Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"neurotrophin"”.
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Early Effects of Organophosphate Compounds on In Vitro Intracellular Signaling and Levels of Active Neurotrophin Receptors, and on In Vivo Neurotrophin Concentrations
… investigated the changes in levels of neurotrophins in vivo and how in vitro levels of neurotrophin receptors and their downstream signaling cascades are affected after exposure to OP compounds. We also characterized the molecular weight of a soluble factor responsible for inducing …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
Neurotrophins regulate sensory neuron survival, differentiation and phenotype, yet much remains to be discovered. The role of neurotrophins and neurotrophin receptors in adult primary sensory neurons was investigated along three main avenues 'in vivo'. First, to better predict neurotrophin …
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UNDERSTANDING THE INFLUENCE OF TDP-43 LOSS-OF-FUNCTION ON NEUROTROPHIN SIGNALLING
… Sortilin functions as a trafficking receptor for neurotrophins and a co-receptor in pro-neurotrophin mediated death, and its soluble form results in reduced activity-dependent secretion of BDNF, and potentiation of pro-neurotrophin related neurodegeneration. Mice with hippocampal depletion of …
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Voluntary Exercise and Neurotrophin Signaling Affect the Development and Presentation of Painful Neuropathy
… of DN, to investigate how diabetes alters neurotrophins and to determine if voluntary exercise is capable of reducing PDN. Initial studies used a model of obese, type 2 diabetes and investigated if voluntary exercise could reverse PDN. Diabetes resulted in mechanical allodynia, yet because …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and pro-nerve growth factor/p75 neurotrophin …
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The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
… wird eine entscheidende Rolle des niedrigaffinen Neurotrophinrezeptors p75NTR in Bezug auf axonale Schädigung in der experimentellen autoimmunen Encephalitomyelitis (EAE) gezeigt. Nach EAE Induktion per aktiver Immunisierung mit dem Myelin-Oligodendrozyten-Glykoprotein-Peptid MOG35-55 zeigten …
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Strategies for Neuroprotection Using Passive (Neurotrophin-Deprivation) and Active (Virotoxin Exposure) Models of Neuronal Cell Death
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2004.
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
Growth differentiation factor-5 (GDF-5) is a member of the transforming growth factor-β superfamily, a family of proteins that play diverse roles in many aspects of cell growth, proliferation and differentiation. GDF-5 has also been shown to be a trophic factor for embryonic midbrain dopaminergic …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
Neurotrophins are neuromodulatory proteins utilised within neuronal networks for development and survival. Based on previous evidence revealing the expression of neurotrophin components in immune cells, the present study investigates neurotrophin component expression within Burkitt’s Lymphoma B …
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Functional recovery in young adult and aged rats following delayed, intramuscular treatment with neurotrophin-3 after focal stroke injury.
… in adult and aged rats following treatment with neurotrophin-3 (NTS). Endothelin-1 produces a reduction in local blood flow to levels that produce ischemic injury when applied to areas of the brain. Due to the reproducible nature and location of this injury, we can qualitatively and …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
The p75 neurotrophin receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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Die Konzentrationen von Brain-Derived-Neurotrophic-Factor (BDNF) und Neurotrophin (NT 3) in humanem Hirngewebe bei der Demenz vom Alzheimer-Typ und Psychosen aus dem schizophrenen Formenkreis
… Verteilung und Funktionsweise beider Neurotrophine im ZNS, v.a. im zerebralen Cortex. Dies wird durch weitere Befunde der Literatur gestützt (Narisawa-Saito et al., 1996) sowie durch unsere Befunde bei der DAT und während des natürlichen Alterungsprozesses bestätigt. In unserer Arbeit …
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
… NGF action is achieved by binding two distinct Neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… factors, such as neurotrophic factors. The neurotrophin brain-derived neurotrophin factor (BDNF) has been shown to play an important role in proliferation and differentiation of cortical neuronal precursors (Bartkowska et al 2007). Moreover, BDNF induces binding of the transcription factor …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… of test compounds in a single assay. The neurotrophin signaling pathways were interrogated with selective inhibitors of MEK1/2 (PD98059/U0126) PI3K (LY294002) and TrkA (GW441756) and phosphorylation of target kinases. Associated factors namely, acetylation of histones (H3/H4) and …
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Der Einfluss von neurotrophen Faktoren auf das biologische Verhalten von Medulloblastomen
… Faktoren untersucht. Diese verwendeten Neurotrophine wirken innerhalb der untersuchten Medulloblastom-Zellinien und –Primärkulturen in unterschiedlicher Weise auf Proliferation, Migration und das Invasionsverhalten der Tumorzellen. Dies geschieht in Abhängigkeit der exprimierten …
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Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb
… by regulatory and compensatory changes in the neurotrophin NGF and its receptors.
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