Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 131 for “"neuropathology"”.
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Neuropathology and sensitivity in the keratoconic cornea
Corneal touch threshold (CTT) was investigated by aesthesiometry in patients with keratoconusq with and without contact lens wear. Using a matching control group it was established that CTT was significantly higher for the central corneal position in keratoconus. No difference inCTT was found in …
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Diagnostic Neuropathology of Brain Tumours using Biophotonics and Spectrometry
… the potential to be used as diagnostic tools in neuropathology. They provide an intrinsic molecular fingerprint of the sample based on the interaction of light. The panels can accurately identify and classify specific brain tumours alleviating the need to use complex statistical models. Raman and …
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CHROMATIN DISRUPTION IN HUNTINGTON'S DISEASE ALTERS DEVELOPMENT AND PRECEDES NEUROPATHOLOGY
La Corea di Huntington (MH) è una malattia neurodegenerativa causata da un’espansione del tratto CAG nel gene Huntingtina (HTT), che porta alla formazione di un tratto di glutammine eccessivamente lungo nell’HTT mutata (mHTT). Sebbene la manifestazione clinica si osservi generalmente in età …
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The Effects and Mechanisms of Phytochemicals on Alzheimer’s Disease Neuropathology
… consumed phytochemicals on Alzheimer’s disease neuropathology and outcomes. The data suggest that regular consumption of bioactive phytochemicals from a variety of fruits and vegetables attenuates age- and insult-related Alzheimer’s disease neuropathology.</p>
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Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology
Alzheimer’s Disease (AD) is a multifactorial neurodegenerative dementia with no curative therapeutic options. One of the earliest impairments in AD triggering cognitive decline is the synaptic dysfunction induced by the selective targeting and interruption of the synaptic region by the small …
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Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
… the non-demented humans with Alzheimer’s Disease neuropathology, and that this change is in part due to deregulation of the miRNA activity in the neurogenic niche. Further, the investigated mouse model appears promising as an atypical model for Alzheimer’s for its tendency toward recapitulating …
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Characterizing and Treating The Neuropathology of Tuberous Sclerosis Complex In The Mouse
… mouse as an excellent model for the study of the neuropathology of TSC and testing novel therapies. We further describe the use of this mouse model to assess the therapeutic potential of the macrolide rapamycin, an inhibitor of mTORC1. We demonstrate that rapamycin administered from postnatal day …
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Speech Network Regional Differences in Bulbar Amyotrophic Lateral Sclerosis: Neuroimaging and Neuropathology Investigations
… systematically reviewed and compared published neuropathology data between bulbar-onset ALS (bALS) and spinal-onset ALS (sALS) in order to distinguish bulbar from spinal ALS. Neuropathology in IFG and pSTG were variable in bALS cases, however consistently spared in sALS. A subset of bALS cases …
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The role of the immune system in Parkinson’s Disease: from neuropathology to treatment.
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterised by progressive loss of dopaminergic neurons (DAn) in the substantia nigra. In the first part of this thesis (chapters 3-4) I describe the immune characterisation of a human embryonic stem cell (hESC)-derived dopamine …
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State-space Modeling of Neural Oscillations: Toward Assessing Alzheimer’s Disease Neuropathology with Sleep EEG
… to assess neural activity impacted by AD neuropathology before clinical symptoms emerge. However, many existing practices in sleep electroencephalography (EEG) analysis are based on visual inspection and the ubiquitous Fourier transform. These approaches face several methodological …
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The Effect of Chronic Hypertension on Neuropathology in the TGSWDI Mouse Model of Alzheimer's Disease
<p>Numerous epidemiological studies link vascular disorders, such as hypertension, diabetes and stroke, with Alzheimer's disease. Hypertension, specifically, is an important modifiable risk factor for late onset Alzheimer's disease. Despite the abundance of clinical data connecting these …
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Modeling of FUS- and C9ORF72-associated cortical neuropathology using patient-specific induced pluripotent stem cells
Amyotrophe Lateralsklerose (ALS) ist eine neurodegenerative Erkrankung, bei welcher speziell erste (kortikospinal) und zweite (spinal) Motorneurone (MN) von Neurodegeneration betroffen sind. Gegenwärtig bleibt ALS eine unheilbare Erkrankung. Der Tod tritt durchschnittlich 2 bis 5 Jahre nach …
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The Genetic Basis Of Neurodegenerative Diseases: The Role Of Sel1L In Tau Pathology And Neuropathology
Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the selective loss of subsets of neurons in the central nervous system (CNS). While increasing evidence suggests a combination of both genetic and environmental factors as the cause of …
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Diazepam administration during acute thiamine deficiency attenuates subsequent neuropathology and spatial-memory deficits in rats
… only at the 120-sec delay. Moreover, thalamic neuropathology was attenuated in the PTD+DZ rats. Although further studies will be needed to determine the mechanism by which diazepam exerts its protective effects in this model, the present study suggests that PTD-induced neuropathology and memory …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
Schizophrenia is a debilitating, life-long illness with a still-unknown, complex etiology and, currently, no cure. Many studies have implicated the hippocampus and the parahippocampal region as a place of both primary pathology in the disease and as regions correlated to symptom severity. To better …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
Better than 90% of AIDS patients have neuropathology identified at autopsy. HIV-1, the causative organism of AIDS, produces neuronal death as a primary viral effect in many AIDS cases, and it does so even though the virus does not infect neurons. The search for the pathomechanisms by which HIV-1 …
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Patterns of cognitive impairment in multiple sclerosis and their relationship to neuropathology on magnetic resonance imaging
… Due to the disseminated distribution of MS neuropathology, patients may undergo idiosyncratic cognitive changes dependent upon the site of white matter lesions. The present study explored this question using cluster analysis on the neuropsychological data from a group of mildly disabled MS …
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Gender differences in risk of neuropathology, cognitive decline and dementia in the Cognitive Function and Ageing Study (CFAS)
… a systematic analysis of gender differences in neuropathology, and consideration of cardiovascular risk factors and cognitive reserve. The effects of dropout and death on estimates of gender differences in cognitive decline were explored using subject-specific and population-average statistical …
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Non invasive brain stimulation : modeling and experimental analysis of transcranial magnetic stimulations and transcranial DC stimulation as a modality for neuropathology treatment
… DC Stimulation (tDCS) as modalities for neuropathology treatment by means of both experimental and modeling paradigms. The first and primary modality that will be analyzed is Transcranial Magnetic Stimulation (TMS). TMS is a technique that uses the principle of electromagnetic induction …
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