Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"neuropathogenesis"”.
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
<p>Background. GM1-ganglisidosis is a rare neurodegenerative lysosomal storage disease caused by the deficiency of the lysosomal enzyme β-GAL, resulting in the accumulation of its target substrate GM1. GM1, a glycosphingolipid found primarily in the PM of neurons, is known to modulate Ca2+ flux …
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The Neuroprotective Effects of Exercise Against Menopause Induced Alterations in Alzheimer’s Disease Neuropathogenesis
<p>Alzheimer’s Disease (AD) disproportionately impacts women; and the loss of ovarian hormones during the perimenopausal transition has been identified as a sex-specific risk factor. Previous studies have shown that the ovarian hormone, estrogen, utilizes its neuroprotective effects on tissues in …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… cytokines, each of which is implicated in HAND neuropathogenesis. The increased immune activation and oxidative stress detected in blood and CSF of ART-treated individuals suggests that these processes could be targeted for neuroprotection. Accordingly, we previously identified a correlation …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… its protective functions may contribute to HIV neuropathogenesis. Moreover, this work defines a predictable and conserved relationship between HIV replication, HO-1 loss, and neurotoxin production in macrophages that likely reflects processes in place in the HIV-infected brain of individuals …
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Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations and Identification of Novel Host Barriers to Poliovirus Neuropathogenesis
Neurotropic viruses comprise some of the worlds most widespread and deadly pathogens, including West Nile virus, rabies virus, and poliovirus. Poliovirus, as a model neurotropic virus, is also an RNA virus. RNA viruses have high mutation rates and a propensity to revert attenuating mutations, …
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
During the COVID-19 pandemic, reports of neurological symptoms affecting the central nervous system (CNS) and peripheral nervous system (PNS) became common, suggesting the virus may be neuroinvasive. These observations prompted studies to determine how SARS-CoV-2, the causative virus, invades the …
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The role of gylcoprotein K (gK) in the ocular and neuropathogenesis of herpes simplex virus-type 1 (HSV-1)
<p>Herpes simplex virus type 1 (HSV-1) is a DNA virus that is a ubiquitous pathogen of humans. The hallmark of the HSV-lifecycle is infection of a mucosal surface with spread to sensory neurons where the virus establishes a latent infection with periodic recurrences for the life of the host. The …
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Hybrid Brain-Tissue Based Model to Study the Role of Infiltrating Monocytes in Late Stage Huntington's Disease
… and late-onset neurodegenerative disorder. Its neuropathogenesis is characterized by selective loss of medium spiny neurons (MSNs) in the striatum and cortical neurons in the cortex. It is caused by an expansion of CAG repeats in the exon-1 of IT-15 gene, which results in a mutated polyglutamine …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
… we explored pathogenesis with an emphasis on neuropathogenesis in several murine models. Herein, we explored the pathogenesis of three CVV strains from lineage I, lineage II, and reassortant viruses in immune-competent and immune-compromised murine models, as well as different inoculation …
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Modelling Huntington’s Disease Using Direct Cell Reprogramming
… in HD. The expression of genes involved in HD neuropathogenesis were examined and found to be similar in normal and HD. An investigation of brain-derived neurotrophic factor and associated receptor signalling in the presentation of an HD phenotype suggested a role for altered receptor …
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Hiv And Antiretrovirals In The Central Nervous System: Molecular Mechanisms Of Cognitive Impairment
… that may each contribute distinctly to HAND neuropathogenesis. First, we showed that β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which may play a role in the onset and progression of Alzheimer’s Disease, was both increased in HIV+ patient brains and required for HIV-associated …
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Characterization of Flavivirus-Infected Neurons
… will contribute to the knowledge of TBFV neuropathogenesis by defining the inflammatory response in human neuronal cells and indicating structural changes that could contribute to long-term sequelae.
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THE ROAD LESS TAKEN: CHARACTERIZING THE TRIGEMINAL NERVE ROUTE OF NEUROINVASION BY RESPIRATORY SARS-COV-2
… the potential mechanisms of coronavirus-induced neuropathogenesis and underscores the importance of further research into the neurological impacts of COVID-19.
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The involvement of the kynurenine pathway in the pathogenesis of multiple sclerosis
… to characterize the involvement of the KP in the neuropathogenesis and the progression of MS. Using serum and cerebrospinal fluid (CSF) samples from MS patients, EAE mice, the most common animal model for MS and primary culture of human oligodendrocytes, we have studied the involvement of the KP …
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Examination of Abnormal Dolichol Metabolism in Infantile Batten Disease Caused by Palmitoyl Protein Thioesterase-1 (PPT1) Deficiency
… fatty acid and dolichol metabolism in the neuropathogenesis of NCL has been explored by analyzing LLOs from mouse models of Batten disease and other non-NCL lysosomal storage diseases (LSDs), and by characterizing a unique fusion protein consisting of PPT1 and a dolichol metabolizing enzyme …
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Upregulation of Reactive Oxygen Species During The Retrovirus Life Cycle and Their Roles In A Mutant of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration
… Given the complexity of the retrovirus-mediated neuropathogenesis, studies using small animal models are extremely valuable. Our laboratory has used a mutant moloney murine leukemia retrovirus, <em>ts</em>1-mediated neurodegneration. We hypothesize that astrocytes play an important role in …
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Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates
… may mediate viral replication and contribute to neuropathogenesis. In early HIV infection virus phenotypes that use CCR5 (R5) predominate whereas the acquisition of CXCR4 use (X4 or R5X4) may occur during disease progression. In addition, R5 virus may develop altered CCR5 use in late stage …
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Structural brain connectivity of HIV-positive children: a graph network analysis study
… Graph theory analyses have been applied to HIV neuropathogenesis previously, these have demonstrated significant disruptions to brain connectivity in older HIV+ adults on treatment. However, no previous studies have investigated the same topological organization or structural connectivity of …
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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1
… which we applied to investigate the course of neuropathogenesis in Neu1 KO mice, a faithful model of sialidosis. These mice develop a severe brain pathology sharing many hallmarks with Alzheimer’s disease (AD), including dystrophic neurites, progressive amyloidosis and neuroinflammation, …