Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"neurosteroid"”.
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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development
… in the brain and spinal cord are referred to as neurosteroid or neuroactive hormones and encompass estrogens, androgens, glucocorticoids, and mineralocorticoids. Though all substrates and enzymes required for neurosteroid biosynthesis exhibit CNS expression, a thorough comprehension of their …
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Endogenous neurosteroid actions at GABAA receptors during neuronal development
… manufacture GABA-modulatory steroids, termed “neurosteroids”, from cholesterol. Although several studies have demonstrated neurosteroids to be implicated in a variety of physiological processes including neurodevelopment, important questions remain. In particular, are neurosteroids neurone …
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Investigation of two Interacting Neurosteroid Sites on a GABA Receptor by Mutagenesis and Mathematical Modeling
… GABA receptor, UNC-49, is modulated by the neurosteroids pregnenolone sulfate and pregnanolone, identifying neurosteroids as potential lead compounds. Notably, neurosteroid sites are non-conserved between invertebrates and mammals, limiting possible cross-toxicity. This proposal is focused …
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Neurosteroids: endogenous analgesics?
… for many clinical drugs, and certain endogenous neurosteroids act as potent allosteric modulators of these receptors. A developmental change in the rate of exponential decay of GABAergic synaptic events has been observed in other types of neurones and this may be related in part to fluctuations …
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Neuroprotectant Properties of Neurosteroids During Neonatal Ethanol Exposure
… apical dendritic length and intersections. Neurosteroid treatment affected neuronal measurements in a sex-dependent manner, with neurosteroids having minimal to no effect on females and differential effects on ethanol-treated and intubated-control males. These effects could be explained by …
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The Effects of Allopregnanolone on Feeding: A Behavioural Investigation
Allopregnanolone (5α-pregnan-3α-ol-20-one), a neurosteroid, has been shown to produce hyperphagia in rodents. The effects of allopregnanolone on appetitive and Consummatory behaviors associated with feeding were examined. Allopregnanolone had no effect on consummatory behaviors, as measured by the …
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Ruolo dei neurosteroidi nella modulazione dopaminergica
Cogent evidence shows that neurosteroids play a key role in the modulation of dopaminergic responses in the brain. Several findings have shown that these compounds can affect the severity of DRT- induced effects in well validated animal models. Over the last few years, we have characterized that …
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Synthesis and evaluation of β-fluoro-γ-aminobutyric acid enantiomers
… are then presented and the synthesis of neurosteroid antagonists acting at GABAA receptors is reported. The synthesis of such compounds was motivated to explore the mode of action of neurosteroids at GABA receptors. The observation that the C-F bond has a strong preference to align gauche …
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The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women
… in circulating allopregnanolone (an anxiolytic neurosteroid implicated in cyclic changes in anxiety and benzodiazepine sensitivity) levels across the estrous cycle. Finally, Chapter 7 translated the rat findings of Chapter 2 to humans by showing that self-reported anxiety and mood symptoms …
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La clozapine et les neurostéroïdes dans la modulation de comportements associés au suicide dans un modèle murin de schizophrénie
… works has revealed that clozapine alters central neurosteroid (NS) levels, such as allopregnanolone. The present work was to evaluate if the effectiveness of clozapine for reducing the risk of recurrent suicidal behaviors is mediated through NS modulation. Finasteride, a 5α- reductase inhibitor …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… this observed change in activity was produced by neurosteroids raises questions not only related to the regulatory mechanisms itself, but also to the possible role of neurosteroid in modulating glutamate transport.
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… this observed change in activity was produced by neurosteroids raises questions not only related to the regulatory mechanisms itself, but also to the possible role of neurosteroid in modulating glutamate transport.
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… (PS) is one of the most commonly occurring neurosteroids in the central nervous system and influences function of several receptors. PS modulates NMDARs and has been shown to have both positive and negative modulatory effects on NMDAR currents generally in a subtype-selective manner. We …
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Il trattamento neonatale con estradiolo modifica l'espressione e la funzione dei recettori GABAA e la sensibilità allo stress nel ratto adulto
… rats in diestrus 1, which have opposite neurosteroid levels than estradiol-treated rats, show the same functional changes in GABAARs as estradiol-treated rats. Allopregnanolone plays an important role in hypothalamic-pituitary-adrenal (HPA) homeostasis and in the stress response. Thus, it …
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La separazione dalla prole reverte le modificazioni nell'espressione di BDNF, proteina Arc, spine dendritiche, LTP e neurogenesi osservate durante la gravidanza e dopo il parto
… increase of LTP and to a dramatic reduction of neurosteroid content compared to control rats. Separation of pups from their dams induced a marked reduction of DSD, BDNF and Arc protein, the amount of which felt at values markedly lower than control. Finally, we observed an increase of …
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Neonatal exposure to estradiol in female rats influences neuroactive steroid concentrations and behaviour in the adult rat
The gonadal steroids, in particular estradiol, exert an important action during perinatal period in the regulation of sexual dimorphism and neuronal plasticity, and in the growth and development of nervous system. Exposure of the developing female to estrogens during perinatal period may have …