Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"neuroplasticity"”.
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Constructive spiking neural networks for simulations of neuroplasticity
… in spiking neural networks and simulations of neuroplasticity. This theory is applied in the development of a constructive algorithm based on spike-timing- dependent plasticity (STDP) that achieves continual one-shot learning of hidden spike patterns through neuron construction. The theoretical …
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Neuroplasticity, Neurorehabilitation, and New Hope for Brain-Injured Persons
… century, evidence began to emerge validating neuroplasticity, the idea that the human brain can heal after insult or injury, and treatments can now be individualized based upon neuroplastic principles that provide hope for the brain injured.
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Neuroplasticity: induction and modulation by external stimulation and pharmacological intervention
Neuroplastizität, die Möglichkeit des menschlichen Gehirns sich strukturell und funktionell zu reorganisieren, ist schon lange ein Gegenstand der neurowissenschaftlichen Forschung. Fortschritte in der Transkranialen Magnetischen Stimulation (TMS) und Transkranialen Gleichstromstimulation (tDCS) …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
<p>Compulsivity is a feature of many psychiatric disorders, resulting in distressing and challenging to treat symptoms. Compulsivity is a key feature of obsessive compulsive disorder, which can hinder a person's life and ability to work. Selective serotonin reuptake inhibitors are the current …
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Cholinergic enhancing strategies and brain neuroplasticity. From preclinical evidence to clinical applications.
Cholinergic precursors have represented the first approach to counter cognitive impairment occurring in adultonset dementia disorders. In preclinical studies choline alphoscerate increases the release of acetylcholine in rat hippocampus, facilitates learning and memory in experimental animals, …
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Investigating the Influence of Upper Limb Movements on Lower Limb Neuroplasticity in Humans
… of upper limb (UL) movements on lower limb (LL) neuroplasticity in humans, with a focus on both healthy individuals and those with chronic stroke. Using neurophysiological tools to assess spinal and cortical excitability, the studies examined whether UL activity modulates LL neuromotor function …
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Face Motor Cortex Neuroplasticity Associated with Alterations in the Oral Environment of the Adult Rat
Neuroplastic changes in motor representations within the primary motor cortex (M1) have been described after peripheral manipulations and implicated in motor learning and adaptation processes. It is unclear whether dental manipulations, which may result in altered oral sensorimotor functions, are …
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Vulnerability and Resilience to Social Defeat: The Role of Neuroplasticity Within the Mesolimbic Dopamine Circuit
The pathophysiology of major depression and post-traumatic stress disorder are poorly understood. In particular, while stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The molecular mechanisms …
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Transcriptional response to spatial learning and foraging in honey bees: molecular bases for adult neuroplasticity
… molecular processes that enable persistent neuroplasticity in the adult and aging brain. In many species, some types of neuroplasticity typically decrease with age. Honey bees and other social hymenopterans, however, exhibit a reinstatement of structural plasticity in association with flight …
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Investigations on the role of the gut microbiota in hippocampal neuroplasticity and behaviour throughout the lifespan
… been shown to harness the ability to influence neuroplasticity within the hippocampus of the brain, as well as hippocampus-dependent behavioural processes. The hippocampus is one of the few brain regions in which new neurons are born throughout life, an ability that is critical for specific …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… addresses two separate targets to modulate neuroplasticity. In Chapter 2, the TrkB receptor as a potential target for pharmacological modulation is examined. Its signaling, role in brain disease, and reported agonists and antagonists are reviewed. In addition, our attempts at establishing an …
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Neuroplasticity and chronic low back pain: an investigation into altered tactile discrimination, body schema and motor function.
Chronic low back pain (CLBP) ranks 3rd in the Global Burden of Non-Communicable Diseases, behind heart disease and stroke and the problem is increasing with an aging and growing population. It is a painful, long-term condition contributing to increased morbidity, low quality-of-life and a …
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Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity
Hemiplegic cerebral palsy is characterized by unilateral upper limb impairment and patients often compensate by performing most tasks with their unaffected arm. Constraint-induced movement therapy (CIMT) directly combats this learned non-use by casting the unaffected arm and forcing the patient to …
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Investigation of non-traditional roles of the neural gut-brain axis
… Just as nutrients have been shown to induce neuroplasticity of CNS neurons, long-term alterations in nutrition may do more than just change signaling, and ultimately lead to modifications in fiber density, branching, and terminal morphology. These neuroplastic changes may underlie aberrant …
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Cortical location of saccadic and vergence oculomotor learning using fMRI
… of a species and changes throughout life via neuroplasticity. The brain receives most of its information about the external world via the visual system. Eye movements are used to direct the visual information of interest to the fovea, the area of the retina which has the highest density of …
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An Investigation of the Effect of Chronic Unpredictable Stress on Hippocampal Integrity and Spatial Learning
… chronic unpredictable stress (CUS), markers of neuroplasticity were preserved specifically in the dorsal dentate gyrus (DG) of the hippocampus. Considering that hippocampal integrity is imperative for learning and memory, we hypothesized that the increased markers of neuroplasticity observed in …
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Electrophysiological Markers of Sensory Plasticity and Connectomics in Ageing and Mild Cognitive Impairment
… insight into disease-specific disruptions of neuroplasticity that have immense implications for biomarker and intervention development. The aims of this thesis were to 1) investigate the brain's learning mechanisms using electroencephalography (EEG) and Dynamic Causal Modelling (DCM) and 2) …
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Mechanisms by which exercise promotes cognitive function in both depressed and non-depressed individuals
… in biochemical markers associated with neuroplasticity. Less than half of MDD patients receive an efficacious treatment, warranting the need for novel treatment strategies. Exercise as an add-on therapy is a promising approach shown to improve mood, however, its mechanism of action …
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The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
… (IL 6 and IL-8) and oxidative stress in vitro. Neuroplasticity proteins and antioxidant system were also perturbed by lopinavir/ritonavir treatment in mice brain which were prevented by the pretreatment with sulforaphane. In the first chapter, we investigate the effect of Vpr on the induction of …
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