Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 226 for “"neurotransmission"”.
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SNAREs in evoked and spontaneous neurotransmission
… zum Teil gegensätzlichen Rollen in der Neurotransmission spielen. Nach unserer Hypothese stabilisiert der N-terminale Teil des Komplexes die geprimten Vesikel, der in einem einfachen Modell der Energielandschaft der Exozytose zusätzlich die vesikuläre Freisetzungswahrscheinlichkeit und …
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Spontaneous Neurotransmission as a Driver of Calcium Signaling
Spontaneous neurotransmission is a stochastic mode of neurotransmitter release that is not coupled to action potential arrival at the presynapse. Recent evidence has shed light upon the presynaptic and vesicular fusion machinery that makes this mode of release unique to action potential driven, or …
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… including cell division, gene transcription and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate either Rac or Rho GTPases, respectively. The RhoGEF1 domain and the Rac pathway are required …
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Stratification transcriptomique de la neurotransmission du gliome humain adulte
… la dérégulation significative de marqueurs de la neurotransmission et de l’immunité. Une deuxième caractérisation du transcriptome du gliome, cette fois-ci sous l’angle de la neurotransmission, a identifié une corrélation négative significative entre la malignité du gliome et la sur-expression des …
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Novel Optical Tools to Investigate Presenilin Control of Neurotransmission
<p>Neurotransmission is a critical function for neurons that underlies the complex processes of the brain. Deficits in synaptic function often manifest in neurodegenerative diseases, motivating the study of control points of neurotransmission. The Endoplasmic Reticulum (ER) has recently been …
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Regulation der Neurotransmission im zentralen Nervensystem durch alpha2-adrenerge Rezeptoren
… bzw. Heterorezeptoren (Dopamin) die Neurotransmission modulieren. Dies könnte in der Zukunft für die Entwicklung neuer, subtypspezifischer Pharmaka von großer Bedeutung sein.
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Age-Related Alterations in Orexin Modulation of Septo-Hippocampal Neurotransmission
… age. To define the role of orexin on hippocampal neurotransmission, orexin A (OxA) was infused into the MS or hippocampus, and hippocampal acetylcholine (ACh), GABA and glutamate efflux were analyzed. OxA increased ACh in young but not aged rats at both MS and hippocampal infusion sites. GABA and …
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Effects of HZE Irradiation on Chemical Neurotransmission in Rodent Hippocampus
… impairments in hippocampal chemical neurotransmission, the hypothesis of this dissertation.</p> <p>In Aim 1 I have focused on the effects of HZE radiation on release of major neurotransmitter systems in the hippocampus. I have further extended my research on the levels of receptors of …
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Putative changes in dopaminergic neurotransmission following nicotine induced behavioural sensitisation
… and elucidate putative changes in dopaminergic neurotransmission of behaviourally sensitised animals. If so, this improved understanding of behavioural sensitisation could provide a better understanding of the pathophysiologies of neuropsychiatric disorders and provide more insight into why …
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Protons and Potentials: How Neurotransmission Influences and is Influenced by pH Transients
… ions can overwhelm endogenous buffering during neurotransmission and can form transient increases or decreases in pH. These transients can modulate neuronal activity by altering neuronal excitability, either by inhibiting or potentiating ion channels or by acting on receptors. Changes in pH and …
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L-threonine : its ability to increase glycine mediated neurotransmission and suppress spasticity
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1989.
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Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5
… suggest that the enhancement in excitatory neurotransmission which initially led to improvements in learning and plasticity preceded excessive excitability and subsequent neuropathology. Consequently, Cyclin-dependent kinase 5 regulates excitatory neurotransmission, synaptic plasticity.
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Individual sensitivity to novelty and (+)-3,4-methylenedioxymethamphetamine: Roles for serotonin and GABA neurotransmission
… and found a critical role for serotonin (5-HT) neurotransmission, in particular the 5-HT2A receptor (5-HT2AR) in the nucleus accumbens (NAc) and prefrontal cortex (PFC). We then carried this finding into a model of individual difference in which animals are separated based on their differential …
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Characterization of synaptotagmin 7 function in neurotransmission and its subcellular localization at synapses
Synaptic vesicle (SV) fusion is dependent on proteins that can sense Ca²⁺ and trigger fusion with the plasma membrane. Neurotransmitter release occurs during a rapid synchronized phase of SV fusion mediated by the Ca²⁺ sensor Synaptotagmin 1 (SYT1). A slower SYT1-independent asynchronous phase is …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… may alter brain circuits related to dopamine neurotransmission. It increases the behavioural responses of dopamine agonists and is possibly associated with hypersensitivity of some postsynaptic dopamine receptors. These effects were partially prevented by exendin-4, which may elicit some …
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