Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 180 for “"neuroprotection"”.
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Microglia-Mediated Neuroprotection from Concussion
… specific microglial pathways involved in neuroprotection against concussion.
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Bioenergetic neuroprotection in experimental glaucoma
… levels. This thesis investigates bioenergetic neuroprotection in experimental glaucoma and specifically the effects of pyruvate supplementation in facilitating neuroprotection or recovery of compromised, but not dead, RGCs. The thesis consists of two related but independent sections. The first …
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MECHANISMS OF NEUROPROTECTION IN SCN2.2 CELLS
… cellular mechanisms underlying this endogenous neuroprotection in SCN2.2 cells. Extracellular regulated kinase (ERK) is expressed in the SCN, activated by Glu, and is anti-apoptotic in other systems. Therefore, this thesis was designed to test the following central hypothesis: SCN2.2 cells are …
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Neuroprotection by Chitosan and Chitosan Nanoparticles
… on our previous successful explorations of the neuroprotection by chitosan and chitosan nanoparticles (Chi-NPs) in SCI related cell and tissue studies, we further investigated the neuroprotective effects based on two major characteristics of chitosan: (1) molecular weight (MW) and (2) degree of …
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Steroid induced neuroprotection of damaged photoreceptor cells
Retinitis Pigmentosa (RP) is the name given to a group of hereditary diseases causing progressive and degenerative blindness. RP affects over 1 in 4000 individuals, making it the most prevalent inherited retinal disease worldwide, yet currently there is no cure. In 2011, our group released a paper …
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Exercise induced neuroprotection in spontaneuosly running rats
… the effects of voluntary exercise on neuroprotection after unilateral lesions with 6-hydroxydopamine. Rats were divided into runners (had access to running wheel) and non-runners (their running wheels were immobilised). Two weeks after injection of the neurotoxin, the rats were …
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Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones
… the development and investigation of a mode of neuroprotection which was effective in protecting against these factors. Additionally, the optimal culturing conditions for neurone survival were determined and the efficacy of two cell viability assays established. Examination of excitotoxicity and …
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
The transcriptional coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum of patients with Huntington’s Disease (HD). HD is an autosomal dominant neurological disorder caused by a polyglutamine repeat in the …
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Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
Oxidative stress induced increases of the free radicals, which has an important role in neuronal death. Free radicals oxidize intracellular molecules, the destabilization of membrane integrity, and the mitochondrial dysfunction. In present study, we investigated whether AG490, a specific Janus …
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A study of neurodegeneration and neuroprotection in Nothobranchius guentheri
… to Nothobranchius aging and resveratrol induced neuroprotection.
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… provided evidence to implicate these changes in neuroprotection and cardiac consequences of stroke.
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The Role of Fractalkine-mediated Neuroprotection in the Diabetic Retina
Diabetic retinopathy (DR) is a leading cause of blindness worldwide due to hallmarks that include neuronal loss, microgliosis, and vasculature damage. Evidence suggests neurodegeneration and neuronal loss precedes vascular dysfunction in early diabetes. Inflammation caused by microglia exacerbates …
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ApoE2-Mediated Neuroprotection Against Alzheimer’s Disease: from Mechanism to Translation
Alzheimer’s disease (AD) is the most common form of age-related dementia. Despite decades of research, the etiology and pathogenesis of AD are not well understood. Brain glucose hypometabolism has long been recognized as a prominent anomaly that occurs in the preclinical stage of AD. Recent studies …
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Visual Outcome Measures of Remyelination and Neuroprotection in Multiple Sclerosis
… best suited for assessment of remyelination and neuroprotection for use in MS research and clinical trials of remyelination. During my PhD, I collected VEP, OCT, visual acuity, colour vision, oculometry, and blood biomarker measures on approximately 180 people with MS and 30 healthy volunteers …
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Closing Research Gaps for Cerebral Palsy Prevention and Magnesium Sulphate Neuroprotection
… women at risk of very preterm birth for fetal neuroprotection reduced CP risk (high-quality evidence). CP risk was probably increased (moderate-quality evidence, 2 reviews), probably not changed (moderate-quality evidence, 1 review), or unclear (low- to very low-quality evidence, 11 reviews) …
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Effects of oxidative stress and neuroprotection in apoptosis in neuronal cell models
… were also investigated. BDNF showed no specific neuroprotection, however the preliminary data does warrant further investigation. AA showed a 'janus face' showing either anti-oxidant action and neuroprotection or pro-oxidant action depending on the situation. Results showed that the toxic effects …
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Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… and apoptosis, has been shown to confer neuroprotection following ischemic stroke in animal models. In this work, we not only successfully fabricated GNPs with a uniform shape, but also demonstrated the ability of these GNPs to pass into the brain parenchyma following intranasal …
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Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
Protrudin — a transmembrane scaffold protein found in tubular regions of the endoplasmic reticulum (ER) — has previously been shown to strongly promote neuronal survival and axon regeneration after central nervous system (CNS) injury. This is in part due to increased levels of integrins in the …
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Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection
… as a central player transducing ACM-mediated neuroprotection. To identify additional proteins contributing to the protective activity, endogenous neuronal PI3K was immunoprecipitated from astrocytes exposed to ACM or control media, and MS/MS analyses were undertaken. MS data analyses pointed …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… techniques for quantifying remyelination and neuroprotection – multifocal VEP and saccadometry – in cohorts of people with MS and in the setting of the CCMR Two trial. Instead, when these studies were delayed, I embraced an opportunity to help the Cambridge COVID-19 research effort, working on …
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