Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3083 for “"neurons"”.
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Adaptation in multisensory neurons
… have revealed many response properties of DSC neurons, such as cross-modal enhancement (CME) and sub-additive/additive/super-additive operational modes. CME occurs when the response of a multisensory neuron to stimulation in one sensory modality is enhanced, often non-linearly, by temporally …
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Information Encoding by Individual Neurons and Groups of Neurons in the Primary Visual Cortex
… visual stimuli encoded into the responses of neurons in the cerebral cortex? In this thesis, I describe the analysis of data recorded simultaneously from groups of up to eight nearby neurons in the primary visual cortices of anesthetized macaque monkeys. The goal is to examine the degree to …
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Characterization of Flavivirus-Infected Neurons
… responses, as well as less apoptosis, while neurons infected with POWV exhibited aberrations forming in the dendrites. These anomalies were consistent with previous findings using tick-borne encephalitis virus (TBEV) infected murine primary neurons and the formation of laminal membrane …
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Imaging Chloride Homeostasis in Neurons
… simultaneous measurements in vivo in multiple neurons. Combining random mutagenesis screening, protein engineering and two-photon-imaging this thesis work led to the discovery of new chloride-sensitive GFP mutants and to the establishment of ratiometric imaging procedures for the quantitative …
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Degenerative mechanism in dopaminergic neurons
The degenerative mechanisms of dopaminergic cells in Parkinsona??s disease (PD) remained elusive even after many years of research. However, many have hypothesized that the cell deaths in PD are via apoptosis and in particularly, by the mitochondrial-mediated apoptotic pathway. As such, the purpose …
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Higher Brain Neurons Succumb to Acute Stroke-Like Insult While Lower Brain Neurons Strongly Resist
Pyramidal neurons (PyNs) in ‘higher’ brain are highly susceptible to acute stroke injury yet ‘lower’ brain regions better survive global ischemia, presumably because of better residual blood flow. Here we show that projection neurons in ‘lower’ brain regions of hypothalamus and brainstem …
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Age-Related Deficits in Electron Transport Chain Complexes in Rat Neurons and 3xTg-AD Mouse Neurons
In neurons, mitochondrial quantity and basal cellular respiration are maintained with age, but alterations in other key functions and quantities make these cells susceptible to the pathology of age-related neurodegenerative disease. We observed age-related decreases in cytochrome C, cardiolipin, …
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Spontaneously Regenerative Corticospinal Neurons in Mice
… of the ventral horn, including directly to motor neurons. Barcode-based Multiplexed Analysis of Projections by Sequencing (MAPseq) of the CST revealed that the neurons contributing these axons primarily comprise a class of bilaterally projecting CSNs and represent a more substantial population of …
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On Training Neurons with Bounded Compilations
… Empirically, we show that our approach can train neurons with higher accuracy and more compact OBDDs.</p>
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Lysosomes and Ribonucleoprotein Dynamics in Neurons
… deficits. Given the selective vulnerability of neurons to lysosomal dysfunction, a better understanding of the unique functions of lysosomes in neurons is necessary. To gain deeper insight into the biochemistry of neuronal lysosomes, we developed methods to engineer and culture human …
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Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
… two distinct populations of Kiss1 expressing neurons are predominant in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion: the arcuate nucleus (ARC) and the anteroventral periventricular nucleus (AVPV). The two populations play distinct …
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Angiotensin II signalling in sensory neurons
… the presence of receptors for Ang II on sensory neurons may point to additional roles in nociception in inflammatory disease. Work in this Thesis sought to examine the identity of sensory neurons with which Ang II interacts, the mechanisms underpinning these interactions, and the consequences on …
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Acoustic responses from primary vestibular neurons
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1993.
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Detection of SK2 Channels on Hippocampal Neurons
… precise spatial organization of SK channels in neurons has remained unknown. Such knowledge is critical as the subcellular distribution of SK channels is an important determinant of neuronal excitability. Currently, there are no techniques to image ion channel distribution quantitatively at the …
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Developmental And Signaling Mechanisms Of Touch Neurons
… However, under pathological conditions, these neurons can aberrantly activate noxious pain sensations instead. Here, I explore developmental mechanisms of LTMRs and their mature functions under pathological conditions. In Chapter 2, we examine the role of a specialized population of roof …
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Temporal Processing by Caenorhabditis elegans Sensory Neurons
… We show that C. elegans chemosensory neurons can operate in a highly deterministic and low-noise mode, and they act as reliable linear filters of their input. We then use dynamical systems analysis in combination with classical genetic perturbation to uncover cellular and circuit …
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Mass Spectrometric Characterization of Peptides in Neurons
The MALDI-based approach is inherently different from conventional methods, in that essentially all peptides present at significant concentrations are detected, not only those which are pre-selected or radioactively tagged. Furthermore, single cells, nerves, and vesicles are screened without the …
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