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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 31 for “"neurotransmitter receptors"”.

  1. Genetic Variation in Neurotransmitter Receptors Generates Behavioral Diversity

    Bendesky, Andres

    … exploitation decision. tyra-3 responds to the neurotransmitter tyramine, which is related to vertebrate adrenaline and noradrenaline. tyra-3 modifies the activity of sensory neurons that detect food cues and that regulate the decision to abandon depleting food resources. In strains that are …

    rockefeller Repository record

  2. Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin

    Nair, Ramya2012

    … Regulationsprotein für den Transport von Neurotransmitterrezeptoren zu der postsynaptischen Membran. Der Verlust von Nbea führt zu einer reduzierten Oberflächenexpression von GABA-A und Glutamate Rezeptoren und somit zu einer Reduktion der GABAergen und Glutamatergen …

    goettingen Repository record

  3. Genetic Risk Factors for PTSD: A Gene-Set Analysis of Neurotransmitter Receptors

    Lewis, MichaelVirginia Tech2020

    … and genetic mechanisms are particularly elusive. Neurotransmitter systems are thought to contribute to PTSD etiology and are the targets of most pharmacotherapies used to treat PTSD, including the only two FDA approved options and a wide array of off-label options. However, the degree to which …

    vt Repository record

  4. Exploring the Neuropeptides, Neuropeptide Receptors and Neurotransmitter Receptors in the Synganglia of Part-Fed Females of <i>Ornithodoros turicata</i> (Argasidae) and <i>Ixodes scapularis</i> (Ixodidae) with Insights Into Their Roles in Contrasting Biology

    Egekwu, Noble I.2019

    … predicting neuropeptides, neuropeptide receptors and neurotransmitter receptors was done, supported by strong e-values (< -6), and high consensus sequence alignments. For the synganglion of <em>I. scapularis</em>, transcripts predicting 23 neuropeptides and/or their receptors were …

    odu Repository record

  5. Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method

    Jue, Stephen Gregory2016

    … of postsynaptic potentials, in terms of neurotransmitter receptor activation, is of clinical significance because information associated with receptor activation can be used in the diagnosis and study of neurological disorders. Single-unit recordings provide a method of measuring …

    calpoly Repository record

  6. ARFGEF mutations: A mechanism for breast-to-brain metastasis

    Allamsetty, Naga HarshithaUniversity of Wolverhampton2025

    … has shown that metastatic brain cancer expresses neurotransmitter receptors and forms synaptic-like connections with neurons, contributing to tumour growth and survival. Exome sequencing of 26 breast-to-brain metastasis (BBM) cancers identified ARFGEF3 mutations in the BBM samples. This suggests …

    wlv Repository record

  7. Investigation of the role of ARFGEF3 in breast to brain metastasis

    Ajaykumar, NandagopalUniversity of Wolverhampton2023

    … that metastasize and grow in the brain express neurotransmitter receptors and form synaptic connections with neurons and these pseudo-synapses contribute to tumour proliferation and survival. In our study, Whole exon sequencing data of 26 breast to brain metastatic (BBM) tumours revealed genomic …

    wlv Repository record

  8. Oligodendrocyte precursor cell states and their regulation

    Kamen, YasmineUniversity of Cambridge2022

    … to through their voltage-gated ion channels and neurotransmitter receptors. Functional expression of these channels and receptors is often described as a defining feature of OPCs, although several reports suggest that OPCs exhibit diversity in their electrophysiological properties. In this …

    cambridge Repository record

  9. Axon/dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy Terminal Domains

    Stowell, Julia NashUniversity of Illinois at Urbana-Champaign2015

    The subcellular targeting of neurotransmitter receptors is vital in controlling polarized information flow in the brain. We show here that metabotropic glutamate receptors are differentially targeted when expressed from defective viral vectors in cultured hippocampal neurons: group I mGluR1a and …

    uiuc Repository record

  10. Molecular Pathogenesis of Spinocerebellar Ataxia type 10

    Lim, Jung gook 1971-The University of Texas Medical Branch at Galveston2013

    … target transcripts, including major inhibitory neurotransmitter receptors, glycine and GABA. Our study also indicated that the sequestration of the RNA-binding proteins by toxic expanded repeats result in complex SCA10 phenotype. We clearly showed that aberrant splicing of GABAARγ2 and GlyRα2 …

    utmb Repository record

  11. Uncovering the Importance of Cell Morphology, Genetic Regulation, and Neuronal Signalling in Quiescent Neural Stem Cells

