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Showing 1 to 20 of 92 for “"neuropathic pain"”.
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Medicinal cannabis for neuropathic pain
Neuropathic pain is caused by a dysfunction of the nervous system. It differs from normal pain sensations as it is no longer protective and can be present in the absence of a stimulus. It affects eight percent of the population worldwide and has several causes. Diabetes is the most prevalent cause, …
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Genetic factors associated with neuropathic pain
<b>Background and Aim</b>: Neuropathic pain (NP) is a common chronic pain state, affecting approximately 7-10% of the general population. NP is multifactorial, with evidence of both genetic and environmental factors contributing to its development. Although the genetic contribution to NP …
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Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
In human, the neuropathic pain evoked by nerve injury includes severe mechanical allodynia and hyperalgesia in the region where the nerve innervates. The mechanism of the development of neuropathic pain was not yet well known and the solution for it was not also elucidated. The ligation of L5 …
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Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
Neuropathic pain is caused by altered nerve function that often presents as allodynia, which is the painful perception of typically non-noxious stimuli. Neuropathic pain is commonly treated with GABA analogues, steroids, or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
Neuropathic pain caused by peripheral nerve damage results in ectopic neuronal excitability, primary sensory neuron degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. …
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Single and Combined Effects of Cannabinoids on Neuropathic Pain and Cognition
… Europe for the treatment of conditions such as neuropathic pain, and has been fast tracked by the USFDA for late stage clinical trials for a host of disorders, ranging from epilepsy to irritable bowel disease. Additionally, increasing preclinical evidence demonstrates that treatment with …
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Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy.
… have potential utility in the treatment of pain as diagnostics and for quantification of drug efficacy and safety. A qualified biomarker will capture overlapping disease mechanisms and will be responsive to treatment. The necessity for these strict requirements renders it difficult to …
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A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
Voltage-gated sodium channels (Navs) are responsible for the upstroke of action potentials in electrically excitable cells. Transmission of nociceptive information from the body periphery to the central nervous system is mediated by specific isoforms of Navs present in dorsal root ganglion (DRG) …
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Investigating the Cell-specific Mechanisms That Drive Sex Differences During Neuropathic Pain Development
Chronic pain patients often suffer from a decline in quality of life due to a lack of efficacious long- term therapeutics. Moreover, the prevalence of chronic pain conditions is on the rise, with an average increase of nearly 10 percent in patients per decade. This, coupled with the devastating …
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Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain
… research, post-spinal cord injury (SCI) chronic neuropathic pain remains refractory to treatment and drastically impairs quality of life for SCI victims beyond paralysis. Although inflammation and free radicals contribute to neuropathic pain in SCI, the mechanism is not completely clear. We have …
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Functional Magnetic Resonance Imaging of Peripheral Neuropathic Pain in the Spinal Cord and Brainstem
… studies investigating the neural signature of pain in humans have focused on the brain, and those studies concerned with more caudal areas (such as the spinal cord (SC) or brainstem) have used only experimental models of pain. The objectives of this study were 1) to determine the neural …
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Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
… of diabetes. Diabetic polyneuropathy, a painful complication of diabetes, remains untreatable, emphasizing a critical need for improved therapeutic strategies. Recent evidence suggests that exercise may facilitate recovery of peripheral nerve function in diabetes. However, the mechanism …
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Chronic Pain after Non-traumatic, Non-compressive Myelopathy: Characteristics and Predictors for Neuropathic pain
Introduction: Chronic pain is one of the most common and serious consequences of myelopathy. The aim of this study was to survey chronic pain experience in a neurology out-patient clinic and to determine potential predictors for neuropathic pain after non-traumatic, non-compressive(NTNC) …
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A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… a spinal cord injury (SCI) often develop chronic neuropathic pain (CNP). Unfortunately, the clinically approved, current standard of treatment, gabapentin, only provides temporary pain relief. This treatment can cause numerous adverse side effects that negatively affect the daily lives of SCI …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… sexual and bladder function, and chronic neuropathic pain. A rat model of spinal cord injury was used to study the mechanisms of chronic neuropathic pain. Chronically up-regulated reactive oxygen species (ROS) generated in neurons as a result of spinal cord injury contribute to the chronic …
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TWO TYPES OF ROS ARE DIFFERENTIALLY INVOLVED IN SPINAL SYNAPTIC PLASTICITY AND MECHANICAL HYPERSENSITIVITY IN NEUROPATHIC PAIN
… is believed to underlie the chronic nature of neuropathic pain. It has been shown that pain-relaying synapses in the dorsal horn express two forms of long term changes in excitability––long term potentiation (LTP) and long term depression (LTD)––which contribute towards increased pain signaling …
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
<p>Postsurgical and neuropathic pain are each clinically common, and often associated with ongoing pain. Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors. Preclinical studies using rodent neuropathic models have concentrated on allodynia driven by OA generated in …
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Novel Bifunctional Ligands For Neuropathic Pain: Design and Synthesis of Overlapping Pharmacophores of Opioid and Melanocortin Ligands
… changes in the central nervous system, such as neuropathic pain. There is growing evidence that drugs behave differently in pathological states than in normal states, thus preventing their effectiveness in pathological disease states. Therefore, a new paradigm for drug design is needed. In …
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Circulating Autoantibodies In Human Traumatic Spinal Cord Injury Subjects and Their Relationship to The Development of Neuropathic Pain
… causing considerable morbidity and mortality. Neuropathic pain (NP) ensues in 40-70% of SCI. An autoimmune response resulting from disruption of the blood-spinal cord-barrier may be a contributor to NP. However, the relationship between autoantibodies and NP after SCI in humans has not been …
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