Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"neurotransmitter receptor"”.
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Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method
… of postsynaptic potentials, in terms of neurotransmitter receptor activation, is of clinical significance because information associated with receptor activation can be used in the diagnosis and study of neurological disorders. Single-unit recordings provide a method of measuring …
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Genetic Risk Factors for PTSD: A Gene-Set Analysis of Neurotransmitter Receptors
… and genetic mechanisms are particularly elusive. Neurotransmitter systems are thought to contribute to PTSD etiology and are the targets of most pharmacotherapies used to treat PTSD, including the only two FDA approved options and a wide array of off-label options. However, the degree to which …
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Nova Regulation of Alternative Splicing in the CNS
… splicing regulation, exon 3A of glycine receptor α2 subunit (GlyRα2), two new targets are identified, which are the alternative exon, E9 in the inhibitory neurotransmitter receptor subunit, GABAARγ2, and the alternatively spliced exon H in Nova-1's own message. Nova acts to enhance …
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Heterogeneity in the Pitx2ON Population in the Mouse Superior Colliculus
… expression of transcription factors, neurotransmitter receptor genes, and canonical markers suggests a molecularly heterogeneous population. Complementary viral tracing experiments map the connectivity of Pitx2ON neurons. Retrograde tracing from individual downstream targets reveals …
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The Role of Aerobic Glycolysis in the Resting Human Brain
… that regional brain metabolism is correlated to neurotransmitter receptor density. Aerobic glycolysis is highest in regions with a balanced density of excitatory and inhibitory receptors. Taken together, these results demonstrate the functional significance of resting aerobic glycolysis and its …
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Synaptic Protein Profiling in the Mammalian Brain
… particular neurons for expression of a given neurotransmitter receptor fused to an affinity tag. Immunohistochemistry of fixed brain tissue confirmed the correct localization of each synaptic fusion protein to the appropriate cell type and morphological structure. In order to isolate the …
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Computation and Numerics in Neurostimulation
… differential equation based ligand-gated neurotransmitter receptor models are analyzed. A fundamental objective of this research has been to accurately emulate the unique medical characteristics of neurostimulation treatments, with minimal simplification, thereby providing optimal utility …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… In the CNS, signaling through the kainate receptor (KAR) by glutamate causes an increase in ADAM10 expression. Human B cells were found to express a GluK2 containing kainate receptor and its activation increased ADAM10 expression which is in agreement with KAR activation in the CNS. …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… a role in modulating neural factors, including neurotransmitter systems and neuroinflammatory mediators, which may have a negative impact on CNS fatigue. Therefore, the primary objective of these studies is to examine the effects of peripheral MCP-1 on the occurrence of fatigue and CNS …
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Investigation of the role of ARFGEF3 in breast to brain metastasis
… that metastasize and grow in the brain express neurotransmitter receptors and form synaptic connections with neurons and these pseudo-synapses contribute to tumour proliferation and survival. In our study, Whole exon sequencing data of 26 breast to brain metastatic (BBM) tumours revealed genomic …