Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 126 for “"neuropathic"”.
-
Medicinal cannabis for neuropathic pain
Neuropathic pain is caused by a dysfunction of the nervous system. It differs from normal pain sensations as it is no longer protective and can be present in the absence of a stimulus. It affects eight percent of the population worldwide and has several causes. Diabetes is the most prevalent cause, …
-
Genetic factors associated with neuropathic pain
<b>Background and Aim</b>: Neuropathic pain (NP) is a common chronic pain state, affecting approximately 7-10% of the general population. NP is multifactorial, with evidence of both genetic and environmental factors contributing to its development. Although the genetic contribution to NP …
-
Foot Deformity and Bone Strength in Charcot Neuropathic Osteoarthropathy
<p>Charcot neuropathic osteoarthropathy: CN) is characterized by progressive degradation of bones and joints in a denervated, inflamed foot and ankle. Diabetes mellitus: DM) and peripheral neuropathy: PN) are the most common precursors of CN, which can lead to pedal fracture, subluxation, and …
-
Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
In human, the neuropathic pain evoked by nerve injury includes severe mechanical allodynia and hyperalgesia in the region where the nerve innervates. The mechanism of the development of neuropathic pain was not yet well known and the solution for it was not also elucidated. The ligation of L5 …
-
Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
Neuropathic pain is caused by altered nerve function that often presents as allodynia, which is the painful perception of typically non-noxious stimuli. Neuropathic pain is commonly treated with GABA analogues, steroids, or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more …
-
Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
Neuropathic pain caused by peripheral nerve damage results in ectopic neuronal excitability, primary sensory neuron degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. …
-
Liquid crystal thermography in neuropathic assessment of the diabetic foot.
… in the patient with diabetes mellitus. Routine neuropathic evaluation includes assessment of sensory loss in the plantar skin of the foot using both the Semmes Weinstein monofilament and the biothesiometer. Progressive degeneration of sensory nerve pathways is thought to affect thermoreceptors …
-
Single and Combined Effects of Cannabinoids on Neuropathic Pain and Cognition
… Europe for the treatment of conditions such as neuropathic pain, and has been fast tracked by the USFDA for late stage clinical trials for a host of disorders, ranging from epilepsy to irritable bowel disease. Additionally, increasing preclinical evidence demonstrates that treatment with …
-
Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy.
… and development. Current animal models of neuropathic pain are inadequate to develop biomarkers as they only cover ‘no pain’ and ‘high pain’: not the heterogeneity that exists between these extremes. Therefore, a novel rat model of graded neuropathic pain was developed by advancing the …
-
A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
Voltage-gated sodium channels (Navs) are responsible for the upstroke of action potentials in electrically excitable cells. Transmission of nociceptive information from the body periphery to the central nervous system is mediated by specific isoforms of Navs present in dorsal root ganglion (DRG) …
-
Investigating the Cell-specific Mechanisms That Drive Sex Differences During Neuropathic Pain Development
… directed towards interventions during early neuropathic pain development make it difficult to assess how functional changes in cellular phenotypes following injury can be manipulated to prevent maladaptive pain plasticity from taking place. The goal of our research was to use an innovative …
-
Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain
… research, post-spinal cord injury (SCI) chronic neuropathic pain remains refractory to treatment and drastically impairs quality of life for SCI victims beyond paralysis. Although inflammation and free radicals contribute to neuropathic pain in SCI, the mechanism is not completely clear. We have …
-
The effect of an exercise intervention on peripheral sensorimotor function in neuropathic diabetics
… due to the risk of exacerbating associated neuropathic complications. Therefore the purpose of the current thesis was to investigate the effect of a low-impact balance and lower limb strength training intervention on the sensorimotor complications of peripheral diabetic neuropathy. Ten …
-
Functional Magnetic Resonance Imaging of Peripheral Neuropathic Pain in the Spinal Cord and Brainstem
… a patient population diagnosed with peripheral neuropathic pain. The SC and brainstem contain important synaptic points in several major pain pathways, and comparing the neural response between a control and patient population in these areas provides a more complete picture of healthy and …
-
Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
<p>Exercise is now established as an integral adjunct to the management of diabetes. Diabetic polyneuropathy, a painful complication of diabetes, remains untreatable, emphasizing a critical need for improved therapeutic strategies. Recent evidence suggests that exercise may facilitate recovery of …
-
Chronic Pain after Non-traumatic, Non-compressive Myelopathy: Characteristics and Predictors for Neuropathic pain
… clinic and to determine potential predictors for neuropathic pain after non-traumatic, non-compressive(NTNC) myelopathy. Methods: We analyzed54 patients with a history of NTNC myelopathy at the neurology out-patient clinic. All patients completed questionnaires on pain severity, descriptors and …
-
TARGETING NEUROINFLAMMATION TO RELIEVE FABRY DISEASE NEUROPATHIC PAIN:EFFICACY OF PROKINETICIN SYSTEM ANTAGONISM AND MICROGLIAL INHIBITION
La malattia di Fabry (Fabry Disease, FD) è un disordine genetico da accumulo lisosomiale causato da una deficienza parziale o totale dell’enzima α-galattosidasi A (α-Gal A), codificato dal gene GLA localizzato sul cromosoma X (Xq22). Questo deficit enzimatico porta all’accumulo di …
Page 1 of 7