Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"neuropilin"”.
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The Role of Semaphorin-Neuropilin-1 Signalling in Pulmonary Vascular Development
… that orchestrate normal parenchymal development. Neuropilin-1 (NRP1) is a transmembrane receptor that plays essential roles in normal and pathological vascular development, and binds two distinct ligand families: Vascular endothelial growth factor (VEGF) and Class 3 Semaphorins (SEMA3). Although …
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Quantitative analysis of neuropilin-2 expression in pigmented lesions and melanoma
… of a primary melanoma and ultimately metastasis. Neuropilins, specifically Neuropilin-2 (NRP2), have been found to be associated with both angiogenesis and lymphangiogenesis and thus metastasis. Since it is critical to identify and treat melanoma before it advances to metastasis, the relationship …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… with Matrix Metalloproteinase-2 (MMP-2) and Neuropilin-1 (NRP-1) being the most studied candidates. Previous studies have identified the C-terminal region of Ctx as critical for inhibiting GBM cell migration. To explore this further, we designed C-terminal peptide fragments of Ctx with …
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Rational Identification of Neuropilin-1 Inhibitors: From Deep-Learning to Drug Repurposing
Neuropilins (NRP)—comprising neuropilin-1 (NRP1) and neuropilin-2 (NRP2)—are type I transmembrane glycoproteins with multifunctional extracellular regions. NRP1 functions as a multifunctional, non-enzymatic co-receptor that potentiates signalling from vascular endothelial growth factor (VEGF), …
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Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
… upregulation of VEGFR2 and enhancement in VEGFR2-neuropilin-1 interactions. Here, I show that tumour growth and angiogenesis are sensitive to neuropilin-1 perturbation even with only a 50% reduction in β3-integrin expression. β3-integrin-heterozygous, but not wild-type, mice show an increased …
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Prognostic and Predictive Factors in Renal Cell Carcinoma /// Прогностични и предиктивни фактори при бъбречноклетъчен карцином
… е изследвана имунохистохимичната експресия на Neuropilin и YAP. Neuropilin има роля на ко-рецептор при свързването на VEGF и неговите рецептори и така участва в процеса на ангиогенеза. Освен в ендотелните клетки той се експресира още и при клетки на имунната система и епителни клетки-бенигнени …
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Targeting epithelial senescence to augment renal repair
… Disulfide Isomerase Family A Member 3 and Neuropilin-1 attenuate post injury fibrosis in vivo.
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… system. Recently, guidance cue receptors DCC, Neuropilin-1 and Robo2 were shown to interact with the translation machinery. Both the protein and mRNA interactions of these receptors help them to define which proteins are locally synthesized in response to stimulation. BDNF likewise regulates …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… and the perlecan-semaphorin 3A-plexin A1-neuropilin-1 (PSPN) complex) and translates this knowledge into viable solutions for both tissue engineering and cancer metastasis applications. Database (Matrisome/FANTOM5) and two-dimensional and three-dimensional cell culture analysis identified …
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Halting the neural progression of cancer
Neuropilin (NRP) receptors have functions in axonal guidance and neuronal patterning. Class 3 semaphorin (SEMA3) molecules act as inhibitors of NRP receptors by preventing the activation of downstream signaling pathways involved in cytoskeletal organization and migration. Tumor-associated …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… activates a holoreceptor complex composed of neuropilin-1 (NRP1) / PlexinA4 (PLXNA4), leading to changes in cytoskeletal architecture by way of altering collapsin response mediator protein 2 (CRMP2). Sema3A signaling has been studied extensively in the developing nervous system, though much …
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Paxillin-dependent control of tumor angiogenesis
… decreases expression of the VEGF receptor neuropilin 2 (NRP2) but not VEGF receptor 2, and this is mediated by the transcription factor GATA2. Direct knockdown of NRP2 also increases endothelial cell migration and vessel density in vitro and in vivo and these effects are rescued by over …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… VEGF signalling via competition for the neuropilin co-receptors. Furthermore, SEMA3G was shown to prevent pathological vascular remodelling in diabetic and oxygen-induced retinopathies. These findings suggest that SEMA3G could play an important role in maintaining the stability and …
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Targeting nucleic acids for pancreatic cancer: disease modeling and therapy
… with [alpha][upsilon][beta]3/5 integrins and neuropilin-1, we hypothesized that "tandem" peptides combining a cell-penetrating peptide and iRGD can complex with siRNA to form tumor-penetrating nanocomplexes (TPNs) effective in delivering siRNA to PDAC. Such a nanoscale carrier could provide a …
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Development and application of optical microscopy tools for the study of axon guidance
… receptors deleted in colorectal cancer (DCC) and neuropilin-1 (Nrp1) with the translation machinery. This interaction was found to be mediated through RNA binding proteins (RBPs), enabling a receptor-specific mRNA subset to be rapidly and locally translated in response to cue stimulation. Further …
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Synthesis, surface modifications and biomedical applications of colloidal gold nanoparticles, towards controlled regulation of angiogenesis in conjunction with photo-thermal therapy
… growth factor receptor type 1 (VEGFR-1) and neuropilin receptor type 1 (NRP-1). Both, VEGFR-1 and NRP-1 were targeted with peptide functionalised NPs. Selectivity of the binding was investigated. Following the binding event, physiological changes in cell metabolism were triggered. The nature …
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
… used as a receptor for viral entry, we identify neuropilin-1 (NRP-1) as a factor facilitating viral entry into these neurons. As the COVID-19 pandemic progressed, numerous variants of SARS-CoV-2 emerged, calling into question the impact of viral variants on the neuroinvasive potential of these …
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The Role of Twist2 in Physiologic and Pathologic Myogenesis
The file named "LI-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.