Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"neuropeptide Y (NPY)"”.
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Exploring relationships between stress and olfaction as mediated by neuropeptide y
… and resilience to stress, specifically examining neuropeptide y (NPY) as a mediator. In phase I, 197 UTC students participated in a survey measuring stress and resilience among other factors. Of this sample, 25 students volunteered for phase II, in which they took an olfactory threshold test and …
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The pharmacological inhibition of the neuropeptide Y1 and Y5 receptors on proliferation, migration, and cell signaling in hypoxic breast carcinomas
Neuropeptide Y (NPY) has been linked to the initiation and progression of breast cancer. NPY activates six G-protein coupled receptors (GPCRs) in breast cancer, of which, NPY1R and NPY5R are the most biologically significant. Activation of these receptors by peptide binding impacts tumour …
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Effects of Neuropeptide Y on Adipocyte Metabolism
Recently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose tissue of an early-life programmed rat model of central obesity. Moreover, we have demonstrated that NPY contributes to the pathogenesis of obesity. However, the role of NPY in regulating adipocyte …
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Appetite Regulatory Neural Circuitry in the Prenatal Testosterone Treated and Obese Ewe
… express both agouti-related protein (AgRP) and neuropeptide Y (NPY), or proopiomelanocortin (POMC) and cocaine- and amphetamine- regulated transcript (CART). We then asked whether this circuitry is altered in ewes at increased risk of obesity following prenatal testosterone (T) treatment, or in …
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Central mechanisms of prolactin-releasing peptides orexigenic effect in chickens
… peptide (PrRP) is an endogenous hypothalamic neuropeptide that when exogenously injected increases food intake in chickens, but decreases it in rodents and goldfish. We designed three sets of experiments to elucidate the mechanisms of PrRP's orexigenic effect in chicks. In experiment one, food …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
… joint (TMJ) inflammation and pain transmission. Neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and their receptors have been implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate activation of NPY, VIP, and their …
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Folding, dynamics and interaction studies of the Neuropeptide Y family.
… advance the treatment of human disease. The Neuropeptide Y family of peptides are highly conserved peptides found in nature, consist of 36 amino acids, and are widely distributed in the central nervous system of mammals. A detailed study of thermodynamics, kinetics, membrane translocation, …
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Changes in NPY staining in the arcuate nucleus during and after food restriction in lactating rats
… investigated the effects of food restriction on Neuropeptide Y (NPY) staining in the arcuate nucleus of lactating rats to evaluate a role for NPY in the maintenance of lactational diestrus in food restricted rats. NPY staining was compared on days 15, 20 and 25 of lactation between animals fed ad …
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Role of appetite-regulating peptides in adipose physiology in broiler chicks
… collectively known as the "brain-fat axis". Neuropeptide Y (NPY) is orexigenic and promotes adipogenesis in both birds and mammals, although mechanisms in adipose tissue are unclear. The first objective was thus to evaluate effects of NPY on chick preadipocyte proliferation and …
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Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus
Neuropeptide Y (NPY)-expressing neurons in the arcuate nucleus of the hypothalamus are part of a neuroendocrine feedback loop that regulates feeding behavior and glucose homeostasis. NPY neurons sense peripheral signals of energy stores, including the hormones leptin, insulin, and ghrelin, and …