    Zilinskaite, NemiraUniversity of Cambridge2024

    … and quiescence. scRNA-Seq revealed that specific neurotransmitter receptors are involved in the quiescence. Further investigation was performed on GABAergic and dopaminergic neuron manipulations to understand their impact on quiescence. The experiments revealed a clear neuronal signalling role in …

    cambridge Repository record

  12. Molecular Pathogenesis of Spinocerebellar Ataxia type 10

    Lim, Jung gookThe University of Texas Medical Branch at Galveston2013

    … target transcripts, including major inhibitory neurotransmitter receptors, glycine and GABA. Our study also indicates that the sequestration of the RNA-binding proteins by toxic expanded repeat results in complex SCA10 phenotype. We clearly show that aberrant splicing of GABAARγ2 and GlyRα2 …

    utmb Repository record

  13. N-linked glycosylation is fundamentally linked to the surface expression of neuroligins

    Cast, Thomas, author, Chanda, Soham, advisor, DeLuca, Jennifer, committee member, Di Pietro, Santiago, committee member, Tobet, Stuart, committee memberColorado State University. Libraries2023

    … synaptic transmission strength by recruiting neurotransmitter receptors to synapses. Mutation of N-glycosylated residues increased retention of each NLGN isoform in the endoplasmic reticulum (ER), consequentially reducing their ability to interact with presynapses. Pharmacological inhibition …

    colostate Repository record

  14. Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus

    Javadi, Christopher2017

    … ion channels that are coupled to hormone and neurotransmitter receptors present on NPY neurons, whole-cell patch clamp electrophysiology was performed on identified NPY neurons throughout the rostral-caudal extent of the arcuate nucleus of the hypothalamus. Leptin and insulin acutely …

    utswmed Repository record

  15. An investigation into the mechanisms of angiogenesis and breast cancer metastasis

    Olivares, IvonneUniversity of Wolverhampton2023

    … that this gene is involved in the regulation of neurotransmitter receptors subunits in the BIG3-knockout MCF-7 breast cancer cell line. Neurotransmitter regulation has been shown as one mechanism through which brain tumours integrate into the neuronal signalling network to promote colonisation of …

    wlv Repository record

  16. Structure and Composition of Postsynaptic Densities

    Farley, Madeline2015

    … cytoskeletal proteins, supports and organizes neurotransmitter receptors within the synaptic membrane in addition to bridging signaling with the actin cytoskeletal network. The protein composition and structure of PSDs is known to change in response to synaptic activity and several PSD proteins …

    uthsc Repository record

  17. Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease

    Huang, KunUniversity of British Columbia2008

    … trafficking and function of signaling molecules, neurotransmitter receptors and associated synaptic scaffolding proteins. HIP14 (huntingtin interacting protein 14) is the first identified and characterized mammalian palmitoyl transferase that regulates this process. I have shown that HIP14 has …

    ubc Repository record

  18. Density-Dependent Foraging in Caenorhabditis Elegans

    Greene, Joshua

    … of foraging behavior in animals lacking specific neurotransmitters or neurotransmitter receptors. This screen identified GABA as broadly necessary for ascaroside-suppression of roaming. Through cell specific rescue and inhibition experiments, I show that GABA release from the unpaired AVL neuron …

    rockefeller Repository record

  19. Critical window in autism : a study on Shank3

    Mei, Yuan (Yuan Karen)Massachusetts Institute of Technology2016

    … plasticity and remodeling by regulating many neurotransmitter receptors including NMDAR, AMPAR, and numerous actin-binding regulators. Disruptions of Shank3 in mouse models have robustly recapitulated the cardinal phenotypes of autism including anxiety, social interaction deficits, and …

    mit Repository record

  20. Ampa Receptor Allosterism: Measurement of The Conformational Changes In The Ligand Binding Domain of A Functional Receptor

    Gonzalez-McGehee, Jennifer2010

    Ionotropic glutamate receptors are important excitatory neurotransmitter receptors in the mammalian central nervous system that have been implicated in a number of neuropathologies such as epilepsy, ischemia, and amyotrophic lateral sclerosis. Glutamate binding to an extracellular ligand binding …

    uthsc Repository record

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