Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"neuropeptides"”.
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Measurement of neuropeptides: From presence to release
Characterization of neuropeptides is still actively underway. Various resources, both animal and instrument, were utilized to best answer the questions about the presence of peptides. Aplysia californica cerebral neurons were used to verify predicted peptide processing of the putative prohormone …
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Investigating the role of neuropeptides in plant parasitic nematodes
… transgenic Bacillus subtilis to deliver PPN<br/>neuropeptides in a tomato seedling invasion assay identified several neuropeptides which induce aberrant behaviours in Meloidogyne incognita and Globodera pallida conferring resistance to tomato seedlings. This thesis demonstrated Bacillus subtilis …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential …
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From Prohormones to Neuropeptides: Mass Spectrometric and Bioinformatic Approaches
… and mass spectrometric approaches, the neuropeptides are predicted with the Aplysia-based algorithms. To verify all predictions, the peptide sequences are confirmed by electrospray quadrupole mass spectrometry (ESI-Q) TOF-MS. Employing information from additional species will help to …
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Characterization of D-amino acid-containing neuropeptides from metazoa
… been found in this list; and in several cases, neuropeptides, a group of cell-to-cell signaling molecules found in the neural tissues, were also shown to undergo such modifications. DAACPs are distributed across different species in several animal phyla, Arthropoda, Mollusca, and Chordata, …
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Characterization and spatial mapping of isomerized residues in neuropeptides
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Analysis of D-amino acid-containing neuropeptides in mollusks and rodents
… by or secreted onto specific structures. These neuropeptides have evolved for animal behaviors and regulating neuronal circuits. Neuropeptides exert their responses through GPCRs in most cases, and in order to interact with the GPCR, their structure is important. Their structures are not solely …
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The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
… area, opening the possibility that these LH neuropeptides could be involved in feeding behavior and drug addiction. This study shows that orexin neurons, and not the nearby LH neurons expressing MCH have 歯pioid receptors and respond with induction of cFos and CRE- mediated transcription to …
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Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
Other PTMs, such as the transformation of L-amino acid residues to the D-configuration, do not result in a measurable mass change. Capillary electrophoresis combined with mass spectrometry is used to identify cells containing a D-amino acid-containing peptide found in Aplysia. These cells are then …
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The Allatoregulatory Neuropeptides and their Genes in the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)
… the hypothesis that “allatoregulating” neuropeptides are diverse in structure, widely distributed and exhibit multiple functions. The functions may be tissue-specific as well as specific to particular developmental stages of insects. Knowledge of the various peptide precursor sequences …
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Characterization of RYamide neuropeptides and their Receptor in the Disease Vector Mosquito, Aedes aegypti
Insects utilize neuropeptides to fine-tune their physiological systems, including the tissues and organs involved in excretion, respiration, reproduction, and metabolism. The focus of this study is on the recently identified RYamide insect neuropeptides, named for the arginine-tyrosine amidated …
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Neuropeptides Amplify and Focus the Monoaminergic Inhibition of Nociception in <i>Caenorhabditis elegans</i>
… monoamines, including OA and dopamine (DA), and neuropeptides from an array of additional neurons. For example, TYRA-3 stimulates the release of neuropeptides encoded by <i>nlp- 1</i>, <i>nlp-14</i> and <i>nlp-18</i> from axons of the two ASI sensory neurons and both Gα<sub>q</sub> and …
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Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin
… called neurotrophic factors. There are also neuropeptides, which are involved in signaling between brain cells. Both neurotrophic factors and neuropeptides have been shown to have an important role in suppressing epileptic activity. In this thesis, we focused on one neurotrophic factor and …
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Evaluation of database search programs for accurate detection of neuropeptides in tandem mass spectrometry experiments
… experiments are not optimized to identify neuropeptides and other peptides resulting from the processing of prohormones. This is due to the unique characteristics of neuropeptides including release after complex processing of prohormones, potentially intense post-translational modifications …
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Sampling Strategies for Characterization of Neuropeptides Using Mass Spectrometry and Functional Implications Into Cell -Cell Signaling
The peptides with roles in the development of the pituitary were analyzed using transgenic mice. Hes1 KO is a genetically modified mouse that lives only e18.5 (embryonic days). Anterior pituitaries of Hes1 null mice exhibit hypoplasia due to increased cell death and reduced proliferation and in the …
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… cell culture served as the main model to study neuropeptides, in addition to hippocampal neurons and mouse embryonic pituitaries. The neuropeptidomcis studies described here use different extraction methods on tissue or cell culture combined with mass spectrometry (MS) techniques, …
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Secondary structure determination of insect neuropeptides using high-resolution nuclear magnetic resonance and various molecular mechanics calculations
Insect neuropeptides play a vital role in the hormone release processes associated with insect flight Elucidation of the metabolic flight pathways requires a knowledge of the peptide secondary structure to allow predictions to be made regarding hormone-receptor binding processes. The three insect …
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Distribution of neuropeptides and neurotransmitters and their effects on insulin and glucagon secretion in normal and diabetic rat pancreas
… is available in the literature about the role of neuropeptides and neurotransmitters in the control of insulin and glucagon secretion from diabetic pancreatic tissues. The aim of this study is to investigate the role of the neuropeptides: vasoactive intestinal polypeptide (VIP), neuropeptide Y …
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