Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"neurotransmitter release"”.
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Mechanism of Synaptotagmin Action in Neurotransmitter Release
Neurotransmitter release occurs by fusion of the synaptic vesicle membrane with the plasma membrane. Formation of a highly stable complex, known as the SNARE (soluble NSF-attachment protein receptors) complex, brings the two membranes close in space. SNARE complex formation is required but probably …
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Mechanism of Synaptotagmin Action in Neurotransmitter Release
Neurotransmitter release occurs by fusion of the synaptic vesicle membrane with the plasma membrane. Formation of a highly stable complex, known as the SNARE (soluble NSF-attachment protein receptors) complex, brings the two membranes close in space. SNARE complex formation is required but probably …
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Unraveling the Role of SNARE Interactions in Neurotransmitter Release
The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is tightly controlled by an intricate protein machinery. Essential components of this machinery are the synaptic vesicle protein synaptobrevin and the plasma membrane proteins syntaxin 1 and SNAP-25, which are …
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Insights into the Functions of Munc18-1 in Neurotransmitter Release
Neurotransmitter release is an exquisitely regulated process that transmits signals between neurons. The release process includes: docking of synaptic vesicles at the active zone of the pre-synaptic plasma membrane, priming to a release ready state, and then membrane fusion and release of …
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Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
Neurotransmitter release is a tightly regulated process that involves synaptic vesicle docking at presynaptic active zones, priming of the vesicles to a release-ready state, and calcium evoked fusion of the vesicle and plasma membranes. The probability of release is modulated by plastic changes …
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Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
Neurotransmitter release is a central event in interneuronal communication. The release machinery includes three SNAREs (soluble N-ethylmaleimide sensitive factor adaptor protein receptor) and Munc18-1 as core components. Munc13, synaptotagmin and complexin underlie the exquisitely tight regulation …
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Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
… werden, dass eine cAMP-bedingte Steigerung der Neurotransmitterfreisetzung sowohl auf eine Erhöhung der vesikulären Freisetzungswahrscheinlichkeit als auch auf eine Zunahme der Zahl freisetzbarer Vesikel zurückgeführt werden kann. In der vorliegenden Dissertation wurde die Beteilung des neuen …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
Protein-Protein Interactions That Regulate Neurotransmitter Release from Retinal Ribbon Synapses Photoreceptors and bipolar cells in the retina form specialized chemical synapses called ribbon synapses. This type of synapse differs physiologically from “conventional” chemical synapses. While …
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Dissection of the Roles of Synaptotagmins in Calcium Dependent Neurotransmitter Release
Neuronal communication is mediated by neurotransmitter release, which is triggered in response to a calcium influx into the presynaptic cell, caused by the arrival of an action potential. Synaptotagmins (Syts) mediate this calcium-dependent regulation of neurotransmitter release by mechanisms that …
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Structural and Functional Studies of C2-Domain Proteins Involved In Neurotransmitter Release
Neurotransmitter release is mediated by synaptic vesicle exocytosis at presynaptic nerve terminals. This process is extremely fast and strictly regulated by the intracellular Ca2+ concentration. To achieve this exquisite regulation, many proteins are involved. The central fusion machinery includes …
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A genetic analysis of complexin function in neurotransmitter release and synaptic plasticity
Information transfer at neuronal synapses requires rapid fusion of docked synaptic vesicles in response to calcium influx during action potentials. The molecular nature of the fusion clamp machinery that prevents exocytosis of synaptic vesicles in the absence of a calcium signal is still unclear. …
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Reevaluating the functional role of the C₂A domain of synaptotagmin in neurotransmitter release
… fusion of vesicles with the membrane, releasing neurotransmitter. The synaptic vesicle protein, synaptotagmin, was identified as the Ca2+ sensor for this fast, synchronous neurotransmitter release. It is hypothesized that Ca2+ binding by synaptotagmin acts as an electrostatic switch. At rest, …
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Calcium sensitivity of neurotransmitter release in a glutamatergic synapse of the central nervous system
Der Signalübertragung an chemischen Synapsen liegt ein Kopplungsmechanismus zwischen dem präsynaptischen Aktionspotential und der biochemischen Überträgerstoff-Ausschüttung zu Grunde. Dabei werden Ca2+-Kanäle geöffnet und ein Freisetzungssensor Ca2+-abhängig aktiviert, der schließlich die …
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Alternative splicing and RNA editing of the Complexin C-terminus regulates neurotransmitter release in Drosophila
… the protein controls spontaneous and evoked neurotransmitter release through its effects on SNARE complex assembly. The Drosophila cpx locus undergoes alternative splicing to produce two isoforms (Cpx7A and Cpx7B) that differ in the C-terminal ~20 amino acids of Cpx. Although PKA …
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Molecular Basis of Coupling Calcium Sensing to Fast Membrane Fusion by Synaptotagmin-1 in Neurotransmitter Release
Neuronal communication depends on the rapid release of neurotransmitters through Ca2+-triggered synaptic vesicle exocytosis. Synaptotagmin-1 (Syt1) acts as the Ca2+ sensor for fast, synchronous neurotransmitter release. Despite decades of research, the precise molecular mechanism of Syt1 action and …
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Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… the presynaptic effects of alcohol to alter neurotransmitter release remain relatively unexplored. This dissertation addresses whether alcohol-induced changes in transcriptional activity can promote synaptic vesicle fusion and therefore, neurotransmitter release. To identify a transcriptional …
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Regulation of SNARE-Mediated Synaptic Vesicle Release by Synaptotagmins and Complexins
… by synaptic transmission. This process includes release of neurotransmitter from vesicles in the presynaptic neuron into the synaptic cleft, and sensing of these neurotransmitters by the postsynaptic neuron with specific receptors. Long-lasting changes in the strength of synaptic contacts between …
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Structure and Function of Proteins Involved in Regulated Secretion: Synaptotagmins and Complexin
The release of neurotransmitter from neurons is a tightly regulated process. There are a number of proteins required for membrane fusion to occur, and then there are regulatory proteins that allow membrane fusion to proceed at incredible speed with the precise timing necessary for complex functions …
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Inhibition of excitatory neurotransmitter activity by hydrogen sulfide in bovine retina, in vitro
… H2S donor compounds, NaHS and Na2S on excitatory neurotransmitter release in the posterior segment of the mammalian eye, prompting further research on its pharmacological effects in these ocular tissues. So far, no studies have evaluated the pharmacological actions of H2S donor drugs that produce …
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