Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 104 for “"neuropsychiatric disorders"”.
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Identification of biological markers for neuropsychiatric disorders
… be of importance for the course and prognosis of disorders in the elderly. Dementia and depression have triggered special interest due to the remarkable personal, financial and social burden that may cause to patients and their caregivers. In this respect, the possible relationship between these …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… human genome is involved in the development of neuropsychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD), but the causal genomic molecular players remain unclear. Therefore, in this thesis, we evaluated disorder-associated disruptions …
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Exploring the role of Rapgef6 in neuropsychiatric disorders
Schizophrenia is highly heritable yet there are few confirmed, causal mutations. In human genetic studies, we discovered CNVs impacting RAPGEF6 and RAPGEF2. Behavioral analysis of a mouse modeling Rapgef6 deletion determined that amygdala function was the most impaired behavioral domain as measured …
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MicroRNA Dysregulation in Neuropsychiatric Disorders and Cognitive Dysfunction
… involvement of miRNAs in the development of neuropsychiatric disorders and cognitive dysfunction. In addition, the identification of key players in miRNA dysregulation has implications for both basic and translational research in psychiatric disorders and cognitive dysfunction.
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Identification of natural TSC-Associated Neuropsychiatric Disorders (TAND) clusters
… Conference coined the term TAND (TSC-Associated Neuropsychiatric Disorders) to capture the multidimensional concerns seen in TSC, and recommended that each person with TSC should be screened for TAND every year. To facilitate the process, a TAND Checklist was designed. Many professionals and …
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Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders
Neuropsychiatric Disorders are the leading category contributing to disability-adjusted life years (DALYs) in the U.S. according to the World Health Organization. These findings underline the vast burden caused by neuropsychiatric disorders on patients. However, effective treatments do not exist …
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Mapping Molecular Changes in Human Neuropsychiatric Disorders to Zebrafish Behavioral Profiles
… understanding the etiology of human psychiatric disorders has remained elusive. Recent advances in molecular profiling have allowed researchers to probe genetic and transcriptomic differences in post-mortem samples from individuals with healthy and diseased brains, which has provided some hints …
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Striatal Control of Sensory-Driven Behavior and Its Relevance for Neuropsychiatric Disorders
… this process are associated with a wide range of neuropsychiatric symptoms, including impulsivity and attentional deficits, making it critical to understand the underlying neural basis. In this study, we examined how the tail of the striatum (TS), a major sensory hub within the basal ganglia, …
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Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
Research into the genetic basis of human disease has progressed rapidly over the past 20 years. Genome-wide association studies have identified thousands of links between common variants and phenotypic outcomes. More recently, whole exome and genome sequencing has catalogued patterns of ultra-rare …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
Neuropsychiatric disorders such as anxiety, depression, and substance use disorders are highly prevalent disorders and immensely costly to society. Treatment options are limited, and cocaine use disorder in particular, has no FDA approved pharmacotherapeutic. These disorders are highly comorbid and …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… An altered BBB has been described in various neuropsychiatric disorders. The brain-specific microvascular endothelial cell (BMEC) is an essential structural component of the BBB. To test if integrity of the BBB formed by BMECs is compromised in 22q11.2 deletion syndrome (also called DiGeorge …
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Pilot validation of the Tuberous Sclerosis Associated Neuropsychiatric Disorders (TAND) checklist as a screening tool for neuropsychiatric manifestations
Includes abstract. Includes bibliographical references.
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A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… this platform to characterize the effects of neuropsychiatric treatments and CNS ligands on the T cell signalling repertoire. We apply it to define cell signalling network abnormalities in PBMCs from drug-naïve first-onset schizophrenia patients (n=12) relative to healthy controls (n=12) which …
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A Potential Role For Sap97 In Psychiatric Disorders
… further understand the genetic architecture of neuropsychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia (SCZ). We attempt to understand the functional significance of the gene synapse associated protein of 97KDa (SAP97) and identify a novel role for SAP97 in the …
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… during early cortical development contribute to neuropsychiatric disorders. Genetic interventions are known to cause these disorders but underlying mechanism remains unclear. Human FEZ1 gene is associated with a few mental diseases. In this thesis, we seek to determine function of FEZ1 during …
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Putative changes in dopaminergic neurotransmission following nicotine induced behavioural sensitisation
… It is a phenomenon thought to underlie many neuropsychiatric disorders (e.g. schizophrenia, addiction, depressive disorders, dyskinesia, and psychosis) although its own mechanism remains contentious. In this thesis a multidisciplinary approach was used to investigate the role of dopamine in …
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Statistical Methods for Extracting and Comparing Patterns in Multimodal Neuroimaging Studies
… of brain health and the etiology of neuropsychiatric disorders. But the inherent complexity and dimensionality of these data necessitate new statistical methods to produce replicable and interpretable results. In this work, we contribute to a growing body of methodological research in …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… impulse control is a pervasive hallmark of many neuropsychiatric disorders, such as bipolar disorder, pathological gambling, schizophrenia, substance use disorders, obesity, etc. Characterized as action without thinking, impulsive behavior is recognized as a complex, behavioral endophenotype with …
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Lentiviral-mediated gene delivery to investigate the functional role of neuropsychiatric genes
… that may contribute to the risk of developing neuropsychiatric disorders. For example, dopamine receptor genes are established candidates for a number of psychiatric disorders such as Parkinson’s Disease, alcohol addiction and mood disorders. On the other hand, a gene of unknown function, AUTS2 …
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