Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"neurotrauma"”.
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Experimentelles Neurotrauma im Mausmodell
Auch milde Traumata des Schädels können beim Menschen persistierende und klinisch relevante Beschwerden verursachen. Die vorliegende Arbeit stellt in einem Modell des Schädel-Hirn-Traumas der Maus die läsionsspezifischen Charakteristika auf verhaltensbiologischer und morphologischer Ebene dar und …
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Epigenetic Mechanisms in Blast-Induced Neurotrauma
Blast-induced neurotrauma (BINT) is a prevalent brain injury within both military and civilian populations due to current engagement in overseas conflict and ongoing terrorist events worldwide. In the early 2000s, 78% of injuries were attributable to an explosive mechanism during overseas …
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Management of Neurotrauma in Low-Resource Settings
… (TBI) - also referred to throughout the text as neurotrauma - a history of clinical practice guidelines, the Brain Trauma Foundation guidelines for the treatment of severe TBI (sTBI), the paucity of clinical trials carried out in low- and middle-income countries (LMICs) that make the development …
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Impaired Behavioral and Pathological Outcomes Following Blast Neurotrauma
Blast-induced neurotrauma (BINT) is a major societal concern due to the complex expression of neuropathological disorders after exposure to blast. Disruptions in neuronal function, proximal in time to the blast exposure, may eventually contribute to the late emergence of the clinical deficits. …
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Antioxidant Biomarkers and Nutraceutical Therapeutics in Neurodegeneration and Neurotrauma
<p>Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal …
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Transcranial Administration of Nano Pulse Laser Therapy for Blast Induced Neurotrauma
Treatment and care for mild traumatic brain injury (mTBI) is often overlooked in TBI research, yet it is the most common form of TBI. Moderate-severe TBI is accompanied by distinct behavioral and physiological characterizations, while mTBI presents variably. mTBI is a promising target for …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
Traumatic brain injury (TBI) is a major medical concern that has demonstrated to be particularly challenging to treat because of the disparity amongst injury modes and severities. Increased use of explosive devices during combat has caused blast TBI (bTBI) to become a widespread consequence in …
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The Effects of Blast-Induced Neurotrauma on Blood-Brain Barrier Permeability, Cell-Cell Junction Protein Levels and the Role of Peroxynitrite
… researchers and clinicians alike. Blast-induced Neurotrauma (BINT), often caused by improvised explosive devices (IEDs), is an injury that affects military personnel, however, the increasing threat of worldwide terrorist attacks makes this a concern for all individuals. Many of those who are …
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The Rat as a Translational Model of Neurotrauma: Primary Somatosensory Input and Imaging Biomarker Validation Following Spinal Cord and Peripheral Nerve Injuries
Neurotrauma is a leading cause of death and disability worldwide. Trauma is inherently chaotic and difficult to study, necessitating the use of translational models that provide standardizable and quantifiable models of injury. Rats are the most commonly used models of spinal cord (SCI) and …
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Methods and algorithms for quantitative analysis of metallomic images to assess traumatic brain injury
… disease CTE and TBI, mouse models of blast neurotrauma (BNT) and impact neurotrauma (INT) are investigated. First, a high-speed video tracking algorithm is developed based on K-means clustering, active contours and Kalman filtering to comparatively study the head kinematics in blast and …
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Attributes of Astrocyte Response to Mechano-Stimulation by High-Rate Overpressure
Blast neurotrauma represents a significant mode of traumatic injury to the brain. The incidence of blast neurotrauma is particularly high amongst military combat personnel and can be debilitating and endure clinically for years after injury is sustained. Mechanically, blast represents a unique and …
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Experimental study of bubble rupture during shock-fluid interaction
… There are four distinct types of blast induced neurotrauma (BINT): 1) these caused by supersonic shock waves propagating in the atmosphere (primary), 2) high velocity impact of shrapnel and debris (secondary) 3) acceleration and deceleration of the body and collision with the solid objects in …
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Subconcussive blows in high school football : putting young brains at risk
… Talavage at Purdue University formed the Purdue Neurotrauma Group (PNG), and set out to study concussions in high school football. They set up a study that combined helmet sensors with fMRI brain scans and cognitive testing, hoping to figure out what happens when a player gets a concussion on the …
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The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… immune cells contribute to STING signaling after neurotrauma, and that loss of STING in either cell population is beneficial. Taken together, this work demonstrates that canonical, cGAS-dependent STING signaling occurs primarily in microglia and peripheral immune cells, resulting in detrimental …
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Decreasing Risk of Delirium with Early Progressive Mobility
… surgical intensive care unit and the other is a neurotrauma critical care unit. The methods for implementation included writing the management of pain, agitation, and delirium policy based upon the recommended bundle from the Society of Critical Care Medicine referred to as the ABCDE bundle. As …
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Clinical Applications of Neuromonitoring Following Acute Brain Injury
… and general intensive care patients. Thirty neurotrauma patients and forty general intensive care patients with neurological complications were prospectively monitored after ABI. Retrospective patient data was harvested from a database of 1,023 traumatic brain injury (TBI) patients with …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… and disease. Rodent models of blast induced neurotrauma (BINT) and severe osteoporosis were used to inform the development of 2D and 3D in-vitro models of macrophage/endothelial cell injury and osteogenic differentiation respectively. Keratin biomaterials exhibited some potential to alter …
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Characterization and therapeutic evaluation of a traumatic brain injury model in compliance with common data elements
… of a potentially therapeutic drug to treat neurotrauma. Olaparib (Lynparza®) is a Poly(ADP-polymerase) 1 (PARP1) inhibitor approved by the FDA for the treatment of breast and ovarian cancer. Several studies reported the activation of PARP1 after injury in the central nervous system. This …
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The Post Deployment Lived Experience of U.S. Military Troops after Combat-Related Blast Exposure
Blast-induced neurotrauma (BINT) is a newly emerging re-occurrence of an old combat-related injury in U.S. military troops returning from deployment in Afghanistan and Iraq. BINT is leading to a silent epidemic of symptomatic troops who face barriers to accessing healthcare and suffer debilitating …
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