Global ETD Search
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Showing 1 to 6 of 6 for “"neuropeptidomics"”.
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Neuropeptidomics Across Metazoan Life
Every neuron in our brain is bathed in a sea of diverse signaling molecules, including peptides. It is well known that neuropeptides, acting as neurotransmitters, neuromodulators and peptide hormones, play pivotal roles in a variety of physiological processes, such as learning and memory, sleeping, …
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Neuropeptidomics: MS-base peptide identification and quantitation study
Neuropeptidomics refers to a global characterization approach for the investigation of neuropeptides, often under specific physiological conditions. Neuropeptides comprise a complex set of cell-to-cell signaling molecules that are important in regulatory functions and behavior in the nervous …
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Analysis of D-amino acid-containing neuropeptides in mollusks and rodents
Modern mass spectrometry (MS)-based neuropeptidomics continues to reveal an unprecedented level of chemical complexity in the nervous system on the peptide level, with sometimes hundreds of peptides expressed by or secreted onto specific structures. These neuropeptides have evolved for animal …
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… for mass spectrometric analysis. Here, the neuropeptidomics study of the SON resulted in the identification of 85 peptides, including 20 unique peptides from known prohormones. This study includes mass spectrometric analysis even from individually isolated magnocellular neuroendocrine cells, …
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Liquid chromatography and mass spectrometry based characterization to understand the role of neuropeptides in various physiological conditions and disease states
Neuropeptides are the largest and most diverse class of cell-cell signaling molecules in the brain. They are expressed and synthesized by neurons and endocrine organs, released upon stimulation and act by binding to specific cell surface receptors that initiate a cascade of downstream signaling …
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Liquid chromatography-mass spectrometry-based neuropeptide characterizations across neuronal models
Neuropeptides, as one largest category of cell-to-cell signaling molecules, play a regulatory role in a range of physiological and behavioral functions within an organism, such as reproduction, feeding, metabolism regulation, learning and memory. They act as neurotransmitters,neuromodulators, …