Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 507 for “"neurotransmitter"”.
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Spektroskopie der Neurotransmitter Tryptamin und Phenylethylamin
… neurons is based inter alia on the binding of a neurotransmitter (NT) to a receptor, wherein the molecular recognition, following the key-and-lock principle, is based on noncovalent interactions. The intra- and intermolecular interactions allow for a certain structural diversity and, depending on …
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Mechanism of Synaptotagmin Action in Neurotransmitter Release
Neurotransmitter release occurs by fusion of the synaptic vesicle membrane with the plasma membrane. Formation of a highly stable complex, known as the SNARE (soluble NSF-attachment protein receptors) complex, brings the two membranes close in space. SNARE complex formation is required but probably …
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Mechanism of Synaptotagmin Action in Neurotransmitter Release
Neurotransmitter release occurs by fusion of the synaptic vesicle membrane with the plasma membrane. Formation of a highly stable complex, known as the SNARE (soluble NSF-attachment protein receptors) complex, brings the two membranes close in space. SNARE complex formation is required but probably …
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Entwicklungsspezifische Wirkmechanismen der Neurotransmitter GABA und Glyzin
… sogenannten Kalziumsignalen, einher. Während die Neurotransmitter GABA und Glyzin Nervenzellen des adulten Gehirns hyperpolarisieren und dadurch Aktivität hemmen, depolarisieren sie paradoxerweise unreife Nervenzellen und rufen dadurch Kalziumsignale hervor. In der vorliegenden Arbeit wurden die …
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Molecular mechanisms of neurotransmitter transport in neurons
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Genetic Variation in Neurotransmitter Receptors Generates Behavioral Diversity
… exploitation decision. tyra-3 responds to the neurotransmitter tyramine, which is related to vertebrate adrenaline and noradrenaline. tyra-3 modifies the activity of sensory neurons that detect food cues and that regulate the decision to abandon depleting food resources. In strains that are …
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Unraveling the Role of SNARE Interactions in Neurotransmitter Release
The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is tightly controlled by an intricate protein machinery. Essential components of this machinery are the synaptic vesicle protein synaptobrevin and the plasma membrane proteins syntaxin 1 and SNAP-25, which are …
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Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
… Regulationsprotein für den Transport von Neurotransmitterrezeptoren zu der postsynaptischen Membran. Der Verlust von Nbea führt zu einer reduzierten Oberflächenexpression von GABA-A und Glutamate Rezeptoren und somit zu einer Reduktion der GABAergen und Glutamatergen …
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Wirkung von Sekretin auf Neurotransmitter im Hippokampus der Ratte
… appliziertem Sekretin auf den Stoffwechsel von Neurotransmittern im Gehirn der Ratte, um damit einen Beitrag zur Klärung der bislang wenig erforschten Funktion von Sekretin im zentralen Nervensystem zu leisten. Anhand von Literaturangaben, die einen Zusammenhang mit Autismus belegten, wurden der …
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Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
Neurotransmitter release is a tightly regulated process that involves synaptic vesicle docking at presynaptic active zones, priming of the vesicles to a release-ready state, and calcium evoked fusion of the vesicle and plasma membranes. The probability of release is modulated by plastic changes …
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Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
Neurotransmitter release is a central event in interneuronal communication. The release machinery includes three SNAREs (soluble N-ethylmaleimide sensitive factor adaptor protein receptor) and Munc18-1 as core components. Munc13, synaptotagmin and complexin underlie the exquisitely tight regulation …
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Insights into the Functions of Munc18-1 in Neurotransmitter Release
Neurotransmitter release is an exquisitely regulated process that transmits signals between neurons. The release process includes: docking of synaptic vesicles at the active zone of the pre-synaptic plasma membrane, priming to a release ready state, and then membrane fusion and release of …
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Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
… werden, dass eine cAMP-bedingte Steigerung der Neurotransmitterfreisetzung sowohl auf eine Erhöhung der vesikulären Freisetzungswahrscheinlichkeit als auch auf eine Zunahme der Zahl freisetzbarer Vesikel zurückgeführt werden kann. In der vorliegenden Dissertation wurde die Beteilung des neuen …
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Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method
… of postsynaptic potentials, in terms of neurotransmitter receptor activation, is of clinical significance because information associated with receptor activation can be used in the diagnosis and study of neurological disorders. Single-unit recordings provide a method of measuring …
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Dissection of the Roles of Synaptotagmins in Calcium Dependent Neurotransmitter Release
Neuronal communication is mediated by neurotransmitter release, which is triggered in response to a calcium influx into the presynaptic cell, caused by the arrival of an action potential. Synaptotagmins (Syts) mediate this calcium-dependent regulation of neurotransmitter release by mechanisms that …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
Protein-Protein Interactions That Regulate Neurotransmitter Release from Retinal Ribbon Synapses Photoreceptors and bipolar cells in the retina form specialized chemical synapses called ribbon synapses. This type of synapse differs physiologically from “conventional” chemical synapses. While …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… shown promise, their efficacy remains limited. Neurotransmitter systems such as oxytocin (OXT), corticotropin-releasing factor (CRF), and serotonin (5-HT) have demonstrated therapeutic potential in reducing alcohol-related behaviors. However, how these neuromodulators alter GABAergic …
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Neurotransmitter patterning in the embryonic ventral nerve cord of Drosophila melanogaster
This work has focused on neurotransmitter specification in the developing fruit fly brain. Neuroblasts constitute the fundamental developmental units of the insect nervous system, each generating a unique lineage. Our understanding of neuroblast lineages at the anatomical level contrasts sharply …
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Structural and Functional Studies of C2-Domain Proteins Involved In Neurotransmitter Release
Neurotransmitter release is mediated by synaptic vesicle exocytosis at presynaptic nerve terminals. This process is extremely fast and strictly regulated by the intracellular Ca2+ concentration. To achieve this exquisite regulation, many proteins are involved. The central fusion machinery includes …
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