Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"neuropilin-1"”.
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The Role of Semaphorin-Neuropilin-1 Signalling in Pulmonary Vascular Development
… that orchestrate normal parenchymal development. Neuropilin-1 (NRP1) is a transmembrane receptor that plays essential roles in normal and pathological vascular development, and binds two distinct ligand families: Vascular endothelial growth factor (VEGF) and Class 3 Semaphorins (SEMA3). Although …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… with Matrix Metalloproteinase-2 (MMP-2) and Neuropilin-1 (NRP-1) being the most studied candidates. Previous studies have identified the C-terminal region of Ctx as critical for inhibiting GBM cell migration. To explore this further, we designed C-terminal peptide fragments of Ctx with …
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Rational Identification of Neuropilin-1 Inhibitors: From Deep-Learning to Drug Repurposing
Neuropilins (NRP)—comprising neuropilin-1 (NRP1) and neuropilin-2 (NRP2)—are type I transmembrane glycoproteins with multifunctional extracellular regions. NRP1 functions as a multifunctional, non-enzymatic co-receptor that potentiates signalling from vascular endothelial growth factor (VEGF), …
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Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
… upregulation of VEGFR2 and enhancement in VEGFR2-neuropilin-1 interactions. Here, I show that tumour growth and angiogenesis are sensitive to neuropilin-1 perturbation even with only a 50% reduction in β3-integrin expression. β3-integrin-heterozygous, but not wild-type, mice show an increased …
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Targeting epithelial senescence to augment renal repair
… Disulfide Isomerase Family A Member 3 and Neuropilin-1 attenuate post injury fibrosis in vivo.
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… system. Recently, guidance cue receptors DCC, Neuropilin-1 and Robo2 were shown to interact with the translation machinery. Both the protein and mRNA interactions of these receptors help them to define which proteins are locally synthesized in response to stimulation. BDNF likewise regulates …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… and the perlecan-semaphorin 3A-plexin A1-neuropilin-1 (PSPN) complex) and translates this knowledge into viable solutions for both tissue engineering and cancer metastasis applications. Database (Matrisome/FANTOM5) and two-dimensional and three-dimensional cell culture analysis identified …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… activates a holoreceptor complex composed of neuropilin-1 (NRP1) / PlexinA4 (PLXNA4), leading to changes in cytoskeletal architecture by way of altering collapsin response mediator protein 2 (CRMP2). Sema3A signaling has been studied extensively in the developing nervous system, though much …
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Targeting nucleic acids for pancreatic cancer: disease modeling and therapy
… with [alpha][upsilon][beta]3/5 integrins and neuropilin-1, we hypothesized that "tandem" peptides combining a cell-penetrating peptide and iRGD can complex with siRNA to form tumor-penetrating nanocomplexes (TPNs) effective in delivering siRNA to PDAC. Such a nanoscale carrier could provide a …
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Development and application of optical microscopy tools for the study of axon guidance
… receptors deleted in colorectal cancer (DCC) and neuropilin-1 (Nrp1) with the translation machinery. This interaction was found to be mediated through RNA binding proteins (RBPs), enabling a receptor-specific mRNA subset to be rapidly and locally translated in response to cue stimulation. Further …
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
… used as a receptor for viral entry, we identify neuropilin-1 (NRP-1) as a factor facilitating viral entry into these neurons. As the COVID-19 pandemic progressed, numerous variants of SARS-CoV-2 emerged, calling into question the impact of viral variants on the neuroinvasive potential of these …
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The Role of Twist2 in Physiologic and Pathologic Myogenesis
The file named "LI-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.