Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 165 for “"neurotrophic factor"”.
-
Ciliary neurotrophic factor (CNTF) im olfaktorischen System von Ratten und Mäusen
… zeigte, dass die Axone CNTF-ir ON in Glomeruli olfactorii projizierten, die bilateralsymmetrisch in beiden BO eines Tieres lokalisiert waren. Diese Symmetrie findet man ebenfalls bei den Projektionen der ON, die das gleiche olfaktorische Rezeptorprotein exprimieren. Die Lokalisation der CNTF-ir …
-
Regulation of Brain-Derived Neurotrophic Factor in the Adult Mouse Brain
… adult central nervous system (CNS) brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection and synaptic plasticity among other functions. However, relatively little is known of its regulation. In this thesis, we attempted to learn more about BDNF regulation by means of: an …
-
Expression und Funktion von Brain-derived-neurotrophic-factor in humanen Podozyten
Der derzeitige Kenntnisstand betreffend des neuronalen Wachstumsfaktors BDNF beruht überwiegend auf neurobiologischen Untersuchungen. Daher bleibt die mögliche Bedeutung einer in jüngster Zeit beobachteten BDNF-Expression auch in nicht-neuronalen Geweben zukünftig weiter abzuklären. <br> <br>In …
-
Effect of low endogenous brain-derived neurotrophic factor levels on striatal dopamine dynamics
… disorder (ADHD), and depression is brain-derived neurotrophic factor (BDNF). As a trophic factor, BDNF role is to assist in the growth, survival, and differentiation of neurons. However, there is increasing evidence that BDNF may mediate neurotransmitter dynamics. Our goals were to understand how …
-
The glial cell line-derived neurotrophic factor family in the olfactory system and brain
Glial cell line-derived neurotrophic factor (GDNF) family signaling has been implicated in development, survival and function of many different cell types, including neurons in the central nervous system. The family consists of four ligands [GDNF, neurturin (NTN), artemin and persephin] which bind …
-
Regulation of brain-derived neurotrophic factor in the neuroendocrine melanotrope cell of Xenopus laevis
Contains fulltext : 147013.pdf (Publisher’s version ) (Open Access)
-
Brain derived neurotrophic factor and structural vascular disease in black Africans : the SABPA study
Motivation - Brain-derived neurotrophic factor (BDNF) is a protein complex, synthesised and secreted mainly by the central nervous system and is involved in neuronal maintenance. Research suggests that BDNF is implicated in various neurological and psychiatric diseases, while recent evidence …
-
Identification and characterization of a novel neurotrophic factor secreted by a mouse Schwann cell line
During development, neurotrophic factors regulate morphologic and functional differentiation in addition to their role as regulators of neuronal survival. Schwann cells are the major glial elements in the peripheral nervous system and, therefore, could play a major functional role in supporting …
-
Cloning of medaka glial cell-derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
Glial cell line-derived neurotrophic factor (GDNF) signaling through its receptor GFRI?1 plays an important role in many biological processes including cell survival, proliferation and differentiation. The aim of this project was to isolate and characterize both Gdnf and GfrI?1 from the medaka fish …
-
Ciliary neurotrophic factor signaling in the magnocellular neurosecretory system : mechanisms of neuronal survival and sprouting
<p>While it is well-known that ciliary neurotrophic factor (CNTF) promotes the survival of a myriad of neuronal phenotypes, little is understood on the specific CNTF-induced neuroprotective mechanisms in the central nervous system (CNS). Elucidation of these mechanisms may provide insight that …
-
THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
<p>Brain-derived neurotrophic factor (BDNF) is a neurotrophin required for the differentiation, growth, and survival of neurons. BDNF is synthesized in several tissue types including skeletal muscle. Neuromuscular diseases (NMDs) are characterized by the degeneration of motorneurons and/or …
-
Neuroprotektive Funktion des Ciliary Neurotrophic Factor : Untersuchungen an CNTF-defizienten Mäusen nach Läsion der septohippokampalen Projektion
Die exogene Zufuhr neurotropher Proteine, wie CNTF und LIF, kann zentrale Neurone vor läsionsinduzierten degenerativen Veränderungen bewahren. Bislang war jedoch ungeklärt, ob dies die physiologische Funktion der endogenen Neurotrophine/Zytokine widerspiegelt, oder ob es sich um eine …
-
Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
… involved in such mechanisms is brain-derived neurotrophic factor (BDNF). Aberrant regulation of BDNF has been implicated in the development of psychiatric disorders, including schizophrenia, depression, anxiety and alcohol addiction (Moonat et al., 2010). Multiple actions of ethanol on BDNF …
-
Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.
… be mediated through regulation of brain-derived neurotrophic factor (BDNF). Recently, lithium ion has been shown to selectively protect spinal motor neurons in animal models of amyotrophic lateral sclerosis (ALS) by preventing the apoptosis component. In this study, investigation was undertaken …
-
THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS
… pathology may be a reduction in brain-derived neurotrophic-factor (BDNF) signaling at the motor unit. We have shown that mice deficient in skeletal muscle-synthesized BDNF (msBDNF) demonstrate progressive motorneuron and muscle pathology at 120d. We hypothesize mitochondrial populations will be …
-
Influence of Brain Derived Neurotrophic Factor and Family History of Alcohol Dependence on Alcohol Use in Healthy Social Drinkers
Brain-derived neurotrophic factor (BDNF) is important for neuronal survival, differentiation and consolidation of synaptic strength. Studies have found increased alcohol use and genetic risk for alcohol dependence in individuals with the Val66Met single-nucleotide polymorphism (SNP) of the BDNF …
-
Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… of the neurotrophin glial cell line-derived neurotrophic factor (GDNF) has been implicated in promoting postnatal regenerative processes in the ENS. It has been proposed that intestinal smooth muscle cells (ISMC) express GDNF as a precursor molecule that requires proteolytic processing to …
Page 1 of 9