Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"neuropsychiatric diseases"”.
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NOVEL APPROACHES TO MODELING AND TREATMENT OF COGNITIVE DEFICITS IN NEUROPSYCHIATRIC DISEASES
Kognitive Defizite und Beeinträchtigungen höherer Hirnfunktionen sind die meist belastenden Aspekte neuropsychiatrischer Erkrankungen (z.B. Elvevag & Goldberg, 2000). Bis jetzt existieren keine zufriedenstellenden Therapien zur Behandlung kognitiver Störungen bei neuropsychiatrischen Erkrankungen …
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Ultra-high Field MRI Methods for Precise Anatomical and Spectroscopic Measurements in the Brain and Application to Neurological and Neuropsychiatric Diseases
<p>Neurological and neuropsychiatric diseases and disorders are a major burden on society, impairing the health and functioning of millions of people every year. There is a need to define the biological bases of these diseases and identify potential biomarkers to improve diagnosis, monitoring, and …
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Mapping genes for X-linked disorders / by Agi Kyra Gedeon.
… genetic delineation of rare X-linked morogenic neuropsychiatric diseases and other X-linked disorders, and identifies two new genes.
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Unravelling the D1R-D2R heteromer
… complex is linked to the etiology of various neuropsychiatric diseases. Formation of the D1R-D2R heteromer is thought to be dependent upon electrostatic interactions occurring between the carboxyl tail of D1R and the third intracellular loop of D2R. Using this interaction site as template, I …
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ADENOSINE SYSTEM DYNAMICS AND SK CHANNELS MODULATE BASOLATERAL AMYGDALA PYRAMIDAL CELL EXCITABILITY: IMPLICATIONS FOR ANXIETY DISORDERS AND COMORBID ETHANOL ABUSE
… researchers have turned their attention to the neuropsychiatric diseases that may precede or become exacerbated by AUDs. While motivation for alcohol consumption can vary by individual, clinical and epidemiological evidence indicates a robust comorbidity between AUDs and anxiety disorders. For …
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THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
… of 5-HT1A R signaling results in various neuropsychiatric disorders such as depression, anxiety and schizophrenia. Thus, 5-HT1A Rs are a good target for the treatment of the neuropsychiatric diseases. Previous studies have shown that 5-HT1A Rs can be SUMOylated by SUMO1 in rat brain areas …
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A chronically implantable neural device for on-demand microdosing of deep brain structures
Chronic neuropsychiatric diseases are increasingly consuming a larger portion of healthcare costs, in part due to a lack of effective treatment techniques. Through research into the pathology of these diseases we now know that most of these disorders are due to a loss in synchrony in a specific …
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Converging biochemical pathways in psychiatric disorders
According to the World Health Organization, neuropsychiatric diseases account for approximately one third of years lost to disability. Yet, despite this huge disease burden, there is a lack of new treatments under development: approved treatments all essentially target the same target(s), if the …
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Computational Methods and Analyses for Assessing Cerebellar Electrophysiology with Magneto- and Electroencephalography
… been implicated in some of the most prevalent neuropsychiatric diseases including autism and schizophrenia, with new information implicating the cerebellum in neurodegenerative dementias and Parkinson's disease as well. Despite advances in our understanding of cerebellar structure and function …
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Experience-Dependent and Input-Specific Regulation of Neocortical Circuit Development by Genes Linked to Neurodevelopmental Disorders
… connectivity has been widely observed in human neuropsychiatric diseases. Specifically, patients with neurodevelopmental disorders like autism often show an imbalance in the local versus long-range connectivity for cerebral cortex. Whether and how genes implicated in neurodevelopmental disorders …
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Enduring Effects of Early Life Inflammation on Stress-related Microglial, Neuronal and Behavioral phenotypes
… have been found in human studies of various neuropsychiatric diseases, these findings suggest that maternal obesity and neonatal infections heighten the risk for their development by way of microglial pathology.
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DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
… associated with cognitive deficit across many neuropsychiatric diseases, such as schizophrenia. Yet, the mechanisms underlying the loss in PVIs and E/I imbalance are not completely understood. Here, I demonstrate that the genetic ablation of the intracellular fibroblast growth factor 14 …
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Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
The 5-HT2A receptor (5-HT2AR) is implicated in neuropsychiatric disorders such as schizophrenia and is thought to mediate the actions of a number of hallucinogenic and antipsychotic drugs. Additionally, certain polymorphic variants of the receptor, such as an allele resulting in substitution of …
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Mechanisms of apathy in health and Parkinson's disease
… are common and debilitating consequences of many neuropsychiatric diseases, including Parkinson's disease. Despite their prevalence and prognostic importance, their underlying mechanisms remain poorly understood. This knowledge gap presents a barrier to clinical assessment and treatment. Previous …
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Effects of transcranial magnetic stimulation over the dorsolateral prefrontal cortex on cognitive control and on the autonomic nervous system
… be investigated in further studies. In several diseases accompanied by disorders of inhibition of ongoing responses, e.g. attention deficit hyperactivity disorder (ADHD), Parkinson’s disease or schizophrenia other therapeutic interventions could be supported by TMS over the right DLPFC. Further …
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The brain age gap in social anxiety disorder
… an increased risk for developing brain-related diseases and cognitive decline. There is growing evidence of advanced brain ageing in neuropsychiatric diseases. Social anxiety disorder (SAD) is a disabling mental illness, which has been associated with both structural brain deficits and advanced …
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Pharmacological Study of the Behavioral Effects of Biologically Active Substances of Plant Origin in Experimental Animal Models of Depression // Фармакологично проучване на поведенчески ефекти на биологично активни вещества от растителен произход в модели на депресия при опитни животни
Дисертационният труд представлява задълбочено научно изследване на ефекти на плодов сок от Aronia melanocarpa и фенолните киселини ‒ хлорогенова, ферулова и галова при експериментални модели на поведенчески нарушения при плъхове, предизвикани от овариектомия и булбектомия. За първи път са …
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NEW PHARMACOLOGICAL TOOLS FOR AUTISM RESEARCH: OXYTOCIN RECEPTOR MUTANT MICE AND ZEBRAFISH AS NEUROBEHAVIOURAL MODELS
… zebrafish potential as a screening tool for neuropsychiatric diseases involving deficits in social behaviour. To this end, we analyzed the effect of OT, AVP but most importantly isotocin (ISO) and vasotocin (AVT) (zebrafish homologues of OT and AVP, respectively) using the shoaling preference …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… indirectly contribute to neurodegenerative and neuropsychiatric diseases such as Schizophrenia and Parkinson’s disease later in life due to early neuronal damage or stress. Many diverse viruses are capable of invading the neonatal CNS including Borna Disease Virus, Coxsackievirus (CV), Herpes …