Global ETD Search
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Showing 1 to 15 of 15 for “"neurosteroids"”.
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Neurosteroids: endogenous analgesics?
… for many clinical drugs, and certain endogenous neurosteroids act as potent allosteric modulators of these receptors. A developmental change in the rate of exponential decay of GABAergic synaptic events has been observed in other types of neurones and this may be related in part to fluctuations …
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Neuroprotectant Properties of Neurosteroids During Neonatal Ethanol Exposure
… measurements in a sex-dependent manner, with neurosteroids having minimal to no effect on females and differential effects on ethanol-treated and intubated-control males. These effects could be explained by the difference in the timing of the switch of the GABAA receptor from excitatory to …
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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids
… effects. Since the precursor to, and the neurosteroids all produce vasoactive effects, it is important to identify the molecular mediators modulating these effects. This body of work examines the cerebrovascular effects of and determines the mechanisms of action by which the neurosteroids …
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Investigation of two Interacting Neurosteroid Sites on a GABA Receptor by Mutagenesis and Mathematical Modeling
… GABA receptor, UNC-49, is modulated by the neurosteroids pregnenolone sulfate and pregnanolone, identifying neurosteroids as potential lead compounds. Notably, neurosteroid sites are non-conserved between invertebrates and mammals, limiting possible cross-toxicity. This proposal is focused …
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The Steroid Sulfatase Inhibitor (p-O-Sulfamoyl) - Tetradecanoyl Tyramine (DU-14) Enhances Memory Retention in Passive Avoidance in Rats with Hippocampal Cholinergic Deficit
Neurosteroids, such as dehydroepiandrosterone sulfate, (DHEAS) are steroidal compounds synthesized within the central nervous system that modulate its function. Among the effects associated with sulfated neurosteroids is the enhancement of memory. Previous studies have demonstrated that altering …
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Endogenous neurosteroid actions at GABAA receptors during neuronal development
… manufacture GABA-modulatory steroids, termed “neurosteroids”, from cholesterol. Although several studies have demonstrated neurosteroids to be implicated in a variety of physiological processes including neurodevelopment, important questions remain. In particular, are neurosteroids neurone …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… trauma and the GABRA2 gene.<br/><br/>Certain neurosteroids are known to bind to and enhance the function of GABAARs. Furthermore, the brain levels of such steroids are changed by acute and chronic stress. I have identified an endogenous capacity to synthesise these GABAAR-active neurosteroids …
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Ruolo dei neurosteroidi nella modulazione dopaminergica
Cogent evidence shows that neurosteroids play a key role in the modulation of dopaminergic responses in the brain. Several findings have shown that these compounds can affect the severity of DRT- induced effects in well validated animal models. Over the last few years, we have characterized that …
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Synthesis and evaluation of β-fluoro-γ-aminobutyric acid enantiomers
… was motivated to explore the mode of action of neurosteroids at GABA receptors. The observation that the C-F bond has a strong preference to align gauche to the C-N+ bond in protonated β-fluoroamines stimulated the enantioselective synthesis of 3-fluoro-GABA enantiomers. This was achieved from …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… this observed change in activity was produced by neurosteroids raises questions not only related to the regulatory mechanisms itself, but also to the possible role of neurosteroid in modulating glutamate transport.
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… this observed change in activity was produced by neurosteroids raises questions not only related to the regulatory mechanisms itself, but also to the possible role of neurosteroid in modulating glutamate transport.
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… (PS) is one of the most commonly occurring neurosteroids in the central nervous system and influences function of several receptors. PS modulates NMDARs and has been shown to have both positive and negative modulatory effects on NMDAR currents generally in a subtype-selective manner. We …
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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development
… In addition to mediating stress responses, neurosteroids influence CNS-specific processes known to regulate neural development and pathology. Multiple sclerosis (MS), a debilitating neurodegenerative disorder classified by rampant demyelination, exemplifies the neuroendocrine crosstalk …
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Regulation und Expression von P450scc im Nervensystem
Neurosteroide sind Steroidhormone, die im Nervensystem de novo aus Cholesterin oder einem anderen frühen Vorläufersteroid synthetisiert werden. Im Gegensatz zu den klassischen Steroidhormonen der Nebenniere und der Gonaden, die ihre Zielorgane über die Zirkulation erreichen, wirken Neurosteroide …
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Understanding the Structure and Function of GABAA Receptors Using Cryo-Electron Microscopy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.