cord Repair
… therapeutic efficacy by ectopic expression of neurotrophin-3 (NT-3) in the hNSCs. NT-3 overexpressing hNSCs (NT3.F3) were produced by retroviral transduction of the immortalized hNSC line (F3) with human NT-3 cDNA. NT3.F3 cells were seeded into a predesigned PLGA (65:35) scaffolds, and the PLGA …
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Early Effects of Organophosphate Compounds on In Vitro Intracellular Signaling and Levels of Active Neurotrophin Receptors, and on In Vivo Neurotrophin Concentrations
… investigated the changes in levels of neurotrophins in vivo and how in vitro levels of neurotrophin receptors and their downstream signaling cascades are affected after exposure to OP compounds. We also characterized the molecular weight of a soluble factor responsible for inducing …
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Developing High Purity Embryonic Stem Cell-Derived V2a Interneurons for In Vitro Investigation and Transplantation Following Spinal Cord Injury
… brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and platelet-derived neurotrophic factor (PDGF) and/or by co-culture with ESC-derived progenitor motor neurons (ESC-pMNs). Although ESC-V2as did not variably respond to the growth factors applied when cultured in isolation, …
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Sustained Release of Growth Factors from Hyaluronic Acid Hydrogels and Polyethylene-Glycol Microparticles for Axonal Growth
… is one of the main causes of functional loss. Neurotrophin-3 (NT-3) and insulin-like growth factor-1 (IGF-1) are two growth factors that have been shown to improve axonal growth and functional recovery in several studies, but there is a lack of effective delivery methods capable of maintaining …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the brain, using enzyme-linked immunosorbent assay (ELISA). The neurological function assessed by rotarod motor test and modified …
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TrkB and gene expression
The neurotrophins are a family of secreted proteins that potently regulate diverse neuronal responses. Family members include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin 4/5(NT4/5). Neurotrophins bind the Trks receptor family (TrkA, B, …
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Molecular and Functional Characterization of TrkC Alternative Splicing Regulation and its Impact on the Fate Acquisition of Cortical Projection Neurons
… The focus of this work are two isoforms of the neurotrophin-3 receptor, TrkC, which result from alternative splicing. The better studied of the two isoforms, the kinase-active TrkC-TK+, has been shown to act as a recipient of survival signals in neurons. Our reseach group previously showed that …