Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"neuropeptide signaling"”.
-
Cloning and Characterization of the Vasopressin-Oxytocin Neuropeptide Signaling System in the Vocal Control System of the Zebra Finch (Taeniopygia guttata)
<p>Vasopressin (VP) and Oxytocin (OT) are neuropeptides produced in the hypothalamus and expressed in the cerebrum and pituitary gland of the brain. Studies of VP and OT have long demonstrated their influence on social behaviors in mammals. Comparative analyses of these neuropeptides and in-depth …
-
Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… UNC-73 RhoGEF2 containing isoforms and the Rho signaling pathway in the adult nervous system of C. elegans.Animals with mutations in the unc-73 RhoGEF2 domain move more slowly than wild-type animals and this locomotory defect can be rescued by pan-neuronal expression of the UNC-73E isoform, …
-
The Roles of the Neuropeptide Receptor NPR-14 in the Regulation of Sleep Behaviours in Caenorhabditis elegans
… neuronal pathways and utilizes a variety of neuropeptide signaling molecules. The DTS pathway uses the expression of the neuropeptide gene nlp-22 and that of the SIS pathway uses the neuropeptide flp-13. Our lab has discovered a neuropeptide receptor gene called npr-14 that, when mutated, …
-
Measurement of neuropeptides: From presence to release
Characterization of neuropeptides is still actively underway. Various resources, both animal and instrument, were utilized to best answer the questions about the presence of peptides. Aplysia californica cerebral neurons were used to verify predicted peptide processing of the putative prohormone …
-
Identification of Gene Expression Changes in Sleep Mutants Associated With Reduced Longevity in Drosophila
… scope of this study, I focused on candidate gene Neuropeptide-like precursor 3 (Nplp3), a putative neuropeptide precursor. RNA sequencing results revealed that expression levels of Nplp3 were reduced in sleep mutants and aged wild type animals, compared to control flies. These results were …
-
Transcriptional profiling of Drosophila larval ventral nervous system hemilineages
… genes not expressed in immature neurons, such as neuropeptide signaling genes and many neurotransmitter and ion channel genes associated with mature neuron function. Birth order also appears to dictate many differences in expression profile. Late-born immature neurons are typified by a period of …
-
The Neural Circuit for Behavioral Responses to Pheromone and Social Behavior in Caenorhabditis Elegans
… behavior. Animals with null mutation in the neuropeptide receptor npr-1 have reduced avoidance of ascr#3/C9. I found that this effect is mediated by ADL participation in a gap junction circuit with the "social" hub interneuron RMG. Thus ADL chemical synapses and ADL gap junctions appear to …
-
The Neuropeptide Regulation of Host-Seeking Behavior in Aedes Aegypti Mosquitoes
… studies identified Head Peptide-I as a candidate neuropeptide modulating this suppression in host-seeking behavior. This conclusion was strengthened by the observation that Head Peptide-I injection into non-blood-fed females triggered the inhibition of host-seeking. The mechanism by which this …
-
Mass spectrometry-based characterization of cell-to-cell signaling molecules in the nervous system
Cell-to-cell signaling molecules are an important class of endogenous molecules which are responsible for cell-to-cell communication within organisms. Small molecules and peptides work as neurotransmitters and neuromodulators in the nervous system and play important regulatory roles in a wide range …