Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"neurotensin"”.
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ASSESSMENT OF NEUROTENSIN RECEPTOR AGONIST EFFECTS ON FEAR-POTENTIATED STARTLE
… that more research is needed to examine the neurotensin system and sex differences. Overall, these findings support targeting the neurotensin system for the development of novel strategies for treating anxiety disorders.</p>
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Effects of selective neurotensin receptor antagonists on responding for brain stimulation reward
… and by ventral mesencephalic microinjections of neurotensin (NT); these findings suggest that this neuropeptide may be an important component of the mesencephalic reward-relevant pathway. The present work was aimed at testing this hypothesis by studying the effects of systemic administration of …
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INTRACRANIAL INFUSIONS OF NEUROTENSIN AGONISTS PRODUCE AN ANXIOLYTIC PROFILE IN A RAT ULTRASONIC VOCALIZATION MODEL
<p>Neurotensin (NT) is a peptide neurotransmitter that interacts with brain monoamine neurotransmitter systems. It has been demonstrated that neurotensin type 1 and type 2 receptor agonists influence animal models of psychological disorders and pain regulation, respectively. It has already been …
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The interactive and individual effects of orexin A and neurotensin in the brain on spontaneous physical activity.
… activity. In chapter one, we chose to study neurotensin signaling in the ventral tegmental area as a possible downstream event of orexin receptor activation in the rostrolateral hypothalamus. Firstly we performed immunohistochemical studies which confirmed the colocalization of …
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Effects of N-Methyl-D-Aspartate receptor blockade on cross-sensitization between D-Tyr11 neurotensin and amphetamine
Blockade of neurotensin (NT) receptors with SR-48692 prevents the development of sensitization to the locomotor activating effects of amphetamine (AMPH). In addition, repeated icv injections of NT or of its analog, D-Tyr 11 NT, sensitize animals to the locomotor activating effects of AMPH. Recent …
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ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
<p>Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans …
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Synthese und Charakterisierung Cyclam-basierter Multimere als Basis für Radiopharmaka
… von Acrylamid-Arg-Tyr-OH und Acrylamid-Neurotensin(8-13)-OH an Cyclam zu den gewünschten tetrameren Verbindungen. Das Neurotensintetramer mit vier zielsuchenden Einheiten wurde für weiterführende radiochemische und radiopharmakologische Untersuchungen eingesetzt. Es kann unter milden …
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NTS2-selective analogs as an alternative treatment to chronic pain
… are independent of the opioidergic system. The neurotensinergic system has emerged as an interesting candidate for this purpose. Indeed, neurotensin (NT) receptors NTS1 and NTS2 are highly expressed in regions involved in pain control and have demonstrated strong analgesic properties in vivo. …
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ΤΑ ΠΕΠΤΙΔΙΑ ΣΩΜΑΤΟΣΤΑΤΙΝΗ, ΝΕΥΡΟΤΑΣΙΝΗ ΚΑΙ Β-ΕΝΔΟΡΦΙΝΗ ΣΤΟ ΚΕΝΤΡΙΚΟ ΝΕΥΡΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΣΚΑΝΤΖΟΧΟΙΡΟΥ ΚΑΙ ΤΟΥ ΠΡΟΒΑΤΟΥ
… REGIONAL DISTRIBUTION OF SOMATOSTATIN (SRIF)-, NEUROTENSIN (NT)-, AND B-ENDORPHIN-CONTAINING NEURONS IN THE HEDGEHOGAND SHEEP CENTRAL NERVOUS SYSTEM WERE INVESTIGATED USING IMMUNOCYTOCHEMISTRY.FROZEN CORΟNAL SECTIONS OF THE BRAIN AND SPINAL CORD WERE PROCESSED FOR IMMUNOCYTOCHEMICAL STAIN …
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Towards the synthesis of RP66453
… bacteria which is shown to bind to the neurotensin antagonist of guinea pigs. RP 66453 provides an attractive target as its bis-macrocyclic core contains a biaryl axis that displays atropisomerism. The natural atropisomer of RP 66453 is less stable than its diastereoatropisomer. To date …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… peptide and the small regulatory peptide, the neurotensin (NT). Metal conjugates of these bioactive peptides were successfully synthesized by solid phase peptide synthesis (SPPS) which was used not only for the covalent bonding of the metallocenes to the peptides but also for the complexation …
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… whereas leucine-enkephalin, dynorphin and neurotensin increased ipsilaterally in the central nucleus of the amygdala. Sham MCAO was ineffective.;Neurochemical changes were assessed 5 days after localized excitotoxic lesion of the IC or primary somatosensory cortex (SSC-I). Damage to the IC …
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New stimulators and a new mechanism of regulated secretion in pituitary gonadotropes
… mechanism. Endothelin-1, oxytocin, neurotensin, pituitary adenylate cyclase-activating polypeptide, and serotonin raised (Ca$\sp{2+}\rbrack\sb{\rm i}$ and evoked LH release as assayed by the reverse hemolytic plaque assay (RHPA). These agents affected only subpopulations of …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… (CoA), somatostatin (SOM), serotonin (SER), NPY, Neurotensin (NeuroT)) were used to assess the development of the ENS and enteroendocrine cells (EECs), respectively. At PD1, the ENS of AGA animals was almost fully developed compared with PD14 and PD28. For SGA piglets, a delayed development of …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
… with the other distinguished by expression of neurotensin (Nts). Another major EEC subpopulation, enterochromaffin (EC) cells could be split into three groups, mechanosensitive and pro- inflammatory EC cells distinguished by Piezo2 and Tac1 expression, respectively and a third Sct-expressing …
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Arc expression in the parabrachial nucleus following taste stimulation
… peptide RNA; and 20 % co-expressed neurotensin RNA. This co-expression with multiple different neuropeptides suggests that bitter-activated Arc expression mediates multiple neural responses to the taste event, such as taste aversion learning, suppression of food intake, increased …
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Entwicklung neuer radioaktiver Kupferkomplexe hoher Stabilität auf der Basis sechszähniger 3,7-Diazabicyclo[3.3.1]nonan-Derivate
… Strukturen erfolgte anhand der Peptidsequenzen Neurotensin(8-13) und Bombesin(7-14). Dabei konnte demonstriert werden, dass eine Erhöhung der Ausbeuten an Peptidkonjugat ausgehend von Spacer-funktionalisierten Liganden erzielt werden kann. • Die radioaktive Markierung der Bispidin-Liganden mit …