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Investigating the Role of Neuropeptide Y in the Ventral Hippocampus in Regulating Rats’ Elevated Plus-Maze and Shock-Probe Burying Behaviours
Neuropeptide Y (NPY) has recently gained interest as a potential regulator of anxiety-like behaviours. However, its anxiety-associated effects in the ventral hippocampus are not well known, even though this structure is also heavily implicated in anxiety regulation. The goal of this thesis was to …
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Innervation des Cervidenhodens
… (DBH) activity, mostly co-expressed with neuropeptide Y (NPY). There are only a few cholinergic nerves in the cervine testis. Myelinated fibres occurr in the spermatic cord and the tunica albuginea as shown by Myelin-Basic-Protein (MBP)-immunreaction and are regarded as afferent. The …
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ΑΝΟΣΟΚΥΤΤΑΡΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΤΟΥ ΑΓΓΕΙΟΚΙΝΗΤΙΚΟΥ ΠΟΛΥΠΕΠΤΙΔΙΟΥ ΤΟΥ ΕΝΤΕΡΟΥ, ΤΗΣ ΧΟΛΗΚΥΣΤΟΚΙΝΙΝΗΣ ΚΑΙ ΤΟΥ ΝΕΥΡΟΠΕΠΤΙΔΙΟΥ Υ ΣΤΟ ΚΕΝΤΡΙΚΟ ΝΕΥΡΙΚΟ ΣΥΣΤΗΜΑ, ΤΟΥ ΣΚΑΝΤΖΟΧΟΙΡΟΥ ΚΑΙ ΤΟΥ ΠΡΟΒΑΤΟΥ
… POLYPEPTIDE (VIP)-, CHOLECYSTOKININ (CCK)- AND NEUROPEPTIDE Y (NPY)- CONTAINING NEURONS IN THE CNS OF THE HEDGEHOG AND SHEEP, WERE INVESTIGATED USING AN IMMUNOCYTOCHEMICAL METHOD. A TOTAL OF THIRTY-TWO HEDGEHOGS AND TWENTY-FOUR SHEEP OF BOTH SEXES WERE USED. FROZEN CORONAL SECTIONS OF THE BRAIN …
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Mechanisms associated with secretory and contractile responses in tissues and cells of the body in health and disease
… (ACh), noradrenaline (NA), or a number of neuropeptides (vasoactive intestinal peptide (VIP), substance P, neuropeptide Y (NPY) and several others), can elicit protein and enzyme secretion. Apart from nervous control, exocrine pancreatic secretion is regulated by both endocrine and …
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Dietary macronutrient composition and exogenous neuropeptide Y affect feed intake in brioler chicks
… States. Central appetite regulators, known as neuropeptides, are pivotal in understanding appetite regulation. Neuropeptide Y (NPY), a 36 amino acid peptide, plays a major role in regulating the hunger signals from the brain. In all vertebrates studied, it is a strong orexigenic …
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… In these investigations, I examined changes in neuropeptides and a catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), following middle cerebral artery occlusion (MCAO) in adult male Wistar rats.;Five days following MCAO, the immunoreactivity for TH and neuropeptide Y (NPY) increased …
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Modulation of Neutrophil Functions by Neurotransmitters Implicated in Stress
… levels of catecholamines while plasma levels of neuropeptide Y (NPY) are significantly increased. Sympathetic nerve fibers with NPY have been found to innervate immune organs. It was hypothesized that NPY might be a mediator in immune modulation in people under chronic stress. Human neutrophils …
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Involvement of AMP-activated protein kinase in differential regulation of appetite between lines of chickens selected for low or high juvenile body weight
… I (CPT1), leptin receptor (LEPR) and neuropeptide Y (NPY) and less mRNA expression of ACC α, fatty acid synthase (FAS), fat mass and obesity associated gene (FTO), pro-opiomelanocortin (POMC) and orexin in LWS than HWS chickens. At 5 days of age, intracerebroventricular (ICV) injection …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
… for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. The neuropeptide Y (NPY) may represent one such target, as it plays a key role in controlling excitability in the hippocampus by suppressing glutamatergic transmission. …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… (BIII tubulin (B3T), synaptophysin (SYN), neuropeptide Y (NPY), tyrosine hydroxylase (TH)) and EES markers (Chromogranin A (CoA), somatostatin (SOM), serotonin (SER), NPY, Neurotensin (NeuroT)) were used to assess the development of the ENS and enteroendocrine cells (EECs), respectively. At …
